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Biomedical subjects

A Tiilikainen

Publications and source records attributed to A Tiilikainen.

At least 109 records · Page 6Linked to original sources
PubMed1977

Acute anterior uveitis and HLA-B27 in families.

To determine the hereditary pattern of acute anterior uveitis (AAU) 12 families with 2 cases of AAU in each family were given a routine eye examination which included serological determination of HLA antigens. Members of four families underwent x-ray examination of the lumbosacral spine. Of the 23 cases with AAU examined, 19 had the antigen B27. The genes determining B27 and a2 were inherited together in 14 instances and the gene determining Cwl in 10 of these 14. The lymphocytes of the HLA identical siblings of the three families studied by the mixed lymphocyte culture test did not react against each other. Sacroilities was seen in 62.5% of cases with familial AAU and in 58.6% of their relatives. It is concluded that HLA-B27 is linked with genes predisposing the carrier to familial AAU, which is closely related to the rheumatic group of diseases.

Acute Disease↗
PubMed1977

HLA antigens in patients with juvenile diabetes mellitus, coeliac disease and both of the diseases.

We determined the prevalence of 24 antigens controlled by the HLA-A and B loci in twenty patients with juvenile diabetes mellitus (JDM), in twenty patients with coeliac disease (CD), and in eight patients with both of these diseases. The prevalence of HLA-B8 was increased in JDM chi2 = 12.52, p = 0.00040) and in CD (chi2 = 26.47, p less than 0.000001) as compared to 900 controls. There was only a modest increase of Bw15 in JDM (chi2 = 8.86, p = 0.0029) and in patients with both diseases (chi2 = 2.72). The observed prevalence of phenotype HLA-B8, Bw15 was enhanced in JDM (chi2 = 16.03, p = 0;000063) and in patients with both JDM and CD (chi2 = 24.48, p = 0.00000074) as compared with controls. In the latter group the observed value was 2.2 fold to that expected. In family studies the children having both B8 and Bw15 were more disposed to develop diabetes than siblings with only one of these antigens. In conclusion, the inherited susceptibility to develop juvenile diabetes is markedly associated with HLA-B8 and slightly with HLA-Bw15, and that of coeliac disease with HLA-B8 in Finnish paediatric patients. The presence of both B8 and Bw15 simultaneously increases the susceptibility to have both JDM and CD.

Adolescent↗
PubMed1976

HLA-compatible donor cornea for prevention of allograft reaction.

Our series comprises 80 penetrating grafts. Of the recipient corneas 36 were vascularized. Of the donor corneas 48 were fresh and 32 were cryopreserved. As prophylaxis, we gave topical and systemic prednisolone, combined, in heavily vascularized cases, with azathioprine. Corneal donor-recipient pairs were divided into three groups according to HLA histocompatibility. In Group I (0-1 mismatch) the rate of allograft reaction was 1 in 27, in Group II (2-4 mismatches) it was 4 in 19, and in the untyped Group III 9 in 34. Even when the prognosis was poor, a well-matched donor cornea (Group I) greatly improved the chances of success; when the corneal bed was vascularized, the well-matched donor corneas had a failure rate of 1 in 13, whereas in untyped pairs it was 7 in 18. The importance of possible presensitization is discussed.

Adolescent↗
PubMed1976

Inheritance of acute anterior uveitis and HL-A antigen 27.

A family study on the inheritance of HL-A antigens and susceptibility to acute anterior uveitis is reported. In the 4 families examined, the antigen 27 (haplotype 2.27) occurred in all of the 7 patients with acute anterior uveitis and in 22 of the 33 healthy family members examined. It is suggested that in Finns the haplotype 2,27 is linked with genes predisposing the carrier to acute anterior uveitis.

Acute Disease↗
PubMed1976

Histocompatibility antigens and dermatitis herpetiformis with special reference to jejunal abnormalities and acetylator phenotype.

Sixty-one patients with dermatitis herpetiformis (DH) were studied. Of these fifty-three (87%) had the histocompatibility (HL-A) antigen HL-A8 as compared with 17% of a control population; the difference is significant. This incidence of HL-A8 among patients with DH is higher than that reported earlier for such patients and is similar to that reported for patients with adult coeliac disease. The incidence of HL-A1 was also significantly greater in the patient group, and was attributed to the increased frequency of haplotype HL-A1, 8. The frequency of HL-A8 was about equal in patients in whom DH was associated with jejunal abnormalities and in those in whom it was not. When correlated with rate of acetylation, there was no significant difference in the occurrence of various HL-A antigens.

Acetylation↗
PubMed1976

Family studies in dermatitis herpetiformis.

Six families were studied which included 11 members with dermatitis herpetiformis (DH) and three with coeliac disease (CD). Proximal jejunal biopsies performed on 20 relatives revealed villous atrophy in eight. Of these eight, two, both siblings of patients with DH, had a history of juvenile CD. Determinations of histocampatibility (HLA) antigens showed that HLS-B8 occurred in all six families although two patients with DH and one relative with a history of juvenile CD lacked this antigen. In one family the haplotype A1,B8 was associated with DH, villous atrophy, juvenile diabetes and Addison's disease. Skin biopsy failed to reveal IgA in any of the 44 relatives studied for this immunoglobulin. Antireticulin antibody was detected in the sera of seven (17%) relatives.

Adolescent↗
PubMed1975

Massive invasion of fetal lymphocytes into the mother's blood at induced abortion.

The proband, a healthy primipara, selected for study after she had asserted that she had not previously been pregnant, gave birth to a healthy girl with the karyotype 46,XX. In the 21st week of gestation, leukoagglutinin-stimulated mitoses from the proband's blood were 99% 46,XX and 1% 46,XY, the Y chromosome being identified by its quinacrine fluorescence. In two samples taken later in pregnancy no XY mitoses were found in the cultures, but on all three occasions brightly fluorescent Y chromatin in a proportion of the uncultured lymphocyte nuclei showed teh presence of XY cells in the proband's blood. High titers of cytotoxic anti-HL-A 3 were detected in the maternal serum before and after delivery. Our tentative interpretation is that the XY cells in the proband's blood emanated from a previous fetus that was legally aborted by curettage on the 10th week of an uneventful pregnancy and which the patient admitted to only after repeated questioning.

Abortion, Induced↗
PubMed1975

LD antigens associated with HL-A8 and myasthenia gravis.

The finding that the SD antigen HL-A8 is associated with myasthenia gravis has raised the question as to whether or not there is also an association between some specific LD antigen and myasthenia gravis and/or HL-A8. MLC technique was used to study LD antigens in 33 myasthenic patients. The cells of a myasthenic patient who was homozygous for both HL-A and LD products were used in MLC tests as stimulators with HL-A8 bearing cells from 24 myasthenics, their 17 relatives and 16 controls and to non-HL-A8 cells from nine myasthenics and 16 controls. At least three different LD genes were found to be associated with HL-A8. One of them, called LDm' was present in 17 (63 %) of the 27 HL-A8-bearing haplotypes of myasthenics, and in nine (47 %) of the 19 HL-A8-bearing haplotypes of controls. In our study LDm was not found in the 84 haplotypes devoid of HL-A8. LDm is strongly associated with HL-A8 and through this also with myasthenia. Calculated from phenotype frequencies for HL-A8 and its association to LDm' the LDm frequencies are 9 % in the control population, 30 % in myasthenics and 48 % in young females with onset of myasthenia below 35 years. LDm had no indendent correlation with any of the clinical parameters of myasthenia gravis, even though is was found more often in HL-A8+ females with the onset of myasthenia before 35 years than in the whole myasthenic group. LDm appears to be similar to LD8a antigen.

Age Factors↗
PubMed1975

HLA antigens.

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Arthritis, Rheumatoid↗
PubMed1975

HL-A antigens in patients with persistent palmoplantar pustulosis and pustular psoriasis.

HL-A typing was performed in a series of 22 patients with persistent palmoplantar pustulosis, 14 patients with palmoplantar pustulosis and psoriasis, 15 patients with generalized pustular psoriasis and 45 patients with uncomplicated psoriasis. None of the patients with persistent palmoplantar pustulosis alone had relatives with psoriasis, which was a common finding in the other groups. The HL-A antigens 13 and 17 were markedly increased in the group of uncomplicated psoriasis. In the group of patients with persistent palmoplantar pustulosis alone neither of these antigens was increased, as compared with a control population. Four patients with persistent palmoplantar pustulosis and psoriasis had HL-A 17 or 13 and two patients with generalized pustular psoriasis had HL-A 17. In the latter group HL-A 27 occurred in eight cases and correlated with the presence of sacro-iliitis. It was concluded that persistent palmoplantar pustulosis is an entity genetically distinct from psoriasis even if psoriatic patients might have an increased tendency to develop this type of pustular reaction.

Dermatitis↗
PubMed1975

Circinate erosive balanitis and HL-A 27.

The HL-A phenotype of 17 patients with a typical clinical picture of circinate erosive balanitis was determined. Eight of the patients had other signs of Reiter's disease and 9 had balanitis alone. HL-A 27 was found to be present in 15 of the 17 cases. One patient of each group lacked this antigen. The frequency of the other histocompatibility antigens did not significantly differ from that of a Finnish control population.

Adolescent↗