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Biomedical subjects

A Taieb

Publications and source records attributed to A Taieb.

At least 91 records · Page 5Linked to original sources
PubMed1985

Prognosis in juvenile dermatopolymyositis: a cooperative retrospective study of 70 cases.

A retrospective multicenter study was conducted with 70 patients with juvenile dermatopolymyositis. Among survivors with sufficient follow-up (at least two years), a good prognosis subgroup was characterized by significantly better (P less than 0.001) initial response to steroids and less frequent pharyngeal involvement when compared to other patients in a poor prognosis subgroup with significant sequelae or still active disease. Patients who died had more severe pharyngeal involvement than those who survived (P less than 0.05).

Adolescent↗
PubMed1983

[Pheochromocytoma and its diagnostic pitfalls].

A sixty-year-old man experienced successively over two years several episodes of circulatory collapse and meningeal hemorrhage, a myocardial infarction, an episode of ketoacidosis and a seizure before acute abdominal pain with fever related to the sudden, partial, necrosis of his tumor, led to the discovery of a pheochromocytoma. This observation exemplifies the multiple clinical aspects and diagnostic pitfalls of this secreting tumor. It underscores the misleading nature of normotensive pheochromocytomas.

Adrenal Gland Neoplasms↗
PubMed1983

[Atopic dermatitis].

Explore the source record for details and available documents.

Adrenal Cortex Hormones↗
PubMed1977

[Early gastric carcinoma. 20 cases. Radioclinical, endoscopic and histopathological study (author's transl)].

The authors report twenty cases of early gastric carcinoma: superficial and with limited infiltration. The histological appearances varied, related to the macroscopic type of the tumour: protuberant, ulcerated, flat. The slightest clinical symptoms justify the most careful radiological study. Protuberant types result in a filling defect. Ulcerated types have a characteristic appearance of superficial ulcer, the folds involved being nodular or widely spread. Deeper regressive ulcerations are sometimes seen in association. Flat forms after the folds of a localised area of mucosa. The differential diagnosis is difficult. It is particularly important to eliminate the possibility of a benign ulcer, polypoid gastritis, lymphoid superficial ulcer, atrophic gastritis, well healed benign ulcer. Combined radiological and endoscopic studies are essential at all stages.

Aged↗
PubMedDate not supplied

Thalidomide neuropathy: an electrophysiologic study.

Thalidomide is effective in the treatment of such disabling dermatologic diseases as aphthosis, discoid lupus erythematosus, and prurigo nodularis, in which other drugs fail. However, its use can induce neuropathy necessitating caution in its administration. It was found in this electrophysiologic study of 13 patients that the data best revealing neuropathy, even when clinical abnormalities were not apparent, were reduction of sensory nerve action potential amplitude on the sural nerve, increase of somatosensory evoked potential latency following sural nerve stimulation, and reduction of sensory action potential amplitude on stimulating the median nerve at the wrist. In two patients, electrophysiologic abnormalities had increased after withdrawal, suggesting a prolonged action of thalidomide. Timely reduction of dosage, after detection of changes indicating the onset of side effects, could reduce the risk of the sometimes rapid emergence of clinical symptoms.

Action Potentials↗
PubMedDate not supplied

[Persistant mucosal ulcerations: a rare complication of toxic epidermal necrolysis].

INTRODUCTION: Sequels can be observed in toxic epidermal necrolysis. Persistence of mucosal ulcerations is not a classical complication of this disease. We describe two case reports of mucous membrane ulcerations (oral and genital) which have remained many months after the acute phase of toxic epidermal necrolysis. CASE REPORTS: Case 1. A little girl, 9 years old, was referred for a chronic and painful ulceration of the vulva that had appeared 9 months earlier during a toxic epidermal necrolysis. She presented a clearly crircumscribed vestibular ulceration. The mucosal biopsy was refused by the family. The genital erosion persisted more than one year after the acute phase. Case 2. A 73 year-old man was referred for a persistent and clearly circumscribed lingual ulceration, 9 cm in diameter. This chronic ulceration had appeared 3 months earlier, during the acute phase of a toxic epidermal necrolysis. The skin biopsy specimen, with histologic and direct immunofluorescence analysis, did not disclose any specific anomalies. After a period of clinical observation, intralesional injections of corticosteroids were decided and ulceration progressively decreased in 13 months. DISCUSSION: Complications of toxic epidermal necrolysis mainly occur at the acute phase. The most well documented sequelae are ophthalmological lesions. The most frequent cutaneous sequelae are cutaneous pigmentary changes and nail dystrophy. We report two observations of persistent mucous membrane erosions many months after the acute phase of toxic epidermal necrolysis. The pathophysiology of this complication, is rarely described and still remains unclear.

Aged↗
PubMedDate not supplied

MR imaging of the adrenal gland in Sipple disease.

We assessed imaging techniques [nuclear, CT, and magnetic resonance (MR)] in the diagnosis of pheochromocytomas in 10 patients with Sipple disease. Nine patients underwent surgery. Magnetic resonance detected all adrenal and ectopic lesions. Metaiodobenzylguanidine scans had two false-negative results. Computed tomography missed an ectopic lesion that was associated with bilateral medullar hypertrophy and had a false-positive result (a cortical nonhyperfunctioning adenoma). In our opinion MR may replace both CT and nuclear scans in the work up of Sipple disease.

3-Iodobenzylguanidine↗
PubMedDate not supplied

Orf and pregnancy.

A 31-year-old woman presented with orf on the forefingers at 34 weeks of gestation. The disease, contracted after handling sheep a week before, was uncomplicated, and the patient gave birth at term to a normal baby. Although some cases with features suggestive of viremic spread had been described, the authors find an overall benign picture of orf in man and recommend symptomatic therapeutic measures.

Adult↗
PubMedDate not supplied

[Transcutaneous absorption of ketoconazole in infant after application of Ketoderm].

The percutaneous absorption of ketoconazole was studied in 7 infants (1 to 5 month of age) with extensive seborrhoeic dermatitis (greater than 50% of the surface area), after application of a 2% ketoconazole cream (Ketoderm). The plasma concentrations of ketoconazole were measured by HPLC at the first, 5th and 10th day of the treatment. Despite the large surface involved, plasma levels ranging, from 0.018 to 0.133 micrograms/ml were measured. These values are low, as compared with the concentrations observed following oral administration (4 to 9 micrograms/ml), and suggest that the occurrence of systemic dose-dependent side effects is very unlikely. A careful monitoring of prescription remains however necessary.

Administration, Topical↗