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Biomedical subjects

B Adelusi

Publications and source records attributed to B Adelusi.

At least 37 records · Page 2Linked to original sources
PubMed1982

Chlamydial genital infection in Ibadan, Nigeria. A seroepidemiological survey.

Sera from patients attending a sexually transmitted diseases (STD) clinic, a family planning clinic, and an antenatal clinic in Ibadan, Nigeria, as well as from male blood donors from the same area were tested for the presence of type specific antichlamydial antibodies using a modified micro-immunofluorescence test. Among men and women attending the STD clinic the exposure rates to Chlamydia trachomatis serotypes D to K (genital pathogens) were 18.7% and 26.7% respectively. Antibody titres suggesting active disease in these men and women were found in 11.8% and 22.7% respectively. The highest rate of exposure (35%) was among women attending the family planning clinic; of these women 25% had antibody suggesting active disease. Titres of IgG antibody in this study were similar to those found among men and women with chlamydial genital infections in the United Kingdom. Antibodies to serotypes D to K were also detected in 10.3% of women attending an antenatal clinic and in 9.9% of male blood donors. The prevalence of antibodies to C trachomatis serotypes A to C and lymphogranuloma venereum serotypes was low. These results suggest that the prevalence of chlamydial genital infections in Ibadan, both among STD patients and especially among those individuals not seeking treatment (family planning and antenatal clinic patients), is high. Since serious sequelae can follow chlamydial genital infections it is imperative to carry out further investigations in this area.

Antibodies, Bacterial↗
PubMed1982

Tumour-associated antigens in cervical cancer tissues and in the sera of Nigerian women with cervical cancer.

Soluble antigens and membrane-bound antigens were prepared from a pool of cervical cancer (CaCx) tissues. The soluble antigens were extracted by homogenization in Earle's balanced salt solution containing antibiotics, and the membrane-bound antigens were extracted by 3 M potassium chloride. For isolation of partially purified tumour-associated antigens (TAA), ammonium sulphate precipitation, ion exchange chromatography and gel filtration methods were employed. Hyperimmune rabbit sera prepared against partially purified CaCx tissue antigens, absorbed with pooled normal cervical (NCx) tissue antigen preparation and pooled normal human sera (NHuS), demonstrated three tumour-associated antigens (TAA-1, -2, and -3) in the soluble antigen preparations by the immunoprecipitin-in-gel reactions. Only one TAA (probably identical to TAA-3 of the soluble antigens) was obtained in the KCl extract. Similarly, the antisera detected circulating TAA (C-TAA) in the sera of twenty-seven of thirty-six (75%) patients with cervical cancer, one of eighteen (5.6%) women with benign gynaecological diseases, one of seventy-two (1.4%) pregnant women and none of thirty-six (0%) healthy controls. The test indicated high specificity, and the procedure shows great potential for immunodiagnosis of cervical cancer.

Animals↗
PubMed1980

Prognosis of pregnancy after threatened abortion.

Uterine bleeding in early pregnancy represents a definite threat to the developing embryo and constitutes a source of anxiety to both the patient and her clinician. In a prospective study of women with threatened abortion (TA) in the first and second trimesters of pregnancy in Ibadan, Nigeria, 48.8% of them aborted their pregnancies and there was no significant association between the various sociomedical factors considered and the outcome of pregnancy after TA. In like manner, routine admission of patients with TA into the hospital may not be essential for the preservation of the pregnancy. However, uterine bleeding as a symptom of abortion appears to be of greater risk if this occurs in the second trimester of pregnancy, and the predictive value of circulating progesterone levels in TA is significant. It is probable that uterine bleeding in the second trimester, especially when this is associated with low circulating levels of progesterone, may be pathognomonic of imminent abortion.

Abortion, Threatened↗
PubMed1980

The abdominal cocoon case report.

A girl of 17 is described who presented, six weeks after the end of her first pregnancy, with intermittent abdominal pain and an abdominal mass due to encasement of the terminal ileum in a 'cocoon' of fibrous tissue. The cocoon was excised and the patient did well. The aetiology and management of this condition are briefly discussed.

Adolescent↗
PubMed1980

Coital function after radiotherapy for carcinoma of the cervix uteri.

The interference of treatment with the sexual life of the patient is an important but relatively neglected aspect of the study of carcinoma of the cervix uteri. In a study of the coital function of patients who had radiotherapy for Stages I to III (FIGO Classification) carcinoma of the cervix in the University College Hospital (UCH), Ibadan, Nigeria, dyspareunia and the fear of recurrence of the malignancy accounted for a marked reduction in the frequency of intercourse after treatment of their disease. A significant finding was the disruption in marital relationships directly attributable to the illness. Steps to minimise these problems are discussed.

Adolescent↗
PubMed1978

Sero-epidemiology of type--2 (genital) herpes simplex virus infection in Ibadan.

Herpes Type 1 (HT-1) virus infection is prevalent in Ibadan, Nigeria. In a study to determine the prevalence of Herpes Type-2 (HT-2) virus infection in this environment by the complement fixation (CF) test, it was shown that antibodies to the virus were not found below the age of 14 years, after which there was a gradual rise from the 16-25-year age group to a peak in the 26-35-year age group. It was suggested that the pattern of distribution of HT-2 antibodies is compatible with the sexual habits of the different age groups, and is in support of the venereal mode of transmission of the virus.

Adult↗
PubMed1978

Histopathological studies of carcinoma of cervix uteri in Ibadan.

Carcinoma of the cervix is by far the commonest gynecologic malignancy in Ibadan. In a histopathologic study of the disease, 93.9% of all the cases were found to be of the squamous cell carcinoma variety while 6.1% were of the adenocarcinoma group. It was found that most patients with the well differentiated squamous cell carcinoma were above the age of 45 years in contrast to the undifferentiated carcinoma. Even though the difference was not statistically significant, it was speculated that cervical cancer manifesting itself before the age of 45 years may be more aggressive than that occurring in older women. Similarly, it was shown that increasing age, more frequent marriages and parity may augment the possibilities, at least in the negro population, of a woman developing adenocarcinoma of the cervix.

Adenocarcinoma↗
PubMed1977

Carcinoma of the cervix uteri in Ibadan: coital characteristics.

Carcinoma of the cervix uteri has been found to be the most common female malignancy in Ibadan, excluding the reticuloendothelial tumors. In a study to investigate associated etiological factors in this environment, it was demonstrated that certain coital characteristics of women with cervical cancer can be identified. These were a common denominator which could explain the frequency of the disease among some categories of patients who engage in early sexual practice, have intercourse frequently and with multiple partners, and have many pregnancies. Support was given to the view that a sexually transmitted factor might be important in the cause of carcinoma of the cervix.

Adolescent↗
PubMed1977

Sero-epidemiology of herpes type-2 virus and carcinoma of the cervix in Ibadan.

Various sero-epidemiologic studies, including the preliminary report from Ibadan, have established that most women with premalignant and malignant carcinoma of the cervix have serologic evidence of infection of herpes type-2 virus. Using immunofluorescence method, the earlier report in Ibadan was confirmed, whereby the prevalence of HT-2 virus antibodies was shown to be significantly associated with carcinoma of the cervix, especially the squamous cell type. However, there was no such association with the grade and stage of the disease.

Adult↗
PubMed1977

Haemoglobin genotype, ABO blood groups and carcinoma of the cervix.

Genetic factors have been suggested as having a possible aetiological role in the incidence of carcinoma of the cervix. With the high frequency of carcinoma of the cervix in Ibadan as well as the high incidence of sickle-cell trait, the haemoglobin genotypes and ABO blood groups were analysed in patients managed for carcinoma of the cervix uteri in the University College Hospital, Ibadan. No significant association was found between any haemoglobin genotype or blood group and carcinoma of the cervix. The protection afforded against malaria by the haemoglobin S trait does not seem to protect against the development of invasive carcinoma of the cervix.

ABO Blood-Group System↗
PubMed1976

Herpes type-2 viruses and gynaecological malignancies.

Numerous sero-epidemiologic studies have noted an association between Herpes Type 2 (HT-2) virus and carcinoma of the cervix. In a study to evaluate the role of this virus, if any, on the etiology of extra cervical pelvic malignancies in Ibadan, the prevalence of HT-2 virus antibodies was found not to be significantly different in patients with extra cervical pelvic malignancies (carcinoma of the vulva and malignant trophoblastic disease) and cases of chronic cervicitis when compared with healthy controls. It was therefore concluded that no association could be found between HT-2 virus and extra cervical pelvic malignancies.

Adult↗
PubMed1976

Polycystic ovaries. Presentation and response to wedge resection.

Polycystic ovarian disease has been recognised for quite a long time, although its presentations have varied from place to place. In a report of cases of polycystic ovaries seen in the University College Hospital, Ibadan, Nigeria, over a six-year period, it was shown that the syndrome of Stein-Leventhal identifies only a very small and probably artificial fraction of the much larger number of patients who actually have polycystic ovarian disease. It was further shown that the benefit derived from wedge resection in our cases was marked. Of the cases that were subsequently seen at follow-up, there was restoration of regular ovulatory menstrual flow in 83.3% and achievement of pregnancy in 33.3%. Hence, the observation that wedge resection is beneficial, and at times curative in polycystic ovarian disease seems to have a sound foundation.

Adult↗
PubMed1976

Preterm and other babies with low birthweights in Ibadan.

Earlier studies on the incidence of low birthweight babies were unanimous in the belief that this is a peculiarity of the developing countries, especially of the negro race. However, the more recent studies have shown that the differences in the incidence of low birthweights between the developed and developing countries might be due to other factors. In a study of birthweights in Ibadan, Nigeria, evidence was presented which showed that the level of socio-economic standards, rather than the peculiarity of geographical location or race, accounted for a high percentage of low birthweight babies. The various other factors associated with low birthweight babies in Ibadan were also highlighted.

Female↗
PubMed1976

Herpes type-2 virus antibody status in groups of patients with neoplasm in Ibadan.

Various studies have associated Herpes Type-2 (HT-2) virus with carcinoma of the cervix, especially the squamous cell type. In the present study, prevalence of HT-2 virus antibodies was found to be significantly higher in patients with squamous cell carcinoma of the cervix than in cases with squamous cell carcinoma of sites other than the cervix, and other pelvic and extrapelvic malignancies (P less than 0.001). It was concluded that no association could be found between Herpes Type-2 virus and malignancies of sites other than the cervix.

Antibodies, Viral↗