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Biomedical subjects

B Adelusi

Publications and source records attributed to B Adelusi.

45 records · Page 3Linked to original sources
PubMed1976

Herpes type-2 virus antigens in human cervical carcinoma.

Exfoliated cells from the cervices of 22 patients with histologically diagnosed squamous cell carcinoma of the cervix and from those of 24 control women were examined for herpes subtype 2 (HT-2) antigens by indirect immunofluorescence studies. This method demonstrated that cells from all the patients with carcinoma contained antigens related to HT-2 virus. In contrast, squamous cells from the cervices of 24 control women with no cervical disease and of 2 women with chronic cervicitis did not contain such HT-2 antigens. Although an etiologic role of HT-2 virus infection cannot yet be established, it is probable that such infection precedes neoplastic changes.

Adult↗
PubMed1975

Antibodies to herpesvirus type 2 in carcinoma of the cervix uteri in Ibadan, Nigeria.

Carcinoma of the cervix is by far the commonest gynecologic malignancy seen in Ibadan, Nigeria. In a study aimed at investigating the role of herpesvirus type 2 (HT-2) in its pathogenesis, antibodies to HT-2 were detected by immunofluorescence above a titer of 640 in 31 (70.5 percent) of 44 women with invasive carcinoma of the cervix as compared with five (11.1 percent) of 45 healthy women of the same age group. Analysis according to histologic types of growths showed that 31 (83.8 percent) of 37 cases of squamous-cell carcinoma had antibodies above a titer of 640, whereas none of the other types (one adenocarcinoma and six undifferentiated carcinoma of the cervix) had antibodies above this titer. It was concluded that the results of the present study support the hypothesis of an association between HT-2 and carcinoma of the cervix, most especially the squamous-cell type.

Antibodies, Neoplasm↗
PubMedDate not supplied

Correlation of smoking and coffee drinking with sperm progressive motility in infertile males.

The objective of the study was to assess the effect of some social characteristics on the forward progressive motion of sperms in males of infertile couples. The study was conducted in the Department of Obstetrics and Gynecology, King Kahlid University Hospital (KKUH), Riyadh, from September 1, 1994 to February 28, 1995. Semen specimens were obtained from 68 Saudi males of infertile couples, and 29 fertile males. Using computer-assisted semen analysis (CASA), sperm forward progressive motion was determined and graded on a scale of 1-4. The actuarial life table survival analysis method was used to investigate the sperm motility potentials across intervals 0-1, 1-2, 2-3, and 3-4 and the effect of smoking and coffee drinking was also determined on the sperm motility. Smoking was found to significantly improve sperm motility among the infertile group. Similarly, frequent coffee drinking was shown to enhance sperm motility. There is a need for further studies on the influence of smoking and coffee drinking, as well as the plethora of other influence of the daily life that may compound the detection of the subtle changes in semen quality.

Adult↗
PubMedDate not supplied

Demographic and fertility variables as determinants of spontaneous abortions in women with previous abortions.

The objective of the study was to examine the demographic and fertility factors that may predispose to spontaneous abortion in women with prior abortion. The study was conducted in King Khalid University Hospital, Riyadh, Saudi Arabia. It included a series of women who aborted their pregnancies over a period of months (January 1; 1992-December 31, 1992). Chi-square and Fisher's exact test were used to analyze the statistical relationship between abortion and various demographic and fertility, related to abortion. There was a direct statistically significant relationship between maternal age, level of education, parity and a history of previous abortion. In a multivariate logistic regression analysis, parity and history of previous abortion were found to be significant as determinants of recurrent abortion. Even though many of these risk factors are not preventable, counseling of the women about the value of education, early reproduction in the child-bearing age, and control of fertility would go a long way in reducing the incidence of fetal wastage in these women.

Abortion, Habitual↗
PubMedDate not supplied

Socio-demographic characteristics of the "unbooked mother".

In a study to investigate the characteristics of the "Unbooked mother", the medical records of 467 patients who presented for delivery with no prenatal care at the obstetric unit of the King Khalid University Hospital (KKUH), Riyadh, during the period 1991 to 1995 were evaluated. For controls, the records of 415 mothers who had pre-natal care in the Unit over the same period were also evaluated. Data pertaining to their socio-demographic characteristics, previous obstetric history, prevalence of pregnancy-related and familial diseases, gestation age at delivery and weights of the babies, were extracted and analysed using odds ratios and 95% confidence intervals (C.I.). The unbooked mother tended to be young (< or = 24 years), unskilled worker, or student. On the other hand, the booked ones tended to be primigravid, with pregnancy-related (PET) and familial diseases (hypertension and diabetes). However, the level of parity, gestation age and birth weights did not appear to significantly influence the tendency to be booked or unbooked. These findings highlight the group of women who should be targeted for health education counselling regarding the value of prenatal care. This way, one can avoid some of the catastrophes often said to be associated with deliveries in the unbooked mother.

Adult↗
PubMedDate not supplied

Clinical trial of cefoxitin (mefoxin) in parenteral therapy of septicemia (postabortal and postpartum) in Ibadan.

Cases of post-abortal sepsis are admitted every day into the University College Hospital (UCH), Ibadan, Nigeria. This derives from the high incidence of induced (illegal) abortions in this environment. The infections are usually caused by mixed bacterial flora, often resistant to the common antibiotics because of the indiscriminate use of these drugs. Any new drug that can be effective in the treatment of these resistant cases will be welcome. The efficacy of Cefoxitin in the treatment of twenty-five cases of postabortal sepsis was therefore compared with the efficiency of other antibiotics in the management of sixty other cases. Response to Cefoxitin was prompt. Temperatures settled within 96 h and no case of pelvic abscess resulted. It was concluded that Cefoxitin could well be a safe and effective alternative antibiotic to replace the common antibiotics to which many hospital organisms have developed resistance.

Adolescent↗
PubMedDate not supplied

Reproductive performance following active management of diabetic pregnancies at the University College Hospital, Ibadan, Nigeria.

This article presents a report of the first 5 years of an active approach to the management of diabetic pregnancies at the University College Hospital, Ibadan. During this period the incidence rate of diabetic pregnancy was 0.64 per 1000 deliveries per year. The mean birthweight (3.40 +/- 1.68 kg) of babies whose mothers had good diabetic control was lower than the mean birthweight (4.19 +/- 1.05 kg) of babies born to mothers with poorly-controlled diabetes. The difference was however not statistically significant (P less than 0.5). Whilst the overall perinatal mortality rate was 10.8%, there was a statistically significant difference in the perinatal mortality associated with poor control of diabetes (42.9%) when compared with good control (0.0%): P less than 0.02. The authors conclude that earlier booking in pregnancy, stricter control of diabetes by multiple insulin injections and improved cooperation of the patients will in future help to lower the perinatal mortality rate associated with diabetic pregnancy.

Adult↗