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Biomedical subjects

A V Tsinzerling

Publications and source records attributed to A V Tsinzerling.

At least 37 records · Page 2Linked to original sources
PubMed1987

[Involvement of the afterbirth in influenza].

Light- and fluorescence-microscopy examinations of 186 placentas were carried out, with concurrent determination of placental interferon, isolation of influenza virus, and serologic tests of maternal and fetal blood, and amniotic fluid. In 32 of the cases, placentitis caused by serotype A or B of influenza virus was present, characterized by hyperplasia and subsequent destruction of amniotic cells, trophoblast, decidual cells, and vascular endothelium, by the presence of influenza antigens, fuchsinophilic cytoplasmic inclusions in the affected cells, and lymphoid infiltrates, and/or by circulatory disturbances. In addition, an interferon possessing properties of viral, immune, and placental interferon was detected in a number of placentas. A or B influenza virus was isolated from 3 placentas. Diagnostic titers of anti-influenza antibody occurred in fetal blood and amniotic fluid samples. The present results indicate that influenza virus may persist and replicate in placental cells.

Adolescent↗
PubMed1987

[Diagnosis of infectious diseases in the practice of pathologic anatomists].

A review of laboratory and morphologic methods currently used to study tissues in diseases caused by viruses, bacteria, mycoplasmas, fungi, and protozoa. Special attention is given to cytologic examination of smears and scrapings from viscera whereby valuable information that should be included in the death certificate can be obtained before histologic sections have been prepared and the laboratory examination has been completed.

Bacterial Infections↗
PubMed1987

[Streptococcal infection: variants and morphological manifestations].

82 cases of streptococcal infection (SI) in children who died in 1977-1985 are studied. Higher incidence of SI in children particularly in those who died at home is emphasized. As a rule, the proper diagnosis was not established clinically. By manifestations the observations were divided into two groups: 1) SI with a pronounced generalization including a pharyngeal one (31 cases), 4 of them with a rash (scarlet fever); extrapharyngeal (7 cases), 6 of them with a rash (scarlet fever); 2) SI without pronounced generalization (localized) including 33 cases with the involvement of the lungs and tonsilla and having an ordinary course and 11 cases of a sudden death. SI structural manifestations involved development of necrotic or purulent-necrotic inflammation of a various degree in the area of the primary focus, regional lymph nodes as well as in the foci resulting from lymphohaematogenic and intracanalicular dissemination. The first symptoms of the septic process could be found even in case of death during the first day of the disease. The role of viral respiratory infection being the background for the SI development, especially for its pharyngeal variant and lung affection, is shown. The significance of thymomegaly and adrenal hypoplasia in the development of a sudden death is revealed.

Child, Preschool↗
PubMed1986

[Current aspects of infectious pathology in infants and fetuses].

Analysis of biopsy specimen obtained at autopsies performed in hospitals for children from 1981 to 1984 are presented, as well as the results of goal-directed studies of some infectious diseases. It is noted that at adequate morphological and laboratory examinations the frequency of the diagnosed infectious diseases is rather high revealing mainly combined infections. The frequency of acute respiratory infections is especially high, as it is found in 3/4 of the nonsurvivors. There are viral, bacterial, Mycoplasma-induced and other diseases among them. The data on frequency and specific morphological features of different etiologic groups of infection, as well as separate diseases are given. Acute intestinal infections were less frequently diagnosed (in 9.8% of cases), coli-infection being predominant and appearing as a complication of different severe somatic diseases. Sepsis occurred rather frequently, though its rate was gradually decreasing (from 11.1% to 5.3%). Infections with predominant intracanal generalization were rare. Meningococcemia, developing, as a rule, in the presence of generalized viral infections, occurred in 2.2% of cases. Meningitis and meningoencephalitis, more often bacterial ones, complicating congenital malformations, were found in 4.5% of cases. Intrauterine infections, in particular caused by Mycoplasmas and viruses (cytomegalic, herpetic and respiratory ones) were very often diagnosed. They were associated with the same type of placental damage. Chlamydiosis, evidently frequent, was almost unidentified. Bacterial intrauterine infections including listeriosis were rare.

Bacterial Infections↗
PubMed1985

[Pathoanatomists--veterans of World War II 1941-1945].

During the Great Patriotic War, many pathologists, both pre-war professionals and those receiving the degree at a war-time, worked in the ranks of the Red Army. Moreover, many future pathologists who have got medical training after the war, participated in the battles with fascists aggressors as soldiers and officers of different kinds of troops as well as in the partisan movement. Prewar merits of the veterans in the field of pathology and their successful professional and administrative work after the war are listed. Likewise the achievements of pathologists who were soldiers or officers of the Red Army during the war and who after the war got their medical degree and became well-known scientists or clinical pathologists efficiently working in the Soviet public health, science and teaching, are recorded.

History, 20th Century↗
PubMed1984

[The placenta in herpes].

Forty placentas from patients affected with herpes simplex viruses of type I and II were studied by means of light and immunofluorescent microscopy, morphometry and serological investigation of fetal (infant) and mother's blood. Various morphological alterations in placenta were established. Some of them were specific and resulted from the effect of herpes virus on the cells (amniocytes, syncytiotrophoblast, decidual cells, vascular endothelium). The affected cells increased in size, herpes antigen was detected in their hyperchronic nuclei. Apart from this, in all placentas as well as in their vessels, moderate inflammatory response was observed. When antenatal death occurred, poor vascularization of villi was observed and specific alterations were most pronounced. When death occurred antenatally, alterations produced by herpes were rather moderate and acute alterations of placenta circulation predominated. In children born in a good condition, both specific and nonspecific alterations were insignificant and villi vascularization was good.

Adolescent↗
PubMed1984

[Features of the manifestations of bronchopulmonary pathology and hepatitis B in children with hypogammaglobulinemia].

Two cases of hypogammaglobulinemia (Bruton's syndrome) in brothers are described. Their sisters had no this disease. Pronounced changes in the lymph nodes, spleen and thymus typical for this condition were combined in both cases with lung and kidney malformations as well as with chronic pneumonia and inanition. The both boys have viral respiratory infections that followed by marked antibody formation and clear-cut structural alterations characteristic of different stages of these diseases. Besides this the older brother was found to have chronic viral hepatitis B with an unusual giant-cell reaction.

Abnormalities, Multiple↗
PubMed1983

[The nature of an inflammatory reaction as dependent on the etiology of infection and some peculiarities of the macroorganism].

The paper summarizes long-term studies on infectious pathology. On the example of the involvements of respiratory organs, the intestinal tract, and the central nervous system caused by viruses, bacteria, mycoplasma, fungi, and Protozoa, differences in the structural changes of the internal organs due to particular properties of the causative agents are analysed. These changes have been shown to be the greatest when the causative agents belong to different types and classes. The influence of host factors, first of all the immune status, on the course of infectious diseases is discussed. Changes occurring in the macro- and microorganism in the course of the infectious disease are considered. Not only local but also systemic defence mechanisms have been shown to be disturbed during infection which facilitates the occurrence of diseases of other etiologies and leads to increased incidence of combined infections.

Encephalitis↗
PubMed1982

[Incidence of intrauterine infections caused by respiratory viruses and Myc. pneumoniae and the role of serological studies in their diagnosis].

Examinations involved 40 stillborns and infants of up to 3 days of age using light and immunofluorescent (IF) microscopy, and the results obtained were compared with the data of clinical observations and serological examinations of the blood of infants and their mothers. The diagnostic titer of antibody determined by complement fixation and hemagglutination-inhibition tests was higher to respiratory viruses (1--4 in each baby) in 72.5% of babies and to M. pneumoniae in 17.5%. At a high antibody titer indicating a considerable duration of the disease, the results of IF studies were usually negative and the structural changes typical for individual infections of this group were insignificant or absent. This agrees with the results of previous studies of postnatally developing viral infections. At low antibody titres, in a number of cases the results of IF studies were positive and there were structural changes indicating a recent development of the disease. The possibility of antibody formation in fetuses was confirmed by selective studies of globulins in influenza A which proved to be M-globulins.

Adult↗
PubMed1982

[Effect of viral respiratory infections on the development and course of bacterial sepsis].

Sepsis was diagnosed in 9.5%-14.1% of fatalities in children. It was more frequently umbilical and caused by staphylococci, although of late mixed bacterial microflora was not infrequently detected. In 39 observations studied in detail sepsis was combined with acute respiratory infections (ARI) among which most important were viral respiratory infections (AVRI) as well as mycoplasmosis. The most important was the fact that AVRI not only were conducive to the generation of sepsis but caused its exacerbation. In the latter cases the development of fresh septic metastases was observed. This was associated with local (vascular damage) and general (disorders in the immunological status) changes in the patients arising as a result of AVRI.

Bacterial Infections↗
PubMed1982

[Viral appendicitis].

In order to study the appendix involvement with respiratory viruses in appendicitis, 44 cases of this disease in patients varying in ages from 14 to 71 years were investigated at random. Light microscopy and immunofluorescent examinations of the appendix were performed. The results were compared with those of serological blood tests done in the time course. In 20 patients the role of respiratory viruses and sometimes Mycoplasma pneumoniae proved to be doubtless by a significant rise in antibody titres (4-32-fold), as a rule, without any marked manifestations on the part of the respiratory organs. This was combined with detection of the antigen of the agent in enterocytes and with structural changes of the organ typical of these infections according to the results of previous examinations of the intestinal tract in generalized acute viral respiratory infections and mycoplasmosis. In 14 patients the role of respiratory viruses seemed to be likely. They showed positive results of immunofluorescent and light microscopy examinations without a significant rise in antibody titres, however. In 7 patients the role of respiratory viruses did not seem convincing: they had positive results of either immunofluorescence or serological tests alone. Three patients had no evidence of lesions caused by respiratory viruses or mycoplasma.

Adenovirus Infections, Human↗
PubMed1980

[Tonsils in diphtheria and the Corynebacterium diphtheriae carrier state].

Investigations of 16 archive autopsy observations of diphtheria of the fauces confirmed bacteriologically revealed that Corynebacteria diphtheriae multiplied mainly on the surface of the mucous membrane. Fibrinous inflammation on the tonsillar surface is most typical for this agent. In all cases with manifestations of acute inflammation the lesion was caused by C. diphtheriae in combination with other bacteria, most frequently streptococci. The latter were harboured deep in the tonsills and caused there an inflammatory process with characteristic lesions. Examinations of the tonsills removed from 72 C. diphtheriae carriers showed that longterm persistence of the bacteria in the tonsills was primarily due to the specific structure of the cryptae, particularly great branchiness and depth contributing to the retention of the content. Long-term carrier state leads to a statistically significant increase of the degree of their plasmatization as compared with the control group. This occurs in parallel with changes in the general responsiveness of the host.

Autopsy↗