Search PubMed⌕ Search

Biomedical subjects

B Brown

Publications and source records attributed to B Brown.

At least 325 records · Page 18Linked to original sources
PubMed1979

Effect of beta-blockers on exercise double product (systolic blood pressure x heart rate).

1 The effect of single oral doses of six beta-receptor antagonists on exercise-induced changes in double product (systolic blood pressure x heart rate) were studied in 25 human volunteers. 2 Three doses of propranolol, nadolol, oxprenolol, pindolol, timolol and atenolol were selected for study on the basis of in vivo beta-blocking potency. 3 Although all beta-blockers studied reduced the double product response to exercise, the pharmacodynamics of this effect differed markedly. 4 Pharmacodynamic half-lives, estimated for the drug tested, were 39 h for nadolol, atenolol 21 h, timolol 15 h, oxprenolol 13 h, propranolol 11 and pindolol 8 h. 5 These results suggest that the clinical choice of a beta-blocker with the least problems of compliance can be made on the basis of pharmacodynamics as well as pharmacological profile.

Adolescent↗
PubMed1978

Marijuana, alcohol, and combined drug effects on the time course of glare recovery.

The time course of light adaptation after intense light exposure is significantly delayed by alcohol, marijuana, and a combined dose of alcohol and marijuana. These effects were found in a double blind experiment, using 10 subjects. The experimental treatments were placebo, 0.75 ml/kg of 95% ethanol, 8 and 15 mg of delta9 tetrahydrocannabinol (THC). and 0.75 ml/kg of 95% ethanol together with 15 mg of THC. The marijuana-induced delay in recovery is doserelated. Both drugs produce delayed recovery for at least 2 h after drug ingestion. The combined alcohol and marijuana treatment produces little more than the effect produced by either drug alone, suggesting some antagonism between the drugs--a suggestion supported by a significantly lower blood alcohol level for the alcohol dose when combined with marijuana than when taken alone.

Adaptation, Ocular↗
PubMed1978

Families of young, hearing-impaired children: the impact of diagnosis.

In 1976--77 there were 15 families with young hearing-impaired children, living in Kingston or within a radius of 50 miles, who participated in a study, funded by the Atkinson Charitable Foundation, to evaluate the impact which the diagnosis of deafness made upon them and their families. The sample was too small for sophisticated statistical analysis, but certain indications are provided by the research. The age at which the children were diagnosed was remarkably late and physicians and other involved professionals were felt to be uncomfortable in facing the parents whose children had hearing losses. Parents willingly admitted their need for more guidance at the time of diagnosis but had, in many cases, become somewhat complacent in their responses to their children and their needs. A strong source of support at the preschool stage was felt to be the home-visiting teacher service provided by the Ministry of Education. A need for more in-home guidance was felt by most parents when their children reached school age. Similarly, a need was expressed for a locally based correspondence course.

Attitude↗