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Biomedical subjects

B Delcambre

Publications and source records attributed to B Delcambre.

At least 145 records · Page 8Linked to original sources
PubMed1982

[Results more than five years after osmic acid synoviorthesis of the rheumatoid knee].

Osmic acid synoviorthesis is an adjuvant form of local treatment for rheumatoid arthritis, the value of which has been demonstrated by a large number of studies over some 30 years. However, it is widely considered that the stability of the results of this type of synoviorthesis is less satisfactory than that obtained with isotope synoviorthesis and that osmic acid may damage the articular cartilage. The authors analyzed the results of a retrospective study of 90 rheumatoid knees treated by this method with a follow-up of more than 5 years (mean period 9 years). With such a follow-up, a satisfactory clinical result was seen in 44.5 p. cent of cases and radiological evaluation of the knees treated showed no worsening in initial signs in an identical percentage of cases. Best results were obtained in joints where there was little radiological damage and in cases of inflammatory or only moderately progressive arthritis, good results may also be hoped for in more severe or advanced cases. The good overall quality of the results obtained with a mean follow-up of 9 years would be in favour of the value of osmic acid synoviorthesis in the local treatment of rheumatoid arthritis.

Arthritis, Rheumatoid↗
PubMed1981

[Narrow lumbar canal syndrome. Symptomatology and evolutionary aspects].

The authors report a retrospective study of 77 patients with a narrow lumbar canal syndrome (NLC). They recall the semiology, and the clinical and radiological findings which permit one to make the diagnosis and discuss, with an average follow-up of two years, the results of medical treatment (42 cases) or surgical treatment (35 cases), and the management which should be adopted. Medical treatment appears to be indicated in the mild forms of NLC, 34% of patients in this series (functional symptoms reduced and normal neurological examination at rest and after effort) where one may observe 80% of good results. Similarly, medical treatment should be attempted in certain more severe symptomatic forms where are still obtained 26% of good results permitting one to await surgery, and then reserve surgical treatment for failures or relapses. Operation is however definitely indicated in the forms where there are marked neurological signs. Under these conditions, the results of surgery and medical treatment seem comparable and one may note on the whole 60% of good results.

Adult↗
PubMed1980

Failure to find C1q-binding material and anti-IgG antibodies in ankylosing spondylitis.

C1q-binding immune complexes (C1C), anti-IgG antibodies (anti-IgG Ab), and complement levels were investigated in the serum of 37 patients with ankylosing spondylitis (AS). In all these studies the mean levels observed in patients with AS were similar to those in 31 normal subjects. Moreover, no significative difference in either CIC or anti-IgG Ab levels was observed when the patients were classified in different clinical forms according to the localisation (peripheral and central) or to the gravity (mild and severe) of the AS. In a parallel study increased CIC and anti-IgG Ab levels were found in most of the 81 patients with seropositive or seronegative rheumatoid arthritis.

Antibodies, Anti-Idiotypic↗
PubMed1980

[Quantitative bone scintigraphy in the study of the sacroiliac joint in chronic inflammatory rheumatism].

Scintillation counting of the sacro-iliac bones using technetium pyrophosphate or diphosphate is a simple examination without danger. The uptake opposite each sacro-iliac bone is assessed by reference to that of the lumbar spine visible on the film. A study of a control group of 81 subjects permits one to determine the existence of variations in relation to age: the fixation is high in subjects under the age of 20 years and reduced in adults aged over 50 years. The 44 controls from 20 to 50 years, permit one to retain as reference value, the ratio 1.14 for the right sarco-iliac bone and 1.11 for the left sarco-iliac bone with a confidence interval of 0.13. There was noted a significantly high uptake during arthritis. Whether this was the axial form (40 cases) or the peripheral from (7 cases) and during Reiter's syndrome (15 cases). This hyperfixation was more frequent and more important when the sacro-iliac involvements (whether accompanied or not by radiological signs) were the cause of inflammatory pain. Increased uptake was also noted during other forms of chronic inflammatory rheumatism: rheumatoid arthritis (10 cases). Chronic inflammatory rheumatism (unclassifiable) 20 cases. It thus seems that one may retain in many cases the existence of sacro-iliac inflammatory changes without the latter being necessarily accompanied by clinical or radiological signs. The discovery of hyperfixation of the sacro-iliacs during chronic inflammatory rheumatism is further evidence in favour of the diagnosis of sacro-iliac arthritis but should be interpretated in the light of the general context.

Adolescent↗
PubMed1980

[Rheumatoid pleurisy. Apropos of 13 cases].

The extra-articular manifestations of RA are numerous and various. Among the latter, pleural involvement is not exceptional, but it is often overlooked for it may be latent. There have been few recent studies of this relationship. The authors report 13 cases of rheumatoid pleurisy collected over the last 7 years in rheumatology and chest units. They recall the frequency of pleurisy, their constitutional background, their clinical and radiological appearances and emphasise the diagnostic interest of a biochemical study of the pleural fluid: a fall in the glucose content and of complement levels are the main changes. A study of the complement system carried out in 11 patients showed a fall in total complement and of the C3 and C4 fractions in the pleural fluid, which shows local consumption of immunological origin. This factor and the clinical picture may be important in diagnosis. The course of these pleural effusions is favourable, complications are exceptional; their treatment is mainly the basic treatment of RA.

Adult↗
PubMed1979

[Corticosteroid osteoporosis (author's transl)].

Otseoporosis is a common and sometimes severe complication of all prolonged corticosteroid therapy. After reviewing the clinical, radiological, histological and biological features, the authors discuss the various physiopathogenic mechanisms: anti-anabolic effect of corticosteroids and decreased bone formation, and hyperparathyroidism secondary to the calcium deficiency induced by corticosteroids (fall in intestinal calcium absorption). Treatment should be preventive, based upon great car in the prescription of corticosteroids (absolute indication, minimal effective dose, alternate administration in certain cases) and upon improved calcium balance (calcium, vitamin D or its derivatives).

Adrenal Cortex Hormones↗
PubMed1979

[Absence of circulating immune complexes and of serum anti-IgG antibodies during ankylosing spondylarthritis].

The sera of 161 subjects hospitalized in a rheumatology department were tested for anti-IgG antibodies using a "PEG radioimmunoprecipitation assay" (RIPEGA), for circulating immune complexes using the liaison test with Clq 125I, and dosage of complement and its metabolites. No significant difference was found between the group of 37 ankylosing spondylitis and the group of 44 control subjects. The results were identical, whatever the form of the disease, be it peripheral or central, and evolutive or non evolutive. On the contrary, the study of the rheumatoid arthritis (47 seropositive and 34 seronegative) provided results in conformity to previous works. The different physiopathogenic origin of these two chronic inflammatory rheumatisms is discussed by the authors.

Antibodies, Anti-Idiotypic↗
PubMed1979

[Value of disk puncture in the diagnosis of infectious spondylodiskitis. Apropos of 48 punctures].

The authors report on their experience with discal puncture in the bacteriological diagnosis of 48 infectious spondylodiscites. This technique makes it possible to obtain a bacteriological certitude in 31 cases (65 per cent): Pott's disease (40 per cent) and 12 pyogene spondylodiscites (25 per cent), with 17 punctures remaining negative, including 5 technical failures, the needle not penetrating into the pinched disc. No incident was noted, demonstrating the harmless nature of this method. The authors insist upon the necessity of washing the disc in order to decrease the percentage of failures.

Bacterial Infections↗