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Biomedical subjects

B F Cullen

Publications and source records attributed to B F Cullen.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Phagocytosis during general anesthesia in man.

Latex particle phagocytosis and reduction of nitroblue tetrazolium by leukocytes was inhibited during general anesthesia when 18 patients were anesthetized with either halothane and nitrous oxide or nitrous oxide-thiopentalphils per 100 cells contained latex and 15.7 less monocytes per 100 cells contained latex. This represents a decrease of 17 and 28 percent, respectively, from preanesthetic values. The number of resting and latex-stimulated neutrophils reducing nitrobule tetrazolium was decreased 1.3/100 and 5.3/100, respectively, and the number of resting and stimulated monocytes reducing nitroblue tetrazolium was decreased 2.6/100 and 10.7/100, respectively. Phagocytosis was inhibited similarly by the two forms of anesthesia. The inhibition of phagocytosis during anesthesia in relatively healthy patients is minimal and its clinical significance has yet to be determined.

Adjuvants, Anesthesia↗
PubMedDate not supplied

Anesthesia and the modification of response to infection in mice.

Anesthetic-induced immunosuppression, if clinically significant, could modify the natural course of infectious disease in vivo. To test this bypothesis, the localized response to IM Candida albicans and the mortality following fecal peritonitis were examined in anesthetized mice. Using these 2 models, halothane anesthesia was found not to modify the natural history of local sepsis but to significantly accentuate the mortality associated with the more severe infection. Possible explanations for these results include significant inhibition of reticuloendothelial function or plasma opsonization with relatively minor derangements of peripheral leukocyte capability.

Anesthesia, Inhalation↗