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Biomedical subjects

A Zimmermann

Publications and source records attributed to A Zimmermann.

At least 397 records · Page 22Linked to original sources
PubMed1979

Long-term effects of negative pions in female mice exposed to whole-body irradiation.

Long-term effects, especially the incidence of tumors, of whole-body exposure of female NMRI mice with either negative pions (peak or plateau region) or X rays have been studied in comparison to controls. Animals were irradiated at the age of 10 days after birth. The mice were then regularly examined for deaths and signs of severe disease, moribund animals being killed. A detailed histopathological work-up has been performed. The data show that the survival as defined by death or the time of autopsy is significantly lower in irradiated mice in comparison to controls, that there is no difference in reduction of survival between groups treated either with X rays or pions at peak region, but that a difference can be seen when comparing X rays with pions at plateau region. The incidence of ovarian tumors at any particular age is higher in mice treated with X rays or pions than in control groups, but significantly lower in animals exposed to plateau pions than in those treated with peak pions or X rays.

Animals↗
PubMed1979

[Angioimmunoblastic lymphadenopathy. 3 cases with polyclonal gammopathy].

Three patients with an atypical lymphoproliferative disorder disorder and polyclonal gammopathy have been reviewed retrospectively. The clinical and histological findings are compatible with the recently described entity of angioimmunoblastic lymphadenopathy. Two patients died within 6 months after the first symptoms of the disease. Circulating immuncomplexes were demonstrated in the serum of 2 patients. In one patient with a nearly fourfold increase of IgG, persistent hyponatremia was found.

Aged↗
PubMed1979

[BCG sepsis as a fatal complication of BCG vaccination].

Fatal septicemia with Bacillus Calmette-Guérin (BCG) following BCG vaccination is always caused by an underlying defect of immunologic mechanisms. At the Children's Hospital, University of Berne, two cases of BCG septicemia were recently observed. The clinical picture, course, and pathogenesis of the illness are discussed. The harmless complications of BCG vaccination are summarized, and a review of the literature on fatal disseminated BCG infection stresses the different type of immunologic mechanism defect and clinical course. Therapy with antituberculous drugs is ineffective. Other therapeutic measures are mentioned. Immunologic tests must be performed rapidly when fatal disseminated BCG infection is suspected, in order to organize genetic counselling as soon as possible. The question whether newborns should still be vaccinated in spite of the numerous complications is discussed and answered in the affirmative.

Antigen-Antibody Reactions↗
PubMed1979

Similarity between a kininogenase (kallikrein) from human large intestine and human urinary kallikrein.

A human colon kininogenase (kallikrein) was isolated by gel filtration on Sephacryl S-200 and affinity chromatography on Trasylolbound Sepharose, yielding a material with a specific activity of 1.3 U/mg (substrate: AcPheArgOEt). The molecular weight of the enzyme as estimated by gel filtration is approximately 70 000. After reduction with mercaptoethanol two bands were obtained in dodecyl sulfate eletrophoresis with molecular weights of 27 000 and 70 000. The bimolecular velocity constant for the inhibition by diisopropyl fluorophosphate was determined as 4 l x mol-1 x min-1. The preparation was characterized by immunological and enzymatic methods. Using the radioimmumoassay for human urinary kallikrein cross-reactivity and parallel binding curves were obtained. Kinin liberation from human high Mr-kininogen was totally inhibited by antibodies directed against human urinary kallikrein. Trasylol and diisopropyl fluorophosphate, but not by antibodies directed against human trypsin and plasma kallikrein. The effect on dog blood pressure was comparable to that obtained with human urinary kallikrein. The amino acid composition of human large intestine kallikrein is very similar to that of human urinary kallikrein.

Animals↗
PubMed1979

Preoperative radiotherapy and chemotherapy in hypervascular, high-grade supratentorial astrocytomas.

From a group of ten patients with hypervascular, high-grade, supratentorial astrocytomas, five were treated with pre-operative radiotherapy alone, and five with radiotherapy in combination with cytostatic drugs. The aim was to investigate the timing of intracranial operations in the multimodality therapy of brain tumors. The tumor size was diminished only in one case, but tumor vascularization was reduced in half of the cases by the pre-operative treatment. Survival was not improved. Surgical treatment still should be the first of the therapeutic measures. Pre-operative radiotherapy may be of value to reduce tumor vascularization in hypervascular, centrally localized tumors.

Adult↗
PubMed1979

[Familial nonendemic hemolytic uremic syndrome: nephrectomy and transplantation (author's transl)].

A case of familial hemolytic uremic syndrome (HUS) in a four"year-old boy is reported. In his family four adult members are affected with the same disease. In the present patient we decided to perform bilateral nephrectomy because of the inexorable evolution of the disease. The intervention was followed by a distinct improvement, both from the clinical and the laboratory point of view. The child has profited of a renal transplantation. Unfortunately, he died three weeks later because of a severe urological complication. The aim of this study was to examine the effect of bilateral nephrectomy and transplantation on the clinical, laboratory and pathologic anatomical findings, and to analyze the literature, in order to find out whether these measures should be applied in the treatment of familial HUS with severe evolution. The observations seem to confirm the hypothesis of a renal pathogenesis of primary non endemic familial HUS. Nephrectomy seems to stop the disease, and the risk of a recurrence of the HUS after transplantation may be small. The occurrence of the disease in five family members in three generations was interpreted in favour of a genetic predisposition with a dominant gene.

Child, Preschool↗
PubMed1979

[Differential diagnosis of postoperative fistulas of the urinary tract (author's transl)].

A case is demonstrated in which an indwelling intravenous catheter was pushed by mistake via V. subclavia and the right heart into the V. cava inf. There the catheter perforated the wall of the V. cava. The continued infusion induced a cystic retroperitoneal tumor. The puncture of this tumor was followed by a fistula that was misinterpreted as a fistula of the urinary tract.

Catheterization↗
PubMed1979

[Sclerosing lipogranuloma of male genitalia (author's transl)].

The term "sclerosing lipogranuloma" was coined in 1950 to name a peculiar granulomatous fatty tissue reaction that according to Smetana and Bernhard represents a "local reactive process which sometimes follows injury to subcutaneous fat tissue". Later other investigators have pointed out that injections of exogenous lipids probably cause this lesion. A case of sclerosing lipogranuloma in the scrotum is presented, in which paraffin hydrocarbon could be identified. As prior to the appearance of the lipogranuloma a paraffin containing ointment had been applied locally for three weeks a percutaneous resorption of paraffin as a possible etiology is discussed together with a review of the literature.

Administration, Topical↗
PubMed1979

[Papilloma of the prostate (author's transl)].

A report is presented of a male patient who had been operated on the prostate because of prostatic hyperplasia. The dissection of the resected specimen showed a nodular lesion ten millimeters in diameter. Histologically, this nodule presented the uncommon pattern of a papilloma of the prostate. The structure, histogenesis and probable benignity of this rare lesion are discussed.

Aged↗
PubMed1979

[Primary testicular tumors in childhood. Observations in 21 cases and a discussion of the necessity of metastasis prevention].

A retrospective analysis of 21 primary testicular tumors in childhood is presented. Histologic review revealed 4 differentiated teratomas, 14 yolk sac tumors, 1 rhabdomyosarcoma of testicular envelopes and 1 paratesticular sarcoma. One tumor could not be classified. Two patients with yolk sac tumor and the patient with the paratesticular sarcoma died. In 4 of the 14 patients with yolk sac tumor iliac and/or paraaortic lymphnodes were removed 8-15 days after hemicastration but no tumor cells were found. Of 3 children with yolk sac tumor who developed metastases, one had had prophylactic resection and another one prophylactic irradiation of the draining lymphnodes. 8 patients with yolk sac tumor received prophylactic chemotherapy, and none developed metastases. For patients with yolk sac tumor prophylactic chemotherapy is indicated, particularly if more than 2 months have elapsed between the first detection of a testicular mass and operation. In prepubertal boys with testicular teratoma no prophylactic therapy to prevent dissemination is necessary. Patients with yolk sac tumor have an age distribution comparable to that of patients with an embryonal tumor.

Age Factors↗
PubMed1979

Diabetic encephalopathy. Does it exist?

A case of a diabetic aged 65 years with an insidious progressive cerebral disorder with ataxia, tremor, general rigidity and mental deterioration is reported. Pathological examination revealed multiple small infarcts in the pons, the basal ganglia and medulla oblongata, corresponding to the lacunar state. The parenchymal lesions were associated with changes in the small arteries consistent with diabetic angiopathy. Since the patient was normotensive, the pathogenetic role of hemodynamic abnormalities in relation with diabetes is suggested.

Aged↗
PubMed1979

[Formation of chondroid tissue in the left ventricle and bundle of His in complex congenital cardiac abnormality (author's transl)].

The formation of chondroid tissue in the heart ventricles and in the region of the ventriculoatrial transition is regarded as a rare lesion of the human heart. We present the observation of a not well-known disorder of cardiac development connected with a cartilagineous transformation of endo- and myocardial tissue. Chondroid change was found in the innermost parts of the left ventricle in a heart with severe hypoplasia of left parts and aortic atresia. Cartilage-like tissue reached to the region of the bundle of His and to supraanular parts of the interatrial septum. The possible genesis of this change, that may be of clinical relevance, is discussed with regard to normal endo- and myocardial development.

Autopsy↗
PubMed1978

[Transitory early rejection of transplanted kidneys; course and prognosis].

Early acute rejection with oligo-anuria was observed in 9 cases among 103 cadaver kidney allografts transplanted between January 1969 and May 1977. According to our experience this type of rejection crisis occurs between the 6th and 9th day after transplantation. It is characterized by a typical clinical course. The beginning is acute with high fever and swelling of the graft, followed by oligo-anuria demanding treatment with hemodialysis. In all cases except one there was total restoration of graft function after an oligo-anuric period of 4--16 days. The late prognosis was good in 5 cases. The other 4 patients lost their grafts during the first 4 months after transplantation as a consequence of a second irreversible rejection reaction. The pathogenesis of this early acute and reversible failure of the transplant is discussed, together with the histologic findings in one case.

Adult↗
PubMed1978

[Indications and contraindications of liver biopsy].

In each individual case the indication for liver biopsy depends on assessment of the risks relative to the potential benefits of the procedure. Besides hepatological risk factors, hemostasis and overall health problems must be considered. The benefit of liver biopsy is dependent on recognition of the pathognomonic lesion within the tissue sample obtained. Size and distribution of the different histological features and the size of the biopsy cylinder are, therefore, important determinants for the success of the examination. Whether or not a histological diagnosis may be useful for optimal management of a patient can best be judged if the clinical question has been well defined before the biopsy is performed.

Biopsy↗
PubMed1978

A serological assay for the detection of cell surface receptors of nerve growth factor.

When single-cell suspensions prepared from embryonic day 8 (E8) chick sensory ganglia are incubated with nerve growth factor (NGF), anti-NGF antiserum, and complement, an NGF-dependent cytotoxic kill of 20 (+/- 3)% of the ganglia cells is observed. This percentage is increased by a factor of two when only the neuronal cells are tested. No kill is observed on the nonneuronal cell population representing 50% of the ganglia dissociate. When E8 sensory ganglia cells are cultured in the presence of NGF following cytotoxic kill, the large, phase-bright NGF-reponsive neurons are missing from the culture. These results indicate that the cells recognized in the cytotoxicity assay have to carry NGF-binding sites of type I, which is the one with the higher affinity of the two types of NGF-binding sites (I and II) present on sensory ganglia cells. This conclusion is further supported by the following data: a) half maximal cytotoxicity is reached already at a concentration of NGF which is below the KD of binding site I; b) a washing step which removes all NGF bound to type II receptors while leaving a high percentage of type I receptors occupied has no effect on the percentage of ganglia cells killed. Using the cytotoxicity assay the presence of high-affinity binding sites of type I can be demonstrated on sensory ganglia cells from E8 chick embryos but not from E4 embryos and not on liver and heart cells from E8 embryos. Further, type I receptor-bearing cells were detectable in the brain using this assay. At E8, NGF receptors could be detected on cells of the forebrain and the tectum but not on brain stem cells. Cytotoxic kill of forebrain cells was found to be especially high at E8 and E9, and decreased by E10.

Animals↗