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Biomedical subjects

B Azadeh

Publications and source records attributed to B Azadeh.

At least 19 recordsLinked to original sources
PubMed1996

Basal cell carcinoma in Qatar.

BACKGROUND: There is an increasing incidence of basal cell carcinoma (BCC) and skin cancer in general among various countries, where the sun is implicated as an important causative factor. METHODS: Results of clinical and histopathologic examination and the incidence rate of BCCs were recorded over a period of 5 years at Hamad Medical Corporation, Doha, Qatar. RESULTS: Basal cell carcinoma is the commonest skin cancer in Qatar. The average annual incidence per 100,000 residents of working manpower, standardized to the 1986 census, is 9.9 for both sexes and at all ages. Expatriates formed the highest proportion and of these, Europeans were predominant. The tumor was more frequent in men, on sun-exposed areas, was mostly of the nodular and infiltrative type, and occurred in the 3rd, 4th, and 5th decades. As a whole, persons with relatively heavily pigmented skin constituted 66.7% of the patients. CONCLUSIONS: Intense sunlight exposure during outdoor work and leisure activities in Qatar puts residents at increased risk for nonmelanoma skin cancer, even in persons with relatively pigmented skin.

Adult↗
PubMed1994

Glomus tympanicum chemodectoma: unusual radiological findings.

A 64-year-old Qatari female, with a one-year history of right otorrhoea and deafness, had a reddish-white mass projecting into the right ear canal, through the tympanic membrane, that proved histopathologically to be a paraganglioma. Computerized tomography (CT) of the temporal bones showed extensive destruction of the right mastoid bone, the posterior ear canal wall, and the sinus plate, with total disruption of the ossicles, simulating a malignant tumour, which is unusual for a middle ear paraganglioma.

Ear Neoplasms↗
PubMed1994

Rhinosporidiosis: immunohistochemical and electron microscopic studies.

Sixteen biopsies of rhinosporidiosis (15 nasal and one conjunctival) from 16 Southern Indian male immigrant workers showed mucosal lymphoplasmacellular infiltrates together with transepithelial elimination of nodular bodies and destruction of some late stage nodular bodies in histiocytic granulomata with central neutrophilic microabscesses. Early nodular bodies were immunohistochemically positive for alpha 1-AT, alpha 1-ACT, CEA, S100, fibronectin, amyloid-p-component, IgG, IgA, C1q and C3. Electron microscopy showed organized concentric lamellated bodies in early nodular bodies and not in end-stage nodular bodies which contained mostly amorphous electron dense materials. Structures formerly regarded as 'sporangia' and 'spores' are believed to be lysosomal bodies loaded with indigestible residues to be cleared via transepithelial elimination or segregated/destroyed by secondary immune/granulomatous responses.

Adult↗
PubMed1994

Localized Leishmania lymphadenitis. Immunohistochemical studies.

Tissues from 10 patients with localized leishmania lymphadenitis were stained by immunoperoxidase technique for leishmanian antigens, immunoglobulins (Ig), complement, components, alpha 1-antitrypsin, and fibrin and by routine and chloroacetate esterase techniques. Lymph nodes with leishmania lymphadenitis showed a granulomatous process with a varying degree of necrosis, leishmanian amastigotes, abundant plasma cells, and focal fibrosis. Leishmanian antigens stained by rabbit anti-Leishmania tropica antiserum was detected in lymph nodes with granulomatous lymphadenitis (eight cases examined) and in a skin lesion but not in a lymph node showing only nonspecific hyperplasia. Positive antigen staining was seen in leishmanian amastigotes, granulomata, and (in three cases) vascular smooth muscles. Dominant plasma cell classes were IgG and IgE. Macrophages and granulomata stained positively for IgG and IgE (but not for IgM or IgA), faintly for C3, and strongly for alpha 1-antitrypsin. Mast cells were few. IgG and IgE may be involved in a specific way in this condition; formation of immune complexes with leishmanian antigens leads to immunologically mediated lysis of the host macrophages. This finding is important for the understanding of the pathogenesis of leishmania lymphadenitis and for effective elimination of the parasites.

Animals↗
PubMed1994

Inflammatory pseudotumor of the spleen: a case report.

An inflammatory pseudotumour of the spleen mimicking a lymphoma clinically is reported. Immunohistochemical studies and the characteristic polymophous inflammatory and fibroblastic infiltrates confirm the lesion as benign.

Adult↗
PubMed1994

Spindle cell hemangioendothelioma in association with epithelioid hemangioendothelioma.

A forty-two-year-old man presented with a twelve-year history of a multilobular, firm, but nonulcerated tumor (6 by 4.5 cm) of the dorsum of the right foot. He had capillary telangiectasia of both ankles but no lymphedema. Results of tests for human immunodeficiency viruses I and II were nonreactive. The tumor showed a complex combination of features of spindle cell hemangioendothelioma, epithelioid hemangioendothelioma, and areas suggestive of a possible well-differentiated (lymph) angiosarcoma. The tumor was completely excised with minimal healthy margin. There was no evidence of local or distant lesion at one-year follow-up examination.

Adult↗
PubMed1993

Kikuchi's lymphadenitis in Qatar.

The clinicopathologic features of five cases of Kikuchi's lymphadenitis (histiocytic necrotizing lymphadenitis without granulocytic infiltration) occurring in Qatar are presented. There were three females and two males aged from 18 to 36 years with a mean of 29 years. Three were Indians and two were Qataris. Cervical lymph nodes were affected in all cases while one patient also had inguinal and femoral lymph node enlargement. Three patients achieved complete remission within three months. The differential diagnosis both clinically and histologically, included malignant lymphoma, toxoplasmosis, tuberculosis, leprosy, Yersinia and viral infections. To avoid errors in diagnosis, especially that of malignant lymphoma, attention must be paid to the location of the lesion, composition of the cellular infiltrate and the typical fibrinoid type of necrosis in the background.

Adolescent↗
PubMed1993

Esophageal cancer in Qatar.

There were 41 cases of esophageal cancer over a 7 years period in the State of Qatar. Qataris accounted for 30 (73.17%) of these cases while representing about 38% of the entire population. Also there is a slight preponderance of female cases especially among Qataris. Nutritional factors, dietary preferences, environmental factors, social status and habits as well as genetic factors may constitute important etiologic factors in the genesis of esophageal cancer in Qatar.

Adenocarcinoma↗
PubMed1991

Leprosy in Qatar.

Clinical and histopathologic features of 104 cases of leprosy diagnosed between 1982 and 1989 in the State of Qatar were studied. There were 88 male (84.6%) and 16 (15.4%) female patients aged 18 to 64 years. Eighty-four of the cases were diagnosed during the initial mandatory medical screening on arrival to Qatar. Almost all (103) were expatriates and only one 50-year-old woman was a Qatari. Indians formed the largest group (60.6%), followed by Bangladeshi (6.7%), Pakistani (5.8%), and others. The majority of cases were classified as lepromatous (43.3%) or tuberculoid (43.3%). Although Qatar is a relatively leprosy-free country, the influx of a large number of workers from developing countries seeking employment forms a potential public health hazard.

Adolescent↗
PubMed1991

Endometrial ossification.

A case of endometrial ossification in a 22-year-old woman is reported. Chronic endometritis following post-abortion evacuation was considered the basis for the osseous metaplasia in her endometrium. Besides being a reversible cause of infertility, endometrial ossification needs to be differentiated from mixed mesodermal tumours of the endometrium.

Abortion, Spontaneous↗
PubMed1990

Acyclovir-induced acute tubulo-interstitial nephritis.

Two patients with presumed herpes simplex encephalitis developed severe non-oliguric acute renal failure shortly after acyclovir infusions. Renal function returned to normal in less than 3 weeks after discontinuation of acyclovir. Renal biopsies done during the acute phase demonstrated interstitial oedema, eosinophils and cellular aggregates in both and granulomata in the second case suggesting acyclovir-induced hypersensitivity interstitial nephritis.

Acyclovir↗
PubMed1989

Genetic polymorphism of the B subunit of coagulation factor XIII in Libyans: occurrence of a fourth common allele, FXIIIB*6.

FXIIIB phenotypes were determined in neuraminidase-pretreated serum samples by using isoelectric focusing in ultrathin-layer polyacrylamide gels containing 1 M urea and subsequent immunoblotting. In a Libyan population sample from Tripoli, (n = 108) nine different phenotypes as products of four common alleles were recognized, with frequencies as follows: FXIIIB*1 = 0.6574, FXIIIB*2 = 0.2454, FXIIIB*3 = 0.0741 and FXIIIB*6 = 0.0231. It is suggested that FXIIIB*6 is the fourth common allele of the FXIIIB system in this population.

Alleles↗
PubMed1989

Linitis plastica-like carcinoma of the urinary bladder.

Two cases of signet-ring cell adenocarcinoma of the urinary bladder with a linitis plastica pattern of infiltration were studied. Mucin histochemistry indicated the presence of neutral and acid mucopolysaccharides and absence of sulphomucin. Immunocytochemistry of the tumour cells was positive for keratin and carcinoembryonic antigen, but negative for prostatic specific antigen and vimentin. The relevance of these observations to the differentiation and histogenesis of these tumours is discussed.

Adenocarcinoma, Mucinous↗
PubMed1989

Arterial fibrodysplasia: a regional cause of peripheral occlusive vascular disease.

The authors studied 17 cases of symptomatic arterial fibrodysplasia involving peripheral arteries without concomitant renovascular hypertension in Iranian males (age range: twenty-two to forty-five years). Affected arteries were most commonly the femoral, iliac, and popliteal, but in 2 cases the axillary and brachial arteries were also affected. Three cases were progressive. Differential diagnosis of arterial fibrodysplasia is discussed. It is concluded that this entity is the most common cause of peripheral occlusive vascular disease in younger Iranian males.

Adult↗