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B Beiguelman

Publications and source records attributed to B Beiguelman.

At least 37 records · Page 2Linked to original sources
PubMed1984

NADH-methemoglobin reductase and methemoglobinemia among leprosy patients.

The NADH-methemoglobin reductase activity as well as hemoglobin and methemoglobin levels were investigated in blood samples of 182 adult leprosy patients and 137 Brazilian army enlisted men. The level of sulfones in the blood samples of the leprosy patients, all of them ingesting a daily dose of 100 mg dapsone, was also investigated. The mean value of NADH-methemoglobin reductase activity exhibited by the leprosy patients did not differ from that observed among the healthy individuals. However, the variance of the former group was significantly higher than that observed among the healthy subjects. As a consequence, the proportion of individuals showing a partial deficiency of NADH-methemoglobin reductase was significantly higher among the leprosy patients (22.5%) than among the healthy individuals (2.9%). The activity of this enzyme among the leprosy patients was negatively correlated to the hemoglobin level and slightly positively correlated to age. The concentration of methemoglobin among the leprosy patients was slightly but significantly higher as compared to the healthy individuals. The increase of the methemoglobin level among the leprosy patients was influenced by the amount of sulfones in the blood. However, no case in which dapsone was ingested in a daily dose of 100 mg presented the signs or symptoms of toxic methemoglobinemia.

Adult↗
PubMed1983

[Thalassemia and Hansen's disease].

The beta-thalassemia trait was investigated among 165 Brazilians who were unmixed Italian descendants (80 Virchowian patients and 85 normal controls, composed of universitary students). The frequency of the beta-thalassemia trait was 6.25% among the Virchowian patients and 5.88% in the control group. In spite of the similar geographical distribution of both hanseniasis and the gene for beta-thalassemia in Asia, the present data does not support the hypothesis that hanseniasis might have contributed to maintain high prevalence of this allele by selection favouring beta-thalassemia trait.

Female↗
PubMed1974

Factors influencing the level of dapsone in blood.

The level of dapsone in the blood 4 and 6 h after the ingestion of the 7th daily dose of 100 mg of the drug was investigated in 36 adult males with leprosy who had normal renal function and were free of diarrhoea and emesis. The bimodal distribution of the dapsone levels at 6 h was shown by multiple regression analysis to be due to a negative correlation between this trait and the haematocrit value. Among the patients with high dapsone blood levels, 81.8% presented haematocrit values under 36%, whereas only 20% of those with low levels showed low haematocrit values. Partial regression coefficients, calculated for the dapsone level on the age, weight of the patient, estimated number of years since the onset of leprosy, number of years under sulfone treatment, and blood levels of haemoglobin, albumin, and globulins, did not show statistical significance.

Adult↗
PubMed1967

Leprosy and genetics. A review of past research with remarks concerning future investigations.

The few geneticists who are interested in leprosy have been working in this field only since 1962, and have made little progress in solving the problems presented by susceptibility to this disease.This paper reviews the research that has been conducted, with particular reference to the search for associations between leprosy and certain genetic markers. In each area, the advantages and limitations of different techniques are described, and attention is drawn to sources of bias that may invalidate many of the results that have been published. Of particular interest is the discussion of a new technique for evaluating resistance to-leprosy. The proposed technique is based upon the in vitro transformation of blood monocytes into macrophages, and the observation of their behaviour against Mycobacterium leprae.

Humans↗
PubMedDate not supplied

Genetic epidemiology of the Mitsuda reaction in leprosy.

This study comprised 544 nuclear families with 2,925 individuals tested for the Mitsuda reaction, from the Campinas region in Brazil. Segregation analyses suggest the segregation of a major gene (chi 2(1) = 0.07 - 0.07 = 0, p = 1), by failing to reject the hypothesis of Mendelian transmission and by rejecting the hypothesis of nontransmission of a major gene (chi 2(3) = 0.07 - 0.0 = 0.07, p > 0.99; chi 2(2) = 198.28 - 0.0 = 198.28, p < 0.0001).

Genetic Diseases, Inborn↗