Search PubMed⌕ Search

Biomedical subjects

A Yanai

Publications and source records attributed to A Yanai.

At least 73 records · Page 4Linked to original sources
PubMed1990

Identification and fine structure of proliferating hepatocytes in malignant and nonmalignant liver diseases by use of a monoclonal antibody against DNA polymerase alpha.

To analyze the process of liver regeneration and the initiation of hepatocellular carcinoma (HCC), we studied histochemically the morphologic features of proliferating parenchymal cells stained for DNA polymerase alpha (DPA), in 31 patients with various diseases, by use of a monoclonal antibody against DPA. In specimens from patients with acute viral hepatitis with confluent necrosis, most stained hepatocytes were small, with basophilic cytoplasm, and were located next to the necrotic areas. Under electron microscopy, stained granules were seen in the nucleus. Most stained hepatocytes had immature organelles. In specimens from patients with cirrhosis of the liver, the number of stained hepatocytes greatly differed in different pseudolobules. In specimens from patients with adenomatous hyperplasia, stained hepatocytes, mostly small and basophilic, were found diffusely; electron microscopy showed slightly indented nuclei with a few organelles and less condensed chromatin than normal. In specimens from patients with HCC, most stained cancer cells were small and basophilic; electron microscopy showed indented nuclei with a few organelles and less than normal condensed chromatin. Staining showed that during regeneration, immature hepatocytes reentered the cell cycle and repaired a large necrotic area. It was conceivable that in the initiation of HCC, some small hepatocytes with indented nuclei and less condensed chromatin might become HCC cells.

Antibodies, Monoclonal↗
PubMed1990

A contrivance for monitoring skin flaps with a Doppler flowmeter.

A monitoring procedure using a Doppler flowmeter for assessment of patency after microvascular surgery is reported. Thirty-two free flaps were monitored using this procedure. There were three problematic cases in which flap circulation was not evaluated by the Doppler flowmeter. One involved the existence of another artery beneath the pedicle. The second was one of distal necrosis of the flap caused by impairment of peripheral blood circulation, in spite of patency of the pedicle. The third case involved venous occlusion of the pedicle, that was clinically detected by evaluating flap color, and the flap was salvaged. Checking beneath the pedicle prior to anastomosis was instituted after the first case cited, and there has not been a similar complication. The procedure has been proved to be useful in flap monitoring.

Humans↗
PubMed1989

The influence of congestion and ischemia on survival of an experimental vascular pedicle island flap.

We investigated the relationship between the survival rate of experimental rat pedicle island flaps and mild vascular insufficiency, using a flap designed to induce constant distant necrosis. To eliminate individual variation, the vasculature of each flap was evaluated by injecting dye prior to ligating either or both of the pedicle vessels. Seventy-five male Wistar rats divided into four groups were used. Six of the rats died, so 69 rats were evaluated. Statistically, the dye distance of each group was the same. In the control group of 29 rats, survival length was directly proportional to dye distance. Although the mean values of the survival length minus the dye distance of each flap (delta S.L.) in the venous inadequacy group were not different from those of the control group, there was significant difference between the mean values of the arterial insufficiency and the venous inadequacy plus arterial insufficiency groups and those of the control group. In the pedicle island flap, mild venous inadequacy was less responsible for necrosis when the arterial inflow was sufficient. However, when the arterial inflow was impaired, even mild venous inadequacy affected flap survival.

Animals↗
PubMed1988

Our method of correcting cryptotia.

Our technique for the correction of cryptotia using both Z-plasty and the advancement flap is described. The main advantages are the simple design of the skin incision and the possibility of its application to cryptotia other than severe cartilage deformity and extreme lack of skin.

Child↗
PubMed1987

Treatment of recurrent subareolar abscess.

Recurrent subareolar abscess is an infrequent but troublesome disease of the breast among young women. Recent experience with 5 patients indicated that successful treatment of recurrent subareolar abscess requires excision of the diseased ducts and necrotic cavity, including the inverted section of the nipple. The operative procedure described herein allows us to radically manage recurrent subareolar abscess and at the same time leave a nipple with a good cosmetic appearance.

Abscess↗
PubMed1987

Problems encountered with the ratchet lock of the Mathieu needle holder.

It is necessary to modify the Mathieu needle holder by reversing the arms of the ratchet so that it will become better suited for right hand use than the present design. Such an improvement would decrease the possibility of the ratchet pinching gloves and causing tears during operative procedures.

Equipment Design↗
PubMed1986

Correction of the inverted nipple.

A simple procedure for correction of inverted nipples is described. The key to the method is the preparation of 2 deepithelized dermal flaps after supplementing the volume of tissue beneath the nipple, and preventing recurrence of the deformity with slings.

Breast↗
PubMed1986

Accordion flap.

The accordion flap is proposed as a means of covering a rhombic defect. A prominent feature of the method presented is in the preparation of a flap on one side of the skin defect, resulting in little dog ear.

Adult↗
PubMed1986

Direction of suture lines in Z-plasty scar revision.

Conventional methods of Z-plasty, a basic technique of plastic surgery, are incorrect since they are based on the assumption that the suture lines as designed prior to Z-plasty and those that actually result will coincide. For Z-plasty to be satisfactorily applied in scar revision, sufficient thought must be given to the actual directions in which the suture lines will lie in comparison with those envisioned.

Cicatrix↗
PubMed1986

Significance of deep body thermometer for assessing haemodynamics of free flaps.

A deep body thermometer was used in 13 cases of microvascular tissue transfer in order to assess the post-operative haemodynamics of the flaps. Nine of 10 cases involving free skin flaps demonstrated good blood flow by the temperature recovery curves in cooling and rewarming (CR) tests conducted immediately and 6 to 12 hours after operation but in the tenth, anastomotic problems were predicted by the tests. None of the three musculocutaneous flap cases demonstrated good blood flow patterns initially but two were good at 6 hours and did well. The third had a poor pattern at 6 hours and suffered partial necrosis. This study confirmed that it is possible to assess the state of circulation in a flap by the CR test after free flap transfer.

Adolescent↗
PubMed1986

The Z in Z-plasty must have a long trunk.

Erroneous thinking in regard to Z-plasty, which is a fundamental technique in plastic surgery, has been pointed out. In most cases of Z-plasty, the trunk of the Z should be designed longer than the two limbs.

Adolescent↗
PubMed1986

Reconstruction of the columella with bilateral nasolabial flaps.

Nasolabial flaps are beneficial in the reconstruction of total defects of the columella. Two nasolabial flaps were used in a one-stage reconstruction of the columella. Both flaps were simultaneously transposed as subcutaneous pedicle flaps and set up in a sandwich shape. We could reconstruct a well-shaped and balanced columella.

Humans↗