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A Taube

Publications and source records attributed to A Taube.

96 records · Page 6Linked to original sources
PubMedDate not supplied

Sensitivity, specificity and predictive values: a graphical approach.

The relation between sensitivity, specificity and prevalence is illustrated by means of a graphical device, applied to two diagnostic questions on gastroenteritis in children. The relation between the predictive values and the prevalence is also illustrated graphically.

Biometry↗
PubMedDate not supplied

Suramin inhibits the growth of human breast cancer cell lines. Studies on parental lines and corresponding sublines with acquired doxorubicin resistance with and without expression of P-glycoprotein.

Suramin at 100 to 800 micrograms/ml caused a dose dependent growth inhibition in three (Zr-75-1, BT 549 and HS-578T) parental human breast cancer cell lines and their corresponding sublines with acquired doxorubicin (dox) and multi-drug resistance. The effect was significantly more marked after 7 days suramin exposure compared with 3 days. The oestrogen and progesterone receptor rich cell line Zr-75-1 was more responsive to suramin compared with the other two lines. The sublines Zr-75-1-dox and HS-578T-dox with an increased expression of the permeability glycoprotein (P-gp) demonstrated a significantly decreased cell survival compared with corresponding parental cell lines at 3 and 7 days exposure of suramin, respectively. The subline BT 549-dox with multi-drug resistance without P-gp expression had a significantly impaired response after 3 days suramin compared with the parental line. These results indicate that suramin may be a potential therapeutic agent for the breast cancer patients with P-gp expression and multi-drug resistance.

ATP Binding Cassette Transporter, Subfamily B, Mem↗