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Biomedical subjects

A Tosti

Publications and source records attributed to A Tosti.

At least 217 records · Page 12Linked to original sources
PubMed1990

Prevalence and sources of sensitization to emulsifiers: a clinical study.

737 patients with suspected cosmetic- or medicament-related contact dermatitis were patch tested with 6 emulsifier agents: triethanolamine, cetyl stearyl alcohol, sorbitan sesquioleate, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monooleate, and Amerchol L 101. 39 patients (5.3%) gave 1 or more positive patch tests to emulsifiers. A total of 54 positive reactions were found, 23 of which were clinically relevant, triethanolamine being the most frequent sensitizer. Patients with emulsifier sensitivity generally give a high prevalence of positive patch tests to other common ingredients of topical preparations, such as preservatives or active ingredients. Cosmetics and topical medicaments were detected as the source of sensitization in an equal number of patients. Patch tests with patients' own causative preparations were frequently negative. To avoid overlooking emulsifier sensitivity, it is advisable to test these compounds in patients with contact dermatitis that is possibly due to topical preparations, regardless of whether they have other clinically relevant positive reactions or whether patch tests with their own products are negative.

Administration, Cutaneous↗
PubMed1990

Cutaneous necrosis and calcinosis following electroencephalography.

The authors report 2 children who developed circumscribed dystrophic calcifications at the site of electrode placement after electroencephalographic examination. Deep cutaneous necrosis was a prominent clinical feature. A biopsy showed focal dermal calcification confirmed by a diffractometer analysis of a calcific granule. Cutaneous calcinosis is a possible risk of the usage of an electrode paste containing calcium chloride. Prolonged exposure and damaged skin seem to be prerequisites for this uncommon but harmful condition.

Calcinosis↗
PubMed1990

Massive lymphomatous nail involvement in Sézary syndrome.

The case of a 65-year-old man affected by chronic erythroderma due to Sézary syndrome and massive lymphomatous infiltration of the nails is reported. The clinical features of the nail lesions, consisting in thickening and discoloration of the nail plates, were not diagnostic. The nail biopsy showed a typical epidermotropic T cell lymphomatous involvement of all the nail constituents. Immunohistochemical characterization of the nails and skin lymphomatous infiltration showed identical results, confirming the neoplastic etiology of both the chronic erythroderma and the nail dystrophy.

Aged↗
PubMed1990

[Iso and Kikuchi syndrome. Description of a case].

A 2 1/2-year old Italian boy affected by Iso and Kikuchi syndrome is reported. The clinical examination showed hemi-onychogryphosis of both index fingers. Roentgenograms of the affected fingers showed bifurcation of the distal phalanges in the lateral view.

Child, Preschool↗
PubMed1990

Longitudinal melanonychia induced by 3'-azidodeoxythymidine. Report of 9 cases.

9 Caucasian patients who developed longitudinal melanonychia during 3'-azidodeoxythymidine (AZT) treatment for HIV infection are reported. The occurrence of nail pigmentation was not related to drug dosage or to the severity of the HIV infection. AZT as well as other drugs acting on DNA synthesis or transcription seem to be a quite frequent cause of longitudinal melanonychia.

Adult↗
PubMed1989

Hyposensitizing therapy with standard antigenic extracts: an important source of thimerosal sensitization.

The frequency of thimerosal sensitization was determined in 5 groups of subjects: military recruits; healthy subjects; patients with asthma or rhinitis undergoing hyposensitizing therapy with thimerosal-preserved antigenic extracts; patients with allergic contact dermatitis; patients with allergic contact conjunctivitis. Our patients with allergic contact dermatitis have a higher incidence of positive patch tests to thimerosal than healthy subjects. The source of thimerosal sensitization in this group remains obscure, their history of exposure to this or to other mercury derivatives being comparable to that of the healthy population. Patients with allergic contact conjunctivitis and patients receiving immunotherapy for asthma or rhinitis present a significantly higher frequency of thimerosal sensitization than the other groups, indicating that ophthalmic solutions and thimerosal-preserved allergen extracts are an important source of thimerosal sensitization. The clinical relevance of thimerosal sensitization was definitively established only in patients with allergic contact conjunctivitis, even though patients receiving immunotherapy frequently presented local reactions at the site of allergen inoculation.

Adult↗