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Biomedical subjects

A W Craft

Publications and source records attributed to A W Craft.

At least 199 records · Page 11Linked to original sources
PubMed1977

Child-resistant packaging and accidental child poisoning.

From Jan. 1, 1976, all children's aspirin and paracetamol preparations were required to be presented either in child-resistant containers or in dark-tinted unit packaging. In two areas hospital admissions of children under 5 years for accidental ingestion of aspirin were monitored from 1974 to 1976 to assess the effectiveness of this measure. There was a highly significant fall in admissions for accidental salicylate poisoning (129 in 1975 to 48 in 1976, P less than 0-001). Admissions fell throughout 1976 as old stocks were used up. Further analysis of cases in one area suggests that the fall in admissions from accidental salicylate poisoning was due to the packaging of one preparation of junior aspirin in child-resistant containers.

Accident Prevention↗
PubMed1977

Role of infection in the death of children with acute lymphoblastic leukaemia.

Twenty-four consecutive deaths from a total of 70 children receiving treatment for acute lymphoblastic leukaemia (ALL) have been reviewed. An attempt has been made to ascribe the cause of death to either infection, haemorrhage, the leukaemia itself, or a combination of these factors. No child was free of infection at death. Infection, with or without haemorrhage, was responsible for the deaths of all 15 children whose leukaemia had not relapsed. Although infection was present at death in all 9 children whose leukaemia had relapsed, the leukaemia process itself was also a major contributing factor. Viruses were associated with death in many of the children and may be emerging as important pathogens in children with ALL. Familiarity with a protocol may be an important factor in the prevention of fatal infections in such children. Centralization of treatment is necessary if this expertise is to be acquired.

Acute Disease↗
PubMed1977

Serial studies of numbers of circulating T and B lymphocytes in children with acute lymphoblastic leukaemia.

Serial studies of numbers of circulating T and B lymphocytes at monthly intervals in children with acute lymphoblastic leukaemia showed a marked fall in the number of B cells, relatively greater than that of T cells, early in the course of maintenance chemotherapy and immediately after a course of cranial irradiation. The fall in the number of B cell is not a consequence of long-term chemotherapy, and is possibly related to a specific event such as cranial irradiation.

Acute Disease↗
PubMed1977

Serum ferritin in juvenile chronic polyarthritis.

Six children with juvenile chronic polyarthritis were studied and their disease activity correlated with haematological values including serum ferritin. The latter is often raised above reference values, but even when within them appears to fluctuate significantly and correlates more closely with disease activity than any of the other parameters measured. We conclude that the serial measurement of serum ferritin may be a useful guide to the management of such children.

Adolescent↗
PubMed1974

Aspirin and analgesic nephropathy.

Renal function was studied in 17 patients with rheumatoid arthritis who had each consumed between 5 and 20 kg of aspirin. After an interval of two years 14 of these patients-seven of whom had consumed a further mean of 2 kg of aspirin-had their renal function retested. No relation was found between total dose, rate, or duration of ingestion and any aspect of renal function that was studied. All patients had plasma creatinine levels within the normal range, though slight depression in creatinine clearance was not uncommon.From this study and other published data we conclude that aspirin rarely if ever causes analgesic nephropathy when prescribed alone in doses appropriate to the treatment of rheumatoid arthritis.

Adult↗