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Biomedical subjects

A Wessing

Publications and source records attributed to A Wessing.

At least 91 records · Page 5Linked to original sources

[Successful treatment of choroid hemangioma with secondary changes caused by Sturge-Weber syndrome].

A 12 year old patient was treated for Sturge-Weber syndrome with choroidal haemangioma and total exsudative retinal detachment. The diagnosis was supported by echography and thin-layer computed tomography. Because of the exsudative retinal detachment photocoagulation could not be performed. Treatment by percutaneous radiotherapy with Caesium 137 was performed. The retina was reattached by application of 30 Gray. A flat pigmented scar developed in the area of the haemangioma at the posterior pole of the eye. No side effects appeared. The follow-up time is 26 months.

Adolescent↗

[Treatment of malignant melanomas of the uvea with 106-ruthenium applicators. Report on the first 100 Essen cases].

The results of treatment of the first 100 patients with uveal melanomas treated with 106-Ruthenium applicators in Essen are presented. The mean follow-up period was 2 years; 80 of the patients presented with choroidal melanomas and 20 with melanomas of the ciliary body. Five of the 100 patients had metastatic disease originating from the primary uveal melanoma. Compared to 60-cobalt therapy, therapeutic results are similar in terms of tumor regression, but the incidence of complications was significantly lower. In 16 patients the eye with the tumor had to be removed, because of tumor growth (12), neovascular glaucoma (3), and vitreous hemorrhage (1). Visual acuity did not decrease in 20% of the cases treated. In the light of our results 106-Ruthenium therapy seems to be a reliable method of tumor treatment in tumors with a maximum prominence not exceeding 8 mm.

Aged↗

Nine cases of cavernous hemangioma of the retina.

The findings in nine patients with cavernous hemangioma of the retina confirmed the accepted characteristics of this malformation. Clusters of dark-red saccular aneurysms within the inner retinal layers were partly covered by a white epiretinal membrane. There was no clinical or angiographic evidence of exudation from the angioma and there was no growth during a median follow-up period of 6.3 years. The size of the aneurysms, the extent of the lesion, and the associated venous malformations varied greatly from case to case. Fluorescein angiographic findings during follow-up periods of as much as 16 years suggested progressive thrombosis and organization of the angioma.

Adolescent↗

Peripheral retinal telangiectasis in adults simulating a vascular tumor or melanoma.

In ten adult patients a localized peripheral retinal vascular lesion is described, which is characterized by retinal telangiectasia, formation of aneurysms, deposition of lipoidal material and exudative detachment. All patients were of middle or older age and men and women were affected equally. Small lesions had a definite association with the most peripheral vessels, whereas larger ones appeared more as a tumor-like mass causing exudative detachment with deposition of lipoidal material. Additional neovascularization was present in at least two of the ten patients. The lesion is of clinical importance because it is often the cause of loss of central vision and is often confused with a vascular tumor or a choroidal melanoma.

Adult↗

[Radiotherapy of the hemangioma of the choroid].

For the first time, a report is given on the percutaneous radiotherapy of hemangiomas of the choroid which could not be treated by photocoagulation. Diagnosis and control examinations of these tumors were performed by ophthalmoscopy, fluorescence angiography, and ultrasonography. Ten eyes (nine patients, three out of them with Sturge-Weber's disease) were treated between 1967 and 1982. A first group (five eyes, five patients) treated until 1974 received a target volume dose of 1,65 to 6,5 Gy combined with subsequent photocoagulation. All these eyes could be preserved. In addition, the second group (five eyes, four patients) treated since 1975 with unique radiotherapy showed better results with respect to visual acuity. The average follow-up period was four years (seven months up to nine years). Late effects were not observed. Even in case of advanced disease with retinal ablation and secondary glaucoma, an inactivation of the hemangioma of the choroid and a simultaneous regression of the secondary alterations could be achieved. According to our experiences, enucleations can be prevented by an irradiation with a target volume dose of 20 to 30 Gy.

Adolescent↗

Congenital retino-pigment epithelial malformation: a clinicopathological case report.

An unusual unilateral fundus lesion in a 16-year-old boy is described consisting of hyperpigmentation and presumed hypertrophy of the retinal pigment epithelium combined with malformation and thickening of the overlying sensory retina. Based on its clinical and histological characteristics, this lesion is considered to be a congenital retinal pigment epithelial malformation.

Adolescent↗

Congenital retino-pigment epithelial malformation, previously described as hamartoma.

Six patients with a congenital malformation of the retina and pigment epithelium had a slightly elevated greenish-blue or gray lesion in the macular area or fundus periphery composed of a flat, outer pigmented portion consisting of a layer of hyperpigmented, presumably hypertrophied retinal pigment epithelium and a prominent, unpigmented inner portion consisting of malformed thickened retina. Marked tortuosity of the retinal vessels was explained by an intraretinal disturbance of the retinal layering and the presence of preretinal membranes. Angiography revealed blockage of the background fluorescence caused by the abnormal retinal pigment epithelium and leakage from dilated, abnormal capillaries. Typically, the lesion was unilateral and was found in children or young adults who had monocular strabismus, reduced visual acuity, and often hyperopia. Most of the patients were males, and their cases were frequently misdiagnosed as tumors.

Adolescent↗