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Biomedical subjects

B Berman

Publications and source records attributed to B Berman.

149 records · Page 9Linked to original sources
PubMedDate not supplied

Interdisciplinary support of the gynecologic cancer patient.

The gynecologic cancer patient has unique needs and problems that require a specialized approach not available through traditional and established hospital services. Discussed here are the innovations made at one urban hospital to meet this patient's needs. Central to the program is an interdisciplinary committee that routinely reviews and plans health care services for the individual.

Female↗
PubMedDate not supplied

Treatment of Herpes simplex virus infections with topical antiviral agents.

Clinical studies of topical therapy against Herpes simplex virus (HSV) infections have been reviewed. Idoxuridine (IDU) 15% in dimethyl sulfoxide (DMSO), interferons, and penciclovir result in significant clinical benefit against this virus. IDU reduced pain duration and decreased time to loss of crust in a study of 301 patients. Alpha-interferon has shown synergism with other anti-HSV drugs such as caffeine, trifluorothymidine (TFT), DMSO, and nonoxynol-9. Finally, in a study of over 2,000 patients, application of penciclovir cream, both early and late in the course of HSV infection, decreased the duration of lesions, pain, and viral shedding. Acyclovir (ACV)-resistant strains of HSV are susceptible to (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine (HPMPC), and ascorbic acid shows promising effects against HSV. Using a vehicle that enhances skin penetration of a drug or possibly further exploring combination therapy may result in efficacious treatment of HSV. The possibility of topical vaccination or topical gene therapy may also prove beneficial in the future.

Administration, Topical↗