Biomedical subjects
Publications and source records attributed to B Bruun.
Two cases of endocarditis caused by Cardiobacterium hominis are reported. There were no unusual clinical features of endocarditis in the patients except for the extensive valvular damage present at time of hospitalization. Properties with distinguish C. hominis from other fastidious, gram negative rods are oxidase and catalase reactions, indole production and carbohydrate fermentation pattern.
A case of pasteurella multocida meningitis in a 75-year old woman with chronic otitis media is reported. There were no unusual clinical features of meningitis in this case which distinguished it from meningitis due to other pyogenic bacteria. P. multocida is characterized by a distinctive biochemical pattern, and correct identification should not be difficult provided that the possibility of its occurrence in meningitis is kept in mind.
The results of blood cultures from a large number of Danish hospitals examined at Statens Seruminstitut in 1977 and 1978 have been analysed. Out of a total of 17, 518 cultures in 1977 and 17,820 in 1978, 1,626 from 830 patients and 1,544 from 832 patients yielded growth of pathogenic microorganisms. Cases of bacteremia with Enterobacteriaceae constituted approximately 50% of cases both in 1977 and 1978. Polymicrobial bacteremia occurred in 8.1% of bacteremic cases in 1977 and 7.5% of those in 1978. The microorganisms isolated and their frequencies were surprisingly similar to those found in 1965 and 1971 in an earlier investigation from this department. No change in antibiotic susceptibility was observed between 1977 and 1978. Retesting of 50 E. coli strains from 1965, 1971 and 1978 for susceptibility towards ampicillin, cephalotin, streptomycin and tetracycline indicated that no significant changes had occurred, contrary to the results of the earlier investigation. This fact stresses the importance of exploring the possibility of unnoticed methodological changes having occurred in the sensitivity testing systems before any conclusions can be drawn concerning apparent differences in antibiotic susceptibilities.
The genus Flavobacterium has undergone a number of changes during the last years resulting in a revised description of the genus in which restriction of Flavobacterium to certain low G + C content species is proposed. The purpose of the present study has been to see how a collection of 184 clinical and environmental strains of Flavobacterium-like organisms isolated in Denmark would fit into this latest revision. It was found that most of the different biochemical patterns represented gradually merged into each other, with certain patterns, however, occurring more frequently than others and corresponding to the already described taxa: F. meningosepticum, Flavobacterium group IIb, F. breve, F. odoratum, F. multivorum and F. spiritivorum. The lately proposed subdivision of the genus will need either revision or extension or both to cope satisfactorily with the situation revealed in this study.
116 cystic fibrosis patients were observed, by monthly examinations over an eight-month period, to investigate the importance of non-bacterial respiratory infections (NBI) in exacerbations of the respiratory disease. Sputum was examined for bacteria, and serum investigated for antibody response against virus, mycoplasma and chlamydia and for antibodies against Pseudomonas aeruginosa. During this period each patient had, on an average, 2.9 exacerbations of which 76% were associated with bacteria, most frequently P. aeruginosa (51%), and 20% with NBI, although bacteria were also present in most of these cases. No etiology was established in 18% of the exacerbations. The NBI were caused by respiratory syncytial virus (RSV) (9%), parainfluenza virus (5%), influenza virus (3.6%), adenovirus (2.4%), mycoplasma (0.6%) and chlamydia (0.6%). The incidence of exacerbations was higher in patients with chronic P. aeruginosa infections. RSV infections were more common in patients who developed chronic P. aeruginosa infection during the study period, and RSV infections were frequently associated with a rise of P. aeruginosa antibodies in patients who harboured these bacteria. The important role of NBI as mediators of onset of chronic P. aeruginosa infections in cystic fibrosis patients is suggested.
The Harlem regional stroke program has been a demonstration model designed to detect, treat, and follow up stroke and hypertension patients through collaboration with a municipal teaching hospital, community practitioners, local service organizations and a major medical school. Many aspects of the stroke program appear suitable for replication at the local or regional levels in varied settings. In particular, the program has demonstrated the need to link community outreach programs, stressing early detection and preventive-care education, with sustained treatment and follow-up programs. The stroke program has also suggested ways in which specialized programs can be incorporated into long-term comprehensive health planning and care facilities at local and regional levels.
Among 148 strains of Haemophilus influenzae isolated in 1975 from different localities in Denmark, none was found to be resistant to ampicillin. A majority of the strains belonged to biotypes I, II and III and the presence of a partial correlation between biotype and origin was confirmed.
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