Biomedical subjects
Publications and source records attributed to A Varga.
Circulating immune complexes have been studied in 152 sera with PEG-precipitation nd with measurement of the complement activating capacity in a complement binding reaction with 51Cr-labelled indicator cells. A correlation was found between the results of both methods.
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For the evaluation of the results of thumb reconstruction no generally accepted guidelines exist. As a result, the following criteria are suggested: a test of tactile gnosis and a pick-up test (both tests performed without the aid of vision), two-point discrimination, subjective evaluation of the reconstructed thumb and the state of employment of the patient. A classification is proposed based on one or more of these criteria. With the osteoplastic method employing a pedicle flap, bone graft and island pedicle flap, resorption of the bone graft can be a problem. On the basis of the follow-up of nine patients, it was determined that the degree of resorption was inversely proportional to the time between the pedicle flap transfer and the implantation of the bone graft and directly proportional to the time between the bone graft and the transfer of the island pedicle flap. On the basis of these findings, five months are recommended between flap transfer and bone grafting and two months between bone grafting and island pedicle flap transfer.
A new radioimmunoassay for the detection of complement-binding immune complexes is described. The method is based on the ability of the complexes to bind added guinea pig complement (Clq-Component) so that is not available for lysis of 51Cr-labeled chicken red blood cells in a haemolytic system. Sera from 45 patients with malignant tumours, 20 patients with nonmalignant diseases were studied for the presence of circulating immune complexes. The complement-binding capacity of the sera of patients with significantly greater than that of control sera.
The leucocyte-adherence inhibition test was used on 24 patients with malabsorption syndrome, results being compared with those from patients with enteritis of other causes, and those with normal gastro-intestinal tract in order to test cellular gluten sensitization. The test makes it possible to distinguish between gluten-induced and non-gluten induced enteritis. There was a significant linear correlation to inflammatory activity as determined by biopsy as well as reduction in villous length and the villi-crypt index. The results suggest a primary T-cell dependent gluten (or gliadin) sensitization in the aetiology of coeliac disease.
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Leucocyte adherence inhibition was measured by a new modified radioisotopic technique. Peripheral blood leucocytes were isolated and labelled with Chrom51 (51Cr). These leucocytes were incubated with medium of buffer alone and with medium or buffer containing tumor antigen or gluten. The glass surface for the adherence was prepared carefully. At all samples the adherence of leucocytes occurred under the same conditions. The authors gave a report on the results of their leucocyte adherence inhibition (LAI) assay with gluten and stomach cancer antigen.
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In a group of patients with renal insufficiency in the chronic dialysis programme the K-cell-activity (antibody-depending cellular cytotoxicity) by means of 51-Cr-labelled chicken erythrocytes as target cells was determined and was found significantly decreased. The findings may be regarded as a sequel of the dialysis together with the already described T-lymphopenia. The reasons of this complex disturbance of the cellular immunity under conditions of dialysis are unknown.
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From 1968 to 1976, 89 flexor tendon injuries were reconstructed with bridging (mini-)-tendon grafts. This technique was also applied to injuries in "no-man's land". The results were better than with traditional tendon grafts. According to the criteria of BUCK-GRAMCKO there were very good and good results in 65% as compared to 51% with traditional tendon grafting. The method is recommended only for experienced hand surgeons.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.