No significant association between HLA and nickel contact sensitivity.
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Adolescent↗
Biomedical subjects
A Tiilikainen
Publications and source records attributed to A Tiilikainen.
Fuchs' heterochromic cyclitis associated with retinitis pigmentosa: a family study.
To determine the hereditary, clinical histopathological aspects of the association between Fuchs' heterochromic cyclitis (FHC) and retinitis pigmentosa (RP), the family of a patient with FHC and bilateral RP was studied genealogically, ophthalmologically and immunogenetically. The oldest brother and the youngest sister of the proband had bilateral RP and glaucoma which in the brother lead to enucleation of an eye which was studied histologically. The proband, his brother with RP, and 2 of their healthy siblings were homozygous for the haplotype A3, B7, w6. The parents of the siblings were healthy, and the pedigree showed much parental consanguinity and indicated autosomal recessive inheritance of RP.
Adult↗
HLA-B18 antigens and protection from pulmonary fibrosis in asbestos workers.
HLA antigens were identified in 64 patients with radiographic asbestosis and 37 matched controls with equivalent asbestos exposure but no radiographic pulmonary fibrosis. A high prevalence of HLA-B18, B27 and Cw2 was found in the controls. This result might indicate that the possessors of these HLA antigens are thus protected from the development of diffuse pulmonary fibrosis from asbestos exposure. Signs of susceptibility were not demonstrated. The radiographic severity and progression of asbestosis were not associated with any of the HLA antigens tested.
Adult↗
High frequency of agranulocytosis in breast-cancer patients treated with levamisole.
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Agranulocytosis↗
HLA-Dw2 as a marker of resistance against juvenile diabetes mellitus.
Juvenile-onset diabetes mellitus (JDM) is one of the human diseases shown to be associated with histocompatibility antigens. The occurrence of serologically defined HLA antigens B8 Bw15, B18 and Cw3 is increased among these patients (Singal & Blajchman 1973, Nerup et al. 1974, Cudworth & Woodrow 1975). However, lymphocyte defined HLA-D antigens Dw3 and Dw4 (LD 8a and LD w15a), positively associated with these serologically defined antigens, seem to be even stronger markers of susceptibility to this disease (Thomsen et al. 1975).
Cytotoxicity Tests, Immunologic↗
HLA-B 12 and HLA-B 27 antigens and susceptibility to the corneal allograft reaction.
Our series comprised 100 penetrating corneal transplantations: 36 cases with HLA-B 12 and/or B 27 antigen in the recipient and, as controls, 64 cases without these antigens. The cornea was vascular in 44% of the HLA-B 12/B 27 group and in 40% of the controls. In the HLA-B 12/B 27 group AR developed in 13 of 36 cases, 36%; but in the control group only in one case (2%). In vascular and avascular cases the incidence of AR was equal. Among the high-risk cases of the HLA-B 12/B 27 group with definite mismatching of B 12 or B 27 antigens, 9 of the 14 recipients had developed AR. Six further recipients of this group had untyped grafts, and AR occurred in 4 of the 6, but in none of the 16 cases that were matched for B 12 or B 27 antigens. The value of a compatible graft, at least to the carriers of HLA-B 12 and/or B 27 antigens, is thus confirmed.
Adolescent↗
Genetic background of Fuchs' heterochromic cyclitis.
We studied the genetic background of 24 patients with Fuchs' heterochromic cyclitis (FHC). Each was given a careful eye examination which included family history and serological determination of HLA antigens. Two families each had 2 cases of FHC in the same family; in addition an ancestor in the second family possibly had FHC; in both families one healthy member had simple heterochromia. One patient with FHC had congenital uveal coloboma, one pigmentary retinal dystrophy, and four had cysts of the ciliary body. The frequencies of all HLA antigens in patients with FHC compared well with the frequencies in the controls. In a family in which HLA haplotypes could be derived, the patients with FHC showed different HLA haplotypes. We conclude that FHC has a hereditary basis but its immunological component is not genetically associated with the HLA system.
Adolescent↗
Herpes gestationis. A high titre of anti-HLA-B8 antibody in the mother and pemphigoid-like immunohistological findings in the mother and the child.
A mother with herpes gestationis and her child without cutaneous lesions had analogous immunohistological findings. In the skin they had deposits of IgG and C3 component of complement at the basement membrane zone. Circulating IgG antibody to the basement membrane was also demonstrated in both. The mother also had a high titre of anti-HLA antibody against a histocompatibility antigen (HLA-B8) present in the child. A possible role of this HLA antibody in the pathomechanism of herpes gestationis is discussed.
Adult↗
The effect of HLA antibodies on platelet aggregation.
Twelve different HLA antisera, detecting antigens of both A and B series and the superspecificities w4 and w6, were tested for platelet-aggregating activity in 75 antiserum-platelet combinations. The correlation between the HLA specificities of the antisera and the aggregating effect on platelets carrying the corresponding antigens was significant (P = 0.011). Because the platelet aggregation test is being used for screening of circulating immune complexes, falsely positive reactions caused by HLA antibodies must be eliminated by adequate control experiments.
Antibody Specificity↗
Polio antibodies and HLA antigens in amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis (ALS) is a fatal, progressive disease of the central nervous system. Its possible association with poliomyelitis was studied by measuring neutralizing antibodies against polio virus types 1, 2 and 3 in the sera and cerebrospinal fluids of 11 ALS-patients, but antibody titers did not markedly differ from those of the controls. The HLA antigens of 12 ALS patients were also determined, in order to reveal any possible genetically-determined susceptibility to the disease. Possible association of ALS with HLA-Bw40 was noted. In addition, the Bw40 antigen seemed to be associated with milder progression of the disease. The lymphocytes of the ALS patients seemed defective in their capacity to stimulate allogenic lymphocytes, possibly due to a relative decrease of B cells in the peripheral blood. Joint efforts of study groups of neuroepidemiology, immunology and genetics should be mobilized to reveal the true nature of these findings.
Aged↗
HLA-B27 in rheumatoid arthritis and amyloidosis.
To study the role of genetically determined immune responsiveness in the pathogenesis of systemic amyloidosis complicating rheumatoid arthritis the HLA antigens were identified in 26 patients with rheumatoid arthritis complicated by secondary amyloidosis, in 44 patients with rheumatoid arthritis, and in 11 patients with secondary amyloidosis of non-rheumatoid origin. Subjects with ankylosing spondylitis, sacroiliitis without peripheral polyarthritis, Reiter's disease, reactive arthritis, erosive osteoarthritis, psoriatic arthropathy, systemic lupus erythematosus or arthritis associated with a gastrointestinal involvement were excluded from the study. Patients with amyloidosis secondary to rheumatoid arthritis had a high frequency of the HLA specificity B27 and of the haplotype likely to bear A2, B27. The association with B27 was closest in the group of male patients with amyloidosis whose rheumatoid arthritis had begun at an early age and who lacked demonstrable rheumatoid factor in serum. These patients may represent a genetically determined subentity of rheumatoid arthritis.
Adolescent↗
Hereditary angioneurotic edema (HANE): Lack of close linkage between HLA haplotypes and C1 esterase inhibitor deficiency.
The HLA haplotypes were defined in a series including 11 patients with hereditary angioneurotic edema (HANE), five symptom-free subjects with pathological laboratory findings characteristic of HANE, and their 33 healthy kinsmen. The subjects belonged to two Finnish families representing the more common form of HANE which is recognized by the immunochemically observed decrease of the inhibitor (C1-INH) blocking the esterase activity of the first complement component. No linkage between HANE and the HLA system was found.
Adolescent↗
HLA antigens and antibody responses to measles and rubella viruses in multiple sclerosis.
Twenty-four HLA-antigens coded by loci A and B were determined serologically for 60 multiple sclerosis patients from Northern Finland. Forty-five of the patients were also typed by mixed leucocyte culture reactivity for HLA-Dw2. The only statistically significant difference in antigen frequencies in these patients compared with those in controls was the decrease of HLA-A2 among patients. Measles and rubella antibody titres in patients with and without HLA-Dw2 and HLA-B7 antigens were compared using a sensitive radioimmunoassay method. There was no difference between age- and sex-matched patient groups.
Adult↗
Mixed lymphocyte culture reactions at delivery and in the puerperium: effects of parity, HLA antigens and maternal serum.
Mixed lymphocyte culture reactions between maternal and related neonatal cells at delivery, and maternal and paternal cells about a week after delivery, and the effect of maternal serum and HLA antigens on these reactions were studied in 11 families with primiparous or secundiparous mothers and in 13 families with multiparous mothers (six or more pregnancies). Weak or absent MLC response of the mother to her infant was observed in one-third of primiparous and secundiparous mothers and in one-half of multiparous mothers. In some cases the non-reactivity could be due to genetic similarity, i.e. HLA or HLA-D identity between the mother and her infant. In other cases, this was obviously not a valid explanation and no apparent reason for the non-reactivity was found. The MLC suppressing effect of maternal serum on MLC reactions at delivery and about a week later was not correlated with the strength of maternal-neonatal MLC reaction. Four of the ten sera from multiparous mothers studied a week after delivery had an inhibitory effect of 50% or more on MLC reactions involving stimulatory paternal cells. Responding paternal cells and other MLC combinations were also inhibited to varying degrees. None of the sera of primiparous and secundiparous mothers had an equally strong MLC inhibiting effect.
Adult↗
HLA phenotypes in patients with rheumatic fever, rheumatic heart disease, and Yersinia arthritis.
HLA phenotypes were determined in 109 patients with rheumatic fever (RF), 48 patients with Yersinia arthritis (YA), 86 patients with chronic rheumatic heart disease (RHD), and 326 controls. There was an increased frequency of Bw35 in RF as compared to controls (Pc less than 0.01), while B18 was more common in patients with acute carditis than in those without (P less than 0.02). HLA frequencies in RHD did not differ significantly from those in controls. A significant correlation between B27 and YA was observed (Pc less than 0.001). Carditis or iritis occurred in 10 of 31 B27 positive YA patients but in none of 17 B27 negative patients. Eleven of 31 B27 carriers had signs of urological inflammation vs one of 17 B27 negative patients. In the B27 positive YA group, there were three men with previous ankylosing spondylitis and one with Reiter's syndrome (RS). Also, four patients developed RS during Yersinia infection. This simultaneous occurrence of three B27 positive rheumatic diseases suggests that a patient with one "B27 positive rheumatic disease" is more susceptible to other diseases or symptoms known to be associated with the B27 antigen.
Adult↗
HLA determination in renal transplantation with living donor.
During the period Feb. 1967--Aug. 1976 94 first renal transplantations were performed using living related donors and histocompatibility tests. Eight transplantations were performed on children under 15 years old and four on patients over 50 years old. The rest of the patients were between 15 and 50 years old. No exclusions were performed. 22 patients expired, seven of these with a well functioning graft. The patient survival (P.S.) was 90% at 1 year, 87% at 2 years and 77% at 5 years, the graft survival (G.S.) was 81% at 1 year, 80% at 2 years and 68% at 5 years. The clinical results showed a fairly good correlation with the histocompatibility degree. In the A-B-match groups the 1, 2 resp. 5 years P.S. was 95, 96 resp. 89% and G.S. 90, 90 resp. 89%. In 43% of the patients rejection of variable degree developed. The rejection led to graft loss in 12%.
Adolescent↗
Transfusion and kidney graft survival in Finland.
The influence of blood transfusions prior to kidney transplantation on graft survival was analyzed in a series of 406 first transplantations, including 321 necro-kidneys. Among the 131 females with necrokidneys, 14 had not been pregnant or received transfusions, neither had 70 of the 190 male necrokidney recipients been transfused. In comparison with these controls, a slightly better graft survival was observed in the "immune-triggered" patients, especially in those with no detectable lymphocytotoxic antibodies before transplantation, and more markedly in female than in male patients. The effect of pregnancies seemed the same as that of transfusions. The age and pretransplantation dialysis treatment of the recipient appeared irrelevant to graft survival. "Immune-triggering" slightly improved graft survival also in the living donor category.
Blood Transfusion↗