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Biomedical subjects

B Bloch

Publications and source records attributed to B Bloch.

At least 235 records · Page 13Linked to original sources
PubMed1980

Econazole nitrate in the treatment of candidal vaginitis.

Econazole nitrate (Ecostatin; Squib) in two dosage schedules, 150 mg per day for 3 days and 50 mg per day for 14 days, was found to be extremely effective, with cure rates of 84,9% and 92,4% respectively. As judged by symptomatic and clinical relief, recurrence rates and cure rates according to results of culture, there was no statistically significant difference between the two regimens. On the basis of the results of this trial and because of the advantages it offers, the shorter course can confidently be recommended as the initial treatment in candidal infections.

Adult↗
PubMed1980

Cryosurgery in cervical intra-epithelial neoplasia.

A study undertaken to assess the reliability and effectiveness of cryosurgery in cervical intra-epithelial neoplasia is described. During 1 5-year period a total of 416 patients were so treated and the records were studied retrospectively. This study demonstrated that 34% of patients were lost to follow-up, and that 24% of those followed up had residual disease of the cervix. It was therefore concluded that this form of treatment was inadequate for the hospital population concerned. An additional prospective study was undertaken, as a result of which cryosurgery is recommended only if adequate long-term follow-up is ensured, if skilled colposcopic evaluation is available throughout, and if the disease is limited to mild or moderate dysplasia in younger patients.

Adolescent↗
PubMed1979

The effect of cyclical administration of levonorgestrel and ethinyloestradiol on blood pressure, body mass, blood glucose and serum triglycerides.

The effects of two differing dosage schedules of ethinyloestradiol and levonorgestrel, taken cyclically as oral contraceptives, on blood pressure, body mass, blood glucose and serum triglycerides were measured. After 12 months there were no significant changes in systolic and diastolic blood pressure or blood glucose levels. There was a small but statistically significant increase in body mass after 1 year in the group taking levonorgestrel 15 microgram and ethinyloestradiol 30 microgram (P < 0,02), but not in the other group, although the mass in this group was significantly increased after 3 months of therapy. There was a statistically significant increase in serum triglycerides in the group taking levonorgestrel 50 microgram with ethinyloestradiol 50 microgram for 11 days, followed by levonorgestrel 125 microgram for 11 days, followed by levonorgestrel 125 microgram with ethinyloestradiol 50 microgram for 10 days. This effect appears to be dose-related and progressive with continued therapy; the significance of these results is discussed.

Adolescent↗
PubMed1979

Ovarian dysgerminoma with embryonal carcinoma: A case report.

The association of an ovarian dysgerminoma with embryonal carcinoma in a 19-year-old woman is described. This is a highly malignant combination resulting in very rapid tumour growth and dissemination. A case report is presented and the aetiology, malignant potential and subsequent management of this most unusual tumour are discussed.

Adult↗
PubMed1979

Infundibular neurons of the human hypothalamus simultaneously reactive with antisera against endorphins, ACTH, MSH and beta-LPH.

In man, discrete neurons of the infundibular (arcuate) nucleus contain compounds that can be stained with anti-endorphin (alpha and beta), anti-ACTH, anti-MSH (alpha and beta) and anti-beta-LPH immune sera (I.S.). In the fetus, certain neurons stain with anti-beta-endorphin or anti((17--39)ACTH starting from the 11th week of fetal life. At the ultrastructural level, these neurons contain elementary granules that are immunoreactive with anti-beta-endorphin. In the adult, neurons immunoreactive with anti-beta-endorphin are found in the infundibular nucleus. Their axonal fibers terminate around blood vessels in the neurovascular zone and in the pituitary stalk, or establish contacts with non-immunoreactive perikarya of the infundibular nucleus. These neurons can be stained with anti(17--39)ACTH and anti-beta-endorphin I.S. The most reactive are also stained moderately with anti-alpha-MSH, anti-beta-MSH, anti-beta-LPH, anti-alpha-endorphin, or anti(1--24)ACTH I.S. These results indicate that, in man, compound(s) identical with or immunologically related to endorphins, beta-LPH, ACTH and MSH are secreted by certain hypothalamic neurons. These agents probably originate from a common precursor molecula similar to the so-called pro-opiocortin.

Adrenocorticotropic Hormone↗
PubMed1979

Sterilization.

Explore the source record for details and available documents.

Birth Rate↗
PubMed1979

Pituitary tumours in pregnancy. A case report.

A case report is presented of acromegaly occurring during pregnancy. The problems arising in association with pituitary tumours in pregnancy are discussed and current views on management are outlined.

Acromegaly↗
PubMed1979

Neurons of the rat hypothalamus reactive with antisera against endorphins, ACTH, MSH and beta-LPH.

In rat brains intraventricularly injected with colchicine, the same discrete neurons of the arcuate and ventromedial nuclei can be stained with antisera against alpha- and beta-endorphins, (1-24)ACTH, (17-39)ACTH, alpha- and beta-MSH, and beta-LPH, as demonstrated by comparative studies in consecutive serial sections. These neurons are strongly reactive with anti-(17-39)ACTH, anti-beta-endorphin, anti-alpha-MSH and anti-beta-MSH, and more faintly stained with anti-alpha-endorphin, anti-beta-LPH and anti-(1-24)ACTH. Exceptionally, neurons reactive with anti-(17-39)ACTH and anti-beta-endorphin are poorly stained or completely negative with anti-alpha-MSH and anti-beta-MSH. Immunoreactive fibers end in the lateral median eminence and in the arcuate nucleus proper, or form ascending pathways along the third ventricle. Comparative studies with other antisera or with the Falck and Hillarp technique show that these neurons differ from the elements producing LH-RH, somatostatin, neurophysin, oxytocin, vasopressin and dopamine. These results suggest that the same neurons of the rat hypothalamus synthesize several neuropeptides identical with or immunologically related to endorphins, ACTH, alpha-MSH and beta-LPH, probably arising from a common precursor molecule similar to that found in the corticotropic cells of the pituitary. These neuropeptides of a common cellular and molecular origin might be involved in basic processes of the central nervous system as neurotramsmitters or neuromodulators.

Adrenocorticotropic Hormone↗
PubMed1979

Comparative study of the neuronal populations containing beta-endorphin, corticotropin and dopamine in the arcuate nucleus of the rat hypothalamus.

Neurons simultaneously immunoreactive with anti-beta-endorphin and anti-(17-39) corticotropin (anti(17-39) ACTH) have been detected in the arcuate and ventromedial nuclei of the hypothalamus of colchicine-treated rats. These neurons are different from those fluorescent with the Falck and Hillarp technique. These results show that in the arcuate nucleus, immunoreactive ACTH and beta-endorphine are stored in the same neurons which are different from dopamine-containing neurons.

Adrenocorticotropic Hormone↗
PubMed1979

[Immunocytologic analysis, in rat hypothalamus, of neurons producing peptides related to endorphin, ACTH, MSH and beta-LPH. Comparison with other peptidergic and monoaminergic neurons].

In rat hypothalamus intraventricularly injected with colchicine, the same neurons of the ventral region are stained with I.S. against alpha and beta-endorphin, (1-24) and (17-39) ACTH, alpha and beta-MSH, and beta-LPH. They are distinct from those producing LH-RH, somatostatin, neurophysin, and dopamine. These results suggest that the same neurons elaborate peptides identical with or immunologically related to endorphins, ACTH, alpha-MSH and beta-LPH, probably issued from a common precursor.

Adrenocorticotropic Hormone↗
PubMed1979

[Twin pregnancy following bromocriptine in an acromegalic patient staying sterile after removal of a pituitary adenoma. Immunocytochemical study of the tumor (author's transl)].

A pituitary adenoma was removed from a young woman who had acromegaly with galactorrhea-amenorrhea. Postoperatively, the dysmorphic acromegalic syndrome and galactorrhea decreased but amenorrhea, elevated serum GH and PRL concentrations remained. After Bromocriptine administration (5 mg daily) GH and PRL levels became normal, vaginal bleeding ensued within 3 months and a twin pregnancy was induced. An immunocytochemical study of the pituitary adenoma revealed the presence of two well defined, distinct cell types, each secreting one hormone with large preponderance of GH cells.

Acromegaly↗
PubMed1979

The ulcus-syndrome in cod (Gadus morhua). III. A preliminary virological report.

A bullet shaped virus presumably belonging to the Rhabdoviridae was isolated from a pool of 7 cods (Gadus morhua) with the ulcus-syndrome. This virus measured 55 x 175 nm. The virus caused CPE in PS (pike sarcoma) cells, but not in a number of other cell lines. From the same pool another virus was isolated in EPC (epithelia carp) cells. This virus was an icosahedron of 145 nm and most likely to be placed in the family Iridoviridae. Electronmicroscopic examination of papules from another 13 cods with the ulcus-syndrome failed to reveal any virus. Attempts to isolate virus from 33 individual cases of the ulcus-syndrome were successful in one single case only. The two viruses have not consistently been isolated from cods with the ulcus symdrome, but on the other hand they have never been isolated from cods without the ulcus-syndrome.

Animals↗