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Biomedical subjects

A Taylor

Publications and source records attributed to A Taylor.

At least 883 records · Page 49Linked to original sources

The velocity of lymph flow in the canine thoracic duct.

1. The velocity and pattern of movement of lymph in the thoracic duct of anaesthetized and conscious dogs has been studied by observing the movement of droplets of ultrafluid lipiodol in the duct.2. The velocity of flow when anaesthetized varied from 0.1-2.0 cm/sec, to 5.0 cm/sec when conscious.3. The pattern of flow was affected by respiration and the cardiac cycle. Most movement occurred at the end of inspiration.4. The duct of five autopsy preparations was perfused with saline to assess the volume and velocity of flow produced by the level of pressure gradients previously observed in the duct. These studies show that the small gradients (2-5 mmHg) observed during life are more than sufficient to produce the normal volume and velocity of flow measured. The mean resistance of the duct was 0.5 mmHg/ml. min.

Animals↗

The projection of the vestibular nerve to the cerebral cortex in the cat.

1. The cerebral cortex in the cat has been examined for responses to contra-lateral vestibular nerve shocks and to natural stimuli.2. Stimulation of the nerve produces short latency (3.5 msec) surface positive responses in very restricted areas. Within these areas, unitary discharges occur during the equivalent negative phase below the surface.3. It has not been possible to evoke unitary activity in these areas by natural stimulation during light anaesthesia with pentobarbitone, chloralose or urethane.4. The distribution and properties of the shock evoked responses have been studied with special attention to the problem of stimulus spread. They are shown to be overlapped by somato-sensory and auditory projections, but to be distinguishable from them. Evidence is presented that previously reported longer latency responses were probably due to stimulus spread.5. Reasons are discussed for the extreme sensitivity of the vestibulocortical pathway to anaesthesia.

Anesthesia, General↗

Vasopressin: possible role of microtubules and microfilaments in its action.

Colchicine, vinblastine, podophyllotoxin, and cytochalasin B inhibit the action of vasopressin and cyclic adenosine monophosphate on osmotic water movement across the toad bladder. The findings suggest that microtubules, and possibly microfilaments, play a role in the action of vasopressin, perhaps through involvement in the mechanism of release of secretory material from the bladder epithelial cells.

Animals↗