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Biomedical subjects

A V Stepanov

Publications and source records attributed to A V Stepanov.

At least 37 records · Page 2Linked to original sources
PubMed1990

[Prolongation of the effect of immunostimulators as means of increasing resistance to causative agents of infection].

Possible prolongation of the biological effect of some available immunostimulators such as prodigiozan, salmozan, polyribonate and thymalin by their sorption on aluminium hydrate was studied. It was shown that in comparison to the native immunostimulators the sorbed ones had a more pronounced biological action and provided a more prolonged increase in the host resistance to the causative agents of gas gangrene and typhoid fever. Using prodigiozan as an example it was demonstrated that the observed increase in the anti-infective activity of the sorbed drugs was associated with more intensive stimulation of some immunological factors involved in regulation of host nonspecific resistance. The results of the study are likely to indicate that it was experiment to further investigate the drugs to reveal their efficacy in other infection models and to optimize the schemes of their use.

Adjuvants, Immunologic↗
PubMed1990

[The effect of immunostimulants on the resistance of white mice to the causative agent of typhoid fever].

The influence of prodigiosan, salmosan, polyribonate and levamisole on the body nonspecific and specific resistance to S. typhi strain 4446 has been studied. Prodigiosan and salmosan have proved to be the most effective. The injection of these compounds simultaneously with typhoid vaccine (both chemical adsorbed vaccine and alcohol-treated vaccine, enriched with Vi-antigen) significantly increases the survival rate of immunized animals (by 35-45%), elevates the resistance index (1.5- to 2.3-fold) and the effectiveness index of the vaccine (17- to 32-fold) in comparison with the controls. Besides, prodigiosan and salmosan alone are capable of increasing nonspecific resistance to S. typhi strain 4446, which is manifested by an increase of the survival rate of stimulated animals by 61.87%. Proceeding from the results thus obtained, the possibility of good prospects for prodigiosan and salmosan in the prophylaxis of typhoid fever in humans may be inferred.

Adjuvants, Immunologic↗
PubMed1988

[Selection of the method of cholangiography in cholestasis].

A statistical investigation of the effectiveness of endoscopic retrograde cholangiography in 223 patients and percutaneous transhepatic cholangiography in 204 patients was performed. In typical cases of obturative jaundice of unclear etiology the endoscopic retrograde cholangiography is recommended to patients with the level of general bilirubin lower than 10 mg%, percutaneous transhepatic cholangiography--to patients with the level higher than 10 mg%.

Bilirubin↗
PubMed1987

[The effect of polypeptides from the thymus, bone marrow and bursa of Fabricius on the immunogenesis and hemostasis in neonatally thymectomized and antenatally bursectomized chickens].

The effect of polypeptides from the thymus, bone marrow and bursa of Fabricius on immunogenesis and hemostasis was investigated in neonatally thymectomized and antenatally bursectomized chickens. It has been established that polypeptide factors from the bursa of Fabricius have the most pronounced effect on the immunity and hemostasis.

Animals↗
PubMed1986

[Effect of immunomodulators on resistance to gas gangrene. The enhanced resistance of white mice to perfringens toxin type A as affected by prodigiozan].

Experiments on 575 noninbred white mice have revealed that the nonspecific resistance of the animals to type A C. perfringens toxin can be enhanced by the administration of Prodigiosan, a commercial immunostimulating agent. Prodigiosan, introduced in 3-4 injections (the last one made 24 hours before intoxication) has been found to enhance the resistance of the animals to the subcutaneous injection of type A C. perfringens toxin by 40-60% and to its intraperitoneal injection by 60-97%.

Adjuvants, Immunologic↗
PubMed1984

[Determination of the topical organization of the discharges of identified mollusk neurons].

Identified RPa1, RPa2 neurons of the right parietal ganglion of Planorbis corneus were investigated. Coherent analysis of accumulated electrical activity in periferal nerves and spike discharges in identified neurons was done. Using this analysis, the presence of axon processes of RPa1 and RPa2 cells in the left and right pallial nerves was determined. Some polysynaptic pathways activated by discharges of these neurons were demonstrated. It is shown that the topical organization of the outputs of the investigated neurons remains invariant for different preparations.

Animals↗
PubMed1984

[Vectorcardiographic mapping in the evaluation of the severity of myocardial infarct].

Using the method of multidipol vector charting, the chronotopography of the potentials of the electric field of the heart in the precordial region was studied in 98 patients with acute myocardial infarction. Qualitative criteria of the severity of the course of myocardial infarction of various localization were obtained by using a phasic analysis of ventricular loops of vector cardiograms. The proposed method of vector cardiographic charting characterizes the functional status of the myocardium and may be used for determining the size of the necrotic zone in clinical and experimental conditions.

Adult↗