[Unusual cause of a root irritation syndrome].
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Biomedical subjects
Publications and source records attributed to A Thron.
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Using water-soluble contrast media for thoracic myelography vascular structures can be outlined within the subarachnoid space in about 30% as distinct and in another 30% as faint contrast filling defects. The localization corresponds to the results of anatomical studies demonstrating the largest vessels in the lower thoracic region and at the lumbar enlargement. The extreme variability of size and course of spinal cord vessels can cause difficulties in separating normal and angioma-like vascular pattern in myelographic examinations. Out of 100 unselected cervico-thoracic myelographies, examples of normal vascular patterns are given and compared to pathological findings of angiographically verified angiomatous malformations. The limitations of diagnostic reliability are given by anatomical factors like variability of vessel size or width of the subarachnoid space, by secondary spinal arachnitis or by the differentiation of cord tumours with vascular congestion. Furthermore, inadequate angiographic studies can result in misinterpretation of myelograms. In cases of negative arteriograms other affections leading to raised pressure in the azygos- or caval vein should be considered.
Five cases of brain abscess were treated conservatively with antibiotics only. Possibilities and limitations of nonsurgical cure of focal intracranial infections are discussed. Different formation of brain abscess during conservative management are shown with the aid of serial computer tomography. The value of non-invasive CT follow-up studies is compared with other conventional neuroradiological investigations.
The CT features of a young female patient suffering from systemic candidiasis with intracerebral manifestation are reported. The definite diagnosis was made by spinal fluid cultures. The diffuse granulomatous lesions as well as an abscess formation remitted after specific therapy with 5-fluorocytosine and amphotericin B for now more than 1 year. In contrast to reports of other cases with mycosis of the central nervous system this case of candidiasis shows lesions of primarily increased attenuation coefficients.
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Twelve cases of venous angioma of the brain are presented. The neuroradiological and clinical findings in our series as well as in 45 previously reported cases are summarized. Angiography shows a normal arterial phase but consecutively a network or medusa-like pattern of numerous dilated medullary veins. converging towards one or several draining vessels with transcerebral course. The angiographic appearance is characteristic but not uniform, showing subgroups with faint blush, early filling veins and drainage into different directions. Some cases of venous malformations cannot be classified on the basis of angiographic findings and differentiation of telangiectases or cavernomas may be difficult. CT findings are non-specific, but contrast-enhanced CT almost invariably shows an enlarged transcerebral vessel, suggesting the presence of venous malformation. The lesion has to be classified as a vascular hamartoma. Although not an uncommon finding at autopsy venous angioma has been considered rare, because its clinical and radiological characteristics are little known. Though it may be asymptomatic, more than 30% of the reported cases (50% in our series) suffered from epileptic seizures. In about 10% of all cases symptoms of intracranial hemorrhage related to venous angioma were observed.
Technical and methodological procedures as well as results and follow-up studies of superselective angiographies and embolisations with different materials (gelfoam, lyophilised dura, silicone-elastomer) in 105 patients with vascular lesions (arteriovenous angiomas and fistulas, capillary haemangiomas), benign (glomus tumors, fibromas, meningeomas) and malignant tumors (sarcomas, metastases) of the cranio-facial region are described. Due to the clinical findings and follow-up studies up to three years there were different palliative and curative results which are exemplified. Therefore, a uniform performance of the embolisatory interventions is refused. The arterial approach, the different catheter systems as well as the actual technical procedure of the embolisations, with or without superselective pharmacoangiographies, has to be chosen according to the individual manifestation of the lesions and their anatomical and pathological conditions.
Percutaneous transluminal balloon-catheter dilatation successfully removed the stenosis in three out of four patients with obstruction of a subclavian artery. The arm oscillogram became normal and after an average of four months later the three patients remain without symptoms. The method is particularly suitable, as an alternative to operative intervention, if the stenosis is in the proximal part of the subclavian artery.
Giant intracranial aneurysms of the vertebral and basilar artery can be mistakenly diagnosed as neoplasms of the posterior fossa on the basis of their clinical presentation and CT findings. The following report of three cases of tumorous aneurysms emphasizes the complementary value of angiography and computed tomography for the localization and correct diagnosis of space-occupying lesions of the posterior fossa.
Twenty-seven cases of complete subarachnoid block discovered through myelography are analysed with regard to the causes of obstruction, the neurologic symptoms, and the cerebrospinal fluid. The neurologic signs in cases of cauda equina compression, most often caused by massive disc protrusions (20 patients), vary considerably and rarely correspond to the gross myelographic findings. Bilateral neurologic symptoms of any degree with or without sphincter disturbance were observed in 21 among 27 cases and are signs of cauda compression. In contrast to cases of sciatica with unilateral root compression and radicular symptoms neurological symptoms are not reliable in revealing the site of the lesion in cases of massive central disc protrusions. Therefore radiculography (myelography of the cauda equina) is necessary for diagnosis. In addition to the well-known elevation of the spinal fluid protein and pleocytosis, the presence of neutrophile granulocytes is frequently found (11 of 20 cases) in cytological analysis.
Dyschondroplasia is a mesodermal dysplasia with typical skeletal malformations of varying extent and severity. The combination with other malformations has led to numerous disease entities (Maffucci's syndrome, M. Kast, M. Ollier) that should be regarded as different forms of the same syndrome. The importance of the rare disease lies in the high risk of sacomatous transformation of the skeletal lesions and furthermore in an increased risk of development of other tumours. Involvement of the central nervous system is possible through lesions of the bones of the skull or through primary intracranial tumours. The present report concerns a patient with dyschondroplasia complicated by the occurrence of a cerebral glioma and is the third reported case verifed by biopsy.
A standard myelogram using water soluble contrast with additional functional examination were carried out on 72 patients with suspected disc prolapse. Diagnostic accuracy can be significantly improved by the functional examination and, in some cases, the diagnosis can only be made in this way. There are no false positives. The advantages and limitations of the method are enumerated and its morphological significance is discussed.
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A case of a patient with multiple bilateral hamartomas of the kidneys is reported. The diagnosis of polycystic renal disease, suggested by the urographic studies had to be corrected after renal angiography. A well established diagnosis, basing on the striking angiographical findings was only possible, when we took notice of an adenoma sebaceum and other signs of the tuberous sclerosis complex. In cases of circumscribed unifocal lesions the antiographic findings may cause difficulties in the differential diagnosis between hamartoma and malignant hypernephroma. Therefore it is important to pay attention to other stigmata of tuberous sclerosis (Bourneville-Pringle's-syndrome). The differentiation between benign hamartoma and malignant hypernephroma may be possible by angiographic criteria alone, but many of the reported typical signs are of limited value.
Strokes in children occur in conjunction with arteriovenous malformations or with occlusive vascular diseases secondary to cardiac disease, intracranial infection, hematological and metabolic disorders. Recently several inborn errors of metabolism have been recognized as possible causes of strokelike events and should be considered in differential diagnosis. In a survey we describe our experience with stroke and strokelike episodes in childhood and discuss the approach selected for its management.