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Biomedical subjects

A Vos

Publications and source records attributed to A Vos.

At least 145 records · Page 8Linked to original sources
PubMed1983

[Dyspnea caused by tracheal stricture following operative treatment of esophageal atresia].

This report describes eight children with esophageal atresia who developed 'dyspnea spells' during feeding. These spells were caused by a combination of tracheomalacia and tracheal compression. One patient in addition had a vascular ring. Common characteristics in these patients were: low birth weight, other congenital abnormalities and a short esophagus. The diagnosis was confirmed endoscopically. Operative therapy consisted of hemithymectomy and aortopexy. In six patients the symptoms disappeared completely, the two other children improved. The operation appears an effective means of dealing with severe dyspnea spells in children after correction of esophageal atresia.

Aorta, Thoracic↗
PubMed1983

[Complications following pyloromyotomy for hypertrophic pyloric stenosis].

In this series of 114 patients with infantile hypertrofic pyloric stenosis all were treated operatively, in eight cases perforations of the mucosa occurred, seven patients were referred to us after inadequate pyloromyotomy had been performed elsewhere. They did well after an adequate pyloromyotomy at reoperation. The conclusion is that pyloromyotomy is a most rewarding treatment for IHPS, that complications are rare and if occurring, can be dealt with without any lasting harm to the patient.

Gastric Mucosa↗
PubMed1982

Neutrophil function, serum opsonic activity, and delayed hypersensitivity in surgical patients.

The phagocytic function (e.g., phagocytosis, chemiluminescence, and chemotaxis) of polymorphonuclear leukocytes (PMNs), delayed hypersensitivity, and serum opsonic capacity were studied in 29 patients who underwent major surgical procedures, primarily abdominal surgery. The phagocytic capacity and chemiluminescence were normal in all patients as compared with healthy donors, and no difference in phagocytosis was found before or after operation. However, PMNs of 14 patients (48%) showed diminished chemotactic activity after surgery, but the influence of surgery on chemotaxis could not be demonstrated. About 30% of the patients had depressed delayed hypersensitivity after operation, as measured by skin testing using three recall antigens. The mean induration of the skin tests was 6.9 +/- 3.4 mm before operation and 3.6 +/- 2.9 mm thereafter (P = 0.006). The opsonic capacity of patient sera was measured as uptake by normal donor PMNs of staphylococci opsonized in patient serum. Eleven of 19 preoperative serum samples had an opsonic capacity comparable to that of normal control sera; the opsonic capacity of postoperative serum samples of the same patients was significantly decreased as compared with preoperative values. In seven patients the opsonic capacity of postoperative serum samples correlated with decreased levels of IgG in the sera but not with complement activity.

Adult↗
PubMed1981

Cytotoxic T cell response against lymphoblasts infected with Moloney (Abelson) murine leukemia virus. Methodological aspects and H-2 requirements.

A method for infection of lymphocytes with Moloney(Abelson) murine leukemia virus [M(A)-MuLV] is described. Only lymphoblasts obtained after stimulation of normal spleen cells by the B cell mitogen lipopolysaccharide (LPS) were satisfactory targets for virus-specific, secondary cytotoxic T lymphocytes (CTL), whereas spleen cells stimulated by the T cell mitogen concanavalin A were not. The secondary CTL response against M(A)-MuLV could be efficiently measured using M(A)-MulV-infected LPS blasts as stimulating cells for secondary in vitro restimulation and as target cells for virus-specific destruction. Cold target inhibition demonstrated virus specificity of CTL. The T cell character of the cytotoxic cells was demonstrated by their sensitivity to anti-Thy-1.2 treatment. Using syngeneic virus-infected LPS blasts as target and stimulator, CTL responses were measured with effector cells from C57BL mice of the H-2b haplotype and of recombinant haplotypes sharing either K or D alleles with H-2b. In analogy with previous studies on Moloney virus-specific CTL, it was observed that C57BL/6 (H-2b) effector cells predominantly lysed Db-compatible, virus-infected target cells; B10.A(5R), (KbDd) effector cells showed a poor CTL response against syngeneic, virus-infected target cells. The combined findings indicate the existence of an Ir gene in the H-2D region regulating the CTL response against Moloney leukemia virus.

Abelson murine leukemia virus↗
PubMed1981

Rhabdomyosarcomas: chemotherapy and limited supplementary treatment program to avoid mutilation.

A treatment program was set up to minimize mutilation in children with rhabdomyosarcomas (RMS) in the otorhinolaryngeal region, the urogenital tract, and other regions where surgery and radiotherapy (RT) could be mutilating. The primary treatment was chemotherapy with vincristine, dactinomycin, and cyclophosphamide, and each patient was assessed individually to determine whether supplementary treatment was needed. The initial results were so promising that a controlled clinical trial was undertaken by the International Society of Paediatric Oncology to compare the effects of chemotherapy alone versus chemotherapy and RT on the original tumor volume. At present, the place of irradiation in the treatment of RMS remains uncertain. It is unavoidable only in those patients who are likely to develop intracranial extension, because chemotherapeutic agents do not penetrate the blood-brain barrier.

Adolescent↗
PubMed1980

Role of metastatectomy without chemotherapy in the management of osteosarcoma in children.

In a series of 18 consecutive non metastatic osteosarcoma patients, metastases developed in 12 and successful metastatectomies could be performed in 6. No adjuvant chemotherapy was given. Four of these 6 patients survived. The importance of length of disease-free survival is described. Radiotherapy and chemotherapy as adjuvants to prevent or postpone the development of metastases are mentioned and an EORTC-SIOP trial on this subject is briefly discussed.

Adolescent↗
PubMed1975

Primary sarcoma of the aorta.

A 70-year-old man had an obstruction of the aortic bifurcation by a primary aortic sarcoma. The tumor was not fibrosarcomatous, as are the majority of primary aortic tumors. To our knowledge, this is the third occurrence of this type of primary aortic malignant neoplasm to be reported in the literature. A possible endotheliomatous origin is suggested.

Abdominal Neoplasms↗