Biomedical subjects

A Walsh

Publications and source records attributed to A Walsh.

At least 181 records · Page 10Linked to original sources

PubMed1978

Ocular penetration of 5-fluorocytosine.

Ocular penetration of 5-fluorocytosine (5FC) was studied in uninfected rabbits after subconjunctival and oral administration. With oral administration, 5FC achieved therapeutic levels in both the vitreous and aqueous humors. The use of a pharmacokinetic model permitted objective comparison of kinetic events within the eye chambers and the serum. The rates of entry and elimination in the vitreous were found to be slower than those in the aqueous, but the mean concentration over 24 hr was the same. The therapeutic levels achieved in the aqueous after subconjunctival administration were of shorter duration, and no detectable levels occurred in the vitreous. Oral administration is clearly therapeutically superior to subconjunctival administration in this model.

Administration, Oral↗

PubMed1977

Cost of ECG electrodes.

Explore the source record for details and available documents.

Costs and Cost Analysis↗

PubMed1977

Interstitial cystitis. Observations on diagnosis and on treatment with anti-inflammatory drugs, particularly benzydamine.

Interstitial cystitis is often missed on "routine" cystoscopy. If the disease is suspected, the bladder must be observed twice during complete filling. An anti-inflammatory drug, Benzydamine, has given mixed results but in view of its low toxicity it is worth trying in any patient with severe symptoms.

Anti-Inflammatory Agents↗

PubMed1976

Effect of lactation on lipolysis in rat adipose tissue.

The concentrations of nonesterified fatty acids and glycerol in rat parametrial adipose tissue increased at peak lactation. Adipose tissue from lactating rats showed higher rates of release of nonesterified fatty acids and glycerol when incubated in vitro than did tissue from nonlactating rats, but there was a substantial increase in the esterification of fatty acids during involution. These results support earlier evidence that fat reserves were mobilized during lactation.

Adipose Tissue↗

PubMed1976

Benzydamine: a new weapon in the treatment of interstitial cystitis.

Benzydamine hydrochloride was synthesized in 1966 and developed in Italy. It belongs to a chemical class that has not been used previously in the treatment of inflammatory conditions. Benzydamine is not related to steroids or other anti-inflammatory drugs, it is given by mouth and its toxicity is low. A pilot trial was done in 25 cases of interstitial cystitis and virtually complete relief of pain was noted in 18 cases.

Adult↗

PubMed1975

Composition of liver lipids of the rat during pregnancy and lactation.

Triglyceride concentrations in rat liver rose during late pregnancy, declined at peak lactation, and then rose again during involution. The percentage of oleate in the triglycerides rose at peak lactation, but that of linoleate fell. Although phospholipid concentrations were unchanged, the percentage of palmitate in this fraction rose, and those of stearate and arachidonate fell during pregnancy and lactation. These changes may be related to the changes in lipogenesis and fat mobilization that occur during pregnancy and lactation.

Animals↗

PubMed1975

The composition of the liver lipids of the ewe during pregnancy and lactation.

During late pregnancy and early lactation there were significant increases in the concentrations of triglycerides and cholesteryl esters in the liver lipids of the ewe. These changes were accompanied by higher concentrations of oleic acid and lower concentrations of stearic acid in both fractions, and may be related to an increased mobilisation of fatty acids from adipose tissue.

Animals↗

PubMed1974