Biomedical subjects
Publications and source records attributed to A Velasco.
Atherothrombosis is a key concept in our new pathophysiologic understanding of cardiovascular disease. It has led to new preventive strategies, both pharmacologic and lifestyle-related, to more specific treatments and to emerging imaging modalities.
Explore the source record for details and available documents.
The properties of some tricyclic and non-tricyclic antidepressants on antagonist histamine H1 and muscarinic acetylcholine receptors have been evaluated on guinea-pig ileum. They act like competitive antagonists on histamine H1 receptors. Some of them show a competitive antagonism and others a non-competitive antagonism on muscarinic acetylcholine receptors. A few of them are very potent antagonists on histamine H1 and/or muscarinic acetylcholine receptors, while others, especially the non-tricyclic antidepressants, have a small potency. All antidepressants have a higher histamine H1 activity than muscarinic acetylcholine activity. These results cannot explain the therapeutic effect of these drugs, but they can account for some side effects and drug interactions.
The antagonist effect of various antidepressants, both tricyclic and non-tricyclic, and of thiothixene on the histamine H2 receptors has been studied in the rat isolated uterus. All the drugs studied inhibit the effect of histamine, acting as competitive antagonists. Trimipramine and mianserin were the antidepressants which showed the highest activity, superior to cimetidine, whereas nomifensine, viloxazine, trazodone and maprotiline were those which showed the lowest antihistamine H2 activity. These results suggest that there is an interaction between antidepressants and histamine H2 receptors in rat isolated uterus similar to the interaction existing between antidepressants and histamine H2 receptors in brain and other tissues.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.