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Biomedical subjects

B Cramer

Publications and source records attributed to B Cramer.

At least 55 records · Page 3Linked to original sources
PubMed1977

The effects of toxic and non-toxic serum phenytoin levels on carbohydrate tolerance and insulin levels.

The effect of toxic and non-toxic phenytoin levels on carobhydrate tolerance and insulin levels was studied in 18 patients with epilepsy and 17 control subjects. Toxic levels were defined as a serum level greater than 20 microgram/ml. Toxic levels occurred in 11 patients and nontoxic levels in seven patients. Blood glucose and insulin levels were measured at 30-min intervals for a period of 3 h following the ingestion of 50 g glucose. Blood glucose levels were measured by the ferricyanide method, and serum insulin levels by immunoassay of insulin with insulin antibody precipitate. Serum phenytoin levels were measured by gas liquid chromatography. The insulin profiles were the same for all three groups, but there was a significant delay in reaching peak glucose concentrations in patients with toxic levels of phenytoin. It was therefore confirmed that non-toxic levels of phenytoin do not affect carbohydrate tolerance or insulin levels when phenytoin is used in the routine treatement of epilepsy, and it has also been shown that toxic levels of phenytoin do not affect carbohydrate tolerance when the high levels are detected at an early stage.

Adolescent↗
PubMed1976

[Psychiatric consultation in pediatrics. Description and problems].

In this study of psychiatric consultations in a paediatric department, a description is given of the evolution and duration of treatment in the first 55 cases seen. Children ranged from age 1 month to 12 years. Two findings are of particular interest: most of the children were of a very young age (less than 3 years); most psychiatric treatments were of short duration. These results are due to the preventive orientation of our consultation and to the close collaboration between pediatricians and psychiatrists. The preventive approach allows for less heavy and costly measures than the standard long-term psychiatric treatment. This preventive approach is only possible if the diagnosis is established early. The pediatrician is in a better position than the psychiatrist to practice early detection, as in young children the psychopathology is often expressed through somatic channels. In cases where the pathology was detected at a later age, the treatment is usually more difficult.

Age Factors↗