Biomedical subjects

B Faye

Publications and source records attributed to B Faye.

At least 37 records · Page 2Linked to original sources

PubMed2002

[Preparation of a syrup with Bakis roots (Tinospora bakis) and evaluation of its choleretic activity in rats].

The aim of this work was to prepare a pharmaceutical using the aqueous extract of bakis roots and to check if the choleretic activity of this latter was maintained in cholestatic rats. So, a sirup was prepared and tested. The obtained results had shown that the aqueous extract maintained its choleretic activity. Indeed, when it was used at a dose of about 7.5 mg/100 g of weight, the sirup induced a significant increase of bilary secretion in healthy rats and cholestatic rats, confirming the results observed with the aqueous extract. Therefore, futher investigations in order to improve the quality of the sirup can be considered before performing clinical trials.

Animals↗

PubMed2002

[Contribution to the study of the anti-inflammatory activity of Moringa oleifera (moringaceae)].

Moringa oleifera is a bush of African savannah, used in folk Medicine for the treatment of rheumatic and articulary pain. We have tested the anti-inflammatory action of an aqueous extract of root in rats with weight between 120 and 160 g. We administered per os either distilled water (control group), the aqueous root extract (750 mg/kg or 1000 mg/kg) or indomethacin (10 mg/kg) 30 min before an oedema was induced in the rat-paw by subcutaneous injection of carrageenin. The rat-paw volume was measured 1, 3 and 5 hours after injection of carrageenin. At a dose of 750 mg/kg the Moringa oleifera treatment significantly inhibited the development of oedema at 1, 3 and 5 hours (reduction by 53.5, 44.6 and 51.1% respectively). Increasing the dose of Moringa oleifera to 1000 mg/kg did not increase the inhibitory effect on oedema development at 1 and 3 hours, whereas this dose potentiated the oedema at 5 hours. Treatment with indomethacin significantly inhibited the development of oedema 1, 3 and 5 hours (49.1, 82.1 and 46.9% respectively). These findings indicate that an aqueous root extract of Moringa oleifera at 750 mg/kg reduces the carrageenin induced oedema to similar extent as the potent anti-inflammatory drug indomethacin. Moreover, these results provide further evidence that the roots of Moringa oleifera contain anti-inflammatory principle that may be useful in the treatment of the acute inflammatory conditions.

Animals↗

PubMed2001

The use of multilevel models to evaluate sources of variation in reproductive performance in dairy cattle in Reunion Island.

Sources of variation in measures of reproductive performance in dairy cattle were evaluated using data collected from 3207 lactations in 1570 cows in 50 herds from five geographic regions of Reunion Island (located off the east coast of Madagascar). Three continuously distributed reproductive parameters (intervals from calving-to-conception, calving-to-first-service and first-service-to-conception) were considered, along with one Binomial outcome (first-service-conception risk). Multilevel models which take into account the hierarchical nature of the data were used to fit all models. For the overall measure of calving-to-conception interval, 86% of the variation resided at the lactation level with only 7, 6 and 2% at the cow, herd and regional levels, respectively. The proportion of variance at the herd and cow levels were slightly higher for the calving-to-first-service interval (12 and 9%, respectively) - but for the other two parameters (first-service-conception risk and first-service-to-conception interval), >90% of the variation resided at the lactation level. For the three continuous dependent variables, comparison of results between models based on log-transformed data and Box-Cox-transformed data suggested that minor departures from the assumption of normality did not have a substantial effect on the variance estimates. For the Binomial dependent variable, five different estimation procedures (penalised quasi-likelihood, Markov-Chain Monte Carlo, parametric and non-parametric bootstrap estimates and maximum-likelihood) yielded substantially different results for the estimate of the cow-level variance.

Animals↗

PubMed2001

[Food habits and oral hygiene of students. Investigation of 150 students in university housing].

The objective of this study is to describe the food intake and the oral hygiene habits of 150 Senegalese students living in a university campus. According to Miller, we realised a four days survey. We noted an increase of sugar drinks; tea is the most consumed drink. The results showed also that the toothbrush as means of oral hygiene supplanted the traditional means such as "cure dents" or water rinse with finger.

Adolescent↗

PubMed2001

[Oral hygiene habits and dental caries among students. Investigation of 150 students in university housing in Dakar, Senegal].

The objective of this study is to describe the oral hygiene habits and the status of the teeth decay of 150 senegalese students living in a university campus. The results showed that the toothbrush as mean of oral hygiene supplanted the traditional means such as "cure dents" or water rinse with finger. Results showed also a high rate decay (60%) but the CAO index remained low (2.04%). We founded an improvement of dental decay status with an increasing daily number of tooth brushing: we noted a decreasing dental plaque deposition rate, a decreasing decay rate and a CAO index remaining low until adult age.

Adolescent↗

PubMed2001

[Outcome of endodontic retreatments at the Institute of Ondonto-Stomatology of Dakar (from 1986 to 1997].

The retrospective study on the endodontic retreatments done at the Odonto-Stomatology Institute of Dakar from 1986 to 1997 shows a small rate of 1.94% (unreached canalar root filling) for 4325 endodontic treatments. The endodontic retreatments concern almost women (54.76%), ageing between 20 to 30 years (45.24%); maxillary central incisors (21.43%) and first molars (21.43%). The clinical reason having conducted to a retreatment is prosthetic (46.4%) and symptomatic (38.10%); the immediate success rate of these retreatment stays favourable at 59.52%.

Adult↗

PubMed2001

[Endothelium-dependent relaxation of Wistar rat aorta in late pregnancy].

Some authors usually described an enhanced vascular reactivity to vasodilatoragents during pregancy. We would like toverifythis hypothesis with acetylcholin which is the vasodilator agent habitually used in animal experimentation. Young adult Wistar rats, pregnant and nonpregnant, were used. Rats received either a control diet, or this control diet supplemented with nitroargininin (0.063 % i.e. 30 mg/kg for7 days [treated group], from day 13th to day 20th for pregnants. Relaxation of rings thoracic aorta, with or without endothelium, in the presence of acetylcholin in cumulative was studied after contraction induced by depolarisation with KCl or after noradrenalin addition. The results show that relaxation in the presence of acetylcholin needs functional endothelial cells and that the nitric oxide plays a key role in this relaxation. So, there is no difference in vascular reactivity in late pregnant rats compared to nonpregnant rats. In addition, chronic inhibition of nitric oxide synthesis in pregnant rats do not modify pregnancy reactivity to nitric oxide because relaxation to S-nitroso-N acetyl penicillamin, which is a nitric oxide donor, is not different in control pregnant rats compared to treated pregnant rats. A judicious observation of work conditions with a particular attention with calcium concentration in organ bath solutions would certainly explain contradictory results obtained by different authors on vascular reactivity in vitro during gestation.

Acetylcholine↗

PubMed2000

[A clinical study of composite restorations in anterior teeth using the Ryge criteria. Apropos of 120 cases performed at the University Hospital Center in Dakar].

In this two years retrospective study the authors determined the rate of survival composite restorations and evaluated clinically the remaining restorations by the Public Health Service (P.H.S.) criteria of Ryge. These restorations were performed by students using Heliomolar composite with scotchbond 2 adhesive dentin system. Results have shown that after two years, 98 (81.67%) out of 120 restorations were present and 51.2% were still working. Clinical evaluation of the remaining restorations needed replacement mainly because of severe color mismatch. Anatomic form and marginal adaptation were well scored after two years (score Alpha or Bravo). This study has shown that composite material is a valuable and effective technology for conservative treatment of anterior teeth in Senegal to avoid tooth extractions and prosthetic. However the knowledge about the type of composite material used must be improved and the operative procedures should be more controlled.

Acrylic Resins↗

PubMed2000

[Pain in intracanal treatment. A clinical study apropos of 150 cases].

This study was conducted to determine the incidence of pain during and after root canal treatment. Complete debridement and root canal preparation was performed in first visit. The frequency of pain was recorded and evaluated in 150 patients receiving root canal treatment. Results has shown that incidence of pain was 6.66% root canal preparation in vital teeth and 21% in non-vital teeth (necrosis). Post-obturation pain occurred in 18.75% for vital teeth and 13.15% non-vital teeth (necrosis).

Chi-Square Distribution↗

PubMed2000

[Protein profile of Senegalese children presenting with nephrotic syndrome].

In Senegal, nephrotic syndrome usually occurs upon malnutrition that confers it its specificity and has brought us to establish the proteinic profile of Senegalese children suffering from it, in the aim to improve its treatment. Twenty children on the average of six years, hospitalized for nephrotic syndrome, were chosen. They were compared to 20 healthy children of the same age group, and 20 other children hospitalized for a non-renal inflammatory syndrome. For each subject were dosed total blood proteins and albumin. The protein electrophoresis has permitted to evaluate the alpha-1, alpha-2, beta and gamma globulins. We have observed predominance of boys with a 2.33 sex ratio. Our patients presenting a nephrotic syndrome were about six years old; no case has been noted before two years. Total proteins and albumin have decreased respectively to 52.10 g/l and 16 g/l. This diminishing is essentially linked to the massive urinary escape of plasmatic proteins and would explain partly the increase of lipids. The alpha-1 globulins were equally lowered but the alpha-2 globulins were increased by 40% of total proteins. Beta globulins have decreased, following the evolution of gamma globulins. In Senegal, The early age of nephrotic syndrome occurrence and the biological perturbations of the proteinic profile, recommend global and quick treatment considering food recovery and nutrition. The correction of these parameters being able to constitute in one hand an element of accessible and reliable supervision, and one the other hand the basis of complete treatment.

Adolescent↗

PubMed2000

[Antidiabetic activity of Zizyphus mauritiana Lam (Rhamnaceae)].

In traditonnal medicine, several plants were used in diabetes treatment. Among them, the aqueous extract from the leaves of Zizyphus mauritiana Lam (Rhamnaceae) was studied. The extract was administrated per os to Wistar rats made diabetics either temporarily by oral glucose tolerance test (first case) or definetely by subcutaneous injection of alloxan (second case). It was observed a striking decrease of the hyperglycemic arrow (p < 0.05) in the first case, with 300 mg/kg administrated 90 minutes before starting the test. In the second case, the results obtained with a dose of 300 mg/kg once or twice a day were identical as those with glibenclamide at 0.2 mg/kg per day. So, the antidiabetic activity of Zizyphus mauritiana Lam was experimentally born out but it has to be standardized for common use.

Alloxan↗

PubMed2000

[Delayed root canal therapy. Data on the frequency and complications].

This retrospective study of 118 teeth receiving root canal treatment was conducted to determine the frequence and complications of delayed root canal treatment. Teeth were categorised into prompt treatment group and delayed treatment group according to the length time of treatment; prompt treatment group was defined as a group where root canal treatment was achieved within a period of 4 months or less, and delayed treatments group, a group where period of treatment was greater than 4 months or where canals were never obturated. Two types of complications were studied: postobturation pain and fracture involving tooth extration. The results of this study have shown that 34.5% of treatments were delayed. In this group we found also a higher rate of fractures involving tooth extraction, but the difference was not significant. The results have also shown that disappearance of pain was the essential factors in the frequence of delayed treatment, but the dental chair breakdown had some responsability. As well as in the two groups, the first reason of extractions was fracture and not pain. These results emphasize the necessity of focusing the patient's motivation on the risk of losing the tooth.

Adolescent↗

PubMed1999

From 'ecopathology' to 'agroecosystem health'.

The 'epidemiologic revolution' of the 1960s arose in response to the inability of reductionist methods to provide practical solutions to the complex problems of health and production in livestock systems. In a farm, there are not only interactions between animal factors and herd husbandry factors such as feeding, housing, and microbiological environment, but also with a number of other 'non-animal' factors. For this reason, a 'global' or 'holistic' approach, aimed at explaining animal health status within the overall dynamic of a livestock production system, was developed in France under the title of 'ecopathology'. In ecopathology, the discipline of epidemiology is integrated into a systemic approach, including: the development of a preliminary conceptual model, sampling based on the structure of the livestock production system, the establishment of a field study by a multidisciplinary team, the organization and management of the animal health and production information, data analysis, the distribution of results to all participants and the development of a preventive medicine programme. The farm is also influenced by the social, economic and environmental setting to which it belongs. To account for this, a change of scale is necessary. The three elements of the livestock production system considered in ecopathology (farmer, herd and resources), at the level of the agroecosystem become a human community (farmers, consumers, decision-makers), an animal population, and the complex of human, social and economic conditions within the system. The concept of agroecosystem health is closely linked to the overall principle of improving the sustainability of the system. This and other measures of the health status of an agroecosystem can be assessed with methods developed by epidemiologists and other disciplines within a system's perspective. In this systems view, ecopathology provides a basis for assessing herd health whereas agroecosystem health develops the broader context into which ecopathology contributes.

Animal Diseases↗

PubMed1999

[Incidence of postoperative pain in single session root canal therapy (study in black senegalese apropos of 96 cases)].

This prospective study was conducted during a period of 30 days in 96 patients to determine the incidence of postobturation pain after single-visit root canal treatment in black Senegalese people. The canals of all teeth were hand-prepared and filled with zinc-oxide-eugenol paste by a Lentulo spiral paste filler. Patients were asked to categorize their pain according to the following criteria: No pain, Slight pain, Moderate pain and Severe pain. The data were analysed statically with chi-square test to determine the relationship, if any, between the pain experienced and sex, age, tooth type, apical level of root filling and number of treatment performed in the single-visit. Results show that eighteen patients experienced pain (18.75%); our results are ranging between 10% and 25% described in the literature. No significant correlation was found between postobturation pain and any other factor with the exception of the apical length of canal filling. Characteristics of postobturation pain after root canal treatment performed in single-visit in Senegalese people presents the same features as described in international papers, that is, pain appears early and analgesic therapy is effective.

Black People↗

PubMed1999

[Effect and mechanism of action of Tinospora bakis roots on biliary secretion using in vivo models].

The aim of this study is to determine the choleretic properties of lyophilized aqueous extract of Tinospora bakis roots. For thus, we have used healthy and cholestatic Wistar rats. After administration of the extract (4 mg/100 g of weight) biliary flow, biliary acids flow, biliary glutathione and glucose concentrations were measured by specific methods. Comparative results between treated rats and non treated rats show: For healthy rats: a significant increase of biliary flow, biliary acids flow in the group of treated rats versus non treated healthy rats. There were no significant difference in the glutathione and glucose concentrations. For cholestatic rats: we noted also significant increase of biliary flow, biliary acids flow and glutathione concentration in the treated rats group. These results suggest that Tinospora bakis has a choleretic effect in vivo which depends on biliary acids and/or glutathione concentration.

Animals↗

PubMed1998

Qualitative interaction between the observer and the observed in veterinary epidemiology.

The phenomenon of qualitative interaction between the research activity and the studied object exists in veterinary epidemiology, as in all observation-based disciplines. Observational studies carried out under farm conditions strongly involve the farmers and the farm's usual advisors in the data collection. This leads to various biological and sociological interactions between the observer and the observed that can modify the results of the study. Some methodological considerations are proposed in order to consider such qualitative interaction, from the designing of the study through to the interpretation of the results. Examples are presented to illustrate these ideas.

Animal Diseases↗

PubMed1998

Comparative study of copper and zinc metabolism in cattle and camel.

At an experimental farm, five camels and five cows were fed a similar basal diet for 6 mo. They received oral trace element supplementation for 3 mo (day 22-112). This supplementation included zinc, copper, selenium, manganese, iodine, and cobalt, and corresponded to twice the requirements generally recommended for cows. Plasma copper and zinc concentrations were significantly lower in the camels (61 micrograms/100 mL for copper and 38 micrograms/100 mL for zinc) than in the cows (111 and 83, respectively). The supplementation had no effect on plasma zinc concentration in the camels in spite of the low observed values in this species. Liver copper concentration at the beginning of the trial was lower in the camels (9 ppm) than in the cows (35 ppm), and stayed at lower levels during the entire supplementation period. There was no clear difference in fecal excretion of copper and zinc between the camels and the cows. The results suggested that trace element requirements are lower in camels than in cows and that camels regulate their plasma zinc concentration at a very low level (< 40 micrograms/100 mL).

Animals↗

PubMed1998

[Nitric oxide and isolated aortic contraction in a pregnant hypertension model by the inhibition of nitric oxide synthase in pregnant Wistar rats].

During gestation endothelium induces decreases in vascular responses to vasopressor agents but endothelium disease is followed by hypertension and enhanced vascular reactivity during preeclampsia. In a rat model of preeclampsia induced by NO synthase inhibition we study here isolated aortic contractions. From day 13 of gestation 2 groups of Wistar female rats were fed control (C) or nitro-arginine enriched diets (0.063%, i.e. 30 mg/kg/d) (treated) (T). On gestational day 20 systolic blood pressure (SBP, mmHg) is measured by tail cuff method and isolated thoracic ring aorta contractions are studied after depolarisation (KCl 60 mM) or norepinephrine (cumulative concentrations 10-9 M-10-5 M). After chronic NOS inhibition, hypertension develops: SBP is 154 +/- 2.17 in T and 116 +/- 3.75 in C, p < 0.01 and significant proteinuria (mg/d) appears: T, 63.4 +/- 21.6 versus C 3.08 +/- 0.48, p < 0.01. NO synthase inhibition in treated rats impairs the depressed contractile response obtained in the presence of endothelium in control rats but addition of L-arginine suppresses the effect of nitroarginine. Taking in account our results and those described in literature it appears that L-arginine treatment could ameliorate some pathologic pregnancies.

Animals↗