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Biomedical subjects

A Watanabe

Publications and source records attributed to A Watanabe.

1,247 records · Page 70Linked to original sources
PubMedDate not supplied

Intraperitoneal administration of cisplatin and etoposide during surgery for patients with gastric cancer.

Intraperitoneal chemotherapy has been attempted to treat peritoneal seeding in patients with gastric cancer. In this study, 13 patients with far advanced gastric cancer were given a complex chemotherapy regimen, cisplatin and etoposide, intraperitoneally during surgery. Cisplatin and etoposide was given 100 mg/body (58-90 mg/m2) and 200 mg/body (115-180 mg/m2), respectively, before closing the abdominal wall. There was one operative death who had an unresectable gastric cancer and died due to respiratory insufficiency, probably related to the drugs. There were no critical side effects due to the drugs among patients who underwent gastrectomy. Postoperative complications encountered were 2 cases of leukopenia, 2 of vomiting, 2 of renal impairment and 1 of liver dysfunction. These complications were transient and limited. The median survival duration was 7.0 months in this study. Thus, intraperitoneal cisplatin and etoposide should be examined for clinical use in larger scale trials.

Adult↗
PubMedDate not supplied

Intraperitoneal cisplatin during surgery for gastric cancer and peritoneal seeding.

Forty-five patients with gastric cancer having peritoneal seeding but no liver metastases received intraperitoneal cisplatin, 50 to 200 mg (89.4 mg on average), immediately after gastrectomy, while 37 controls were treated with intravenous mitomycin C on the day of their gastrectomy and daily oral tegafur (N1-(2'-tetrahydrofuryl)-5-fluorouracil) postoperatively. Side effects and postoperative complications after intraperitoneal cisplatin were limited. The postoperative survival rate was better in patients given cisplatin than in the controls (P < 0.05). A significant difference in survival was seen particularly in those with the undifferentiated type of gastric cancer or 'massive' peritoneal seeding. The succinate dehydrogenase inhibition test for chemosensitivity to drugs revealed that tissues obtained from the undifferentiated type of gastric cancer or foci of peritoneal seeding were more sensitive to cisplatin than to mitomycin C or adriamycin. These results demonstrate that intraperitoneal cisplatin after gastrectomy is safe and suitable for the treatment of patients with gastric cancer and peritoneal seeding.

Cisplatin↗
PubMedDate not supplied

Tentative diet for liver failure containing well-polished rice.

A liver-failure diet (low in protein) that contained rice polished to 50% to reduce the protein content of the diet was given to patients with uncompensated liver cirrhosis and compared with a standard liver-failure diet containing conventionally processed rice. The amount of boiled rice served in each meal could be increased by using well-polished rice and the use of supplementary sources of energy (powdered starch syrup, jelly, cookies, and candy sugar) was unnecessary. In the liver-failure diet containing well-polished rice, the methionine contents could be reduced and the Fischer ratio could be increased. The ingestion rate of the diet with well-polished rice was 80% and the diet was rated favorably in a questionnaire on palatability. Decreases in blood ammonia concentrations were observed in three patients given the liver-failure diet with well-polished rice for 2 wk by the crossover method.

Ammonia↗
PubMedDate not supplied

Elevated levels of serum and plasma metalloproteinases in patients with gastric cancer.

BACKGROUND: Levels of serum and plasma metalloproteinases, especially type IV collagenases are important factors related to metastasis and invasion in various human cancer. The clinical significance of serum matrix metalloproteinase 2 (MMP-2, 72 kDa type IV collagenase) and plasma matrix metalloproteinase 9 (MMP-9, 92 kDa type IV collagenase) was evaluated as possible tumor markers in gastric cancer. MATERIALS AND METHODS: The precursor form of MMP-2 (proMMP-2) in serum and the precursor form of MMP-9 (proMMP-9) in plasma were examined prior to surgery on 70 patients with gastric cancer, one-step sandwich immunoassay (EIA) was used and serum carcinoembryonic antigen (CEA) levels were also examined in the same patients. Normal sera and plasma samples obtained from healthy individuals without cancer were used as controls. RESULTS: ProMMP-2 levels in patients (mean +/- standard deviation) with gastric cancer (602 +/- 200 micrograms/l) were significantly higher than levels (542 +/- 80 micrograms/l) in sera from 70 healthy individuals (P < 0.02). Plasma proMMP-9 levels (119 +/- 232 micrograms/l) in patients with cancer were also significantly higher than those (37 +/- 13 micrograms/l) in plasma (P < 0.004). On the other hand, there was no significant correlation between CEA and proMMP-2 levels, and between CEA and proMMP-9 levels. Neither proMMP-2 levels nor proMMP-9 levels significantly related to clinicopathologic features. CONCLUSIONS: Serum proMMP-2 levels and plasma proMMP-9 levels may serve as tumor markers, independent from known factors and CEA.

Adenocarcinoma↗