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Biomedical subjects

A Svejgaard

Publications and source records attributed to A Svejgaard.

At least 307 records · Page 17Linked to original sources
PubMed1978

Lymphocyte transformation induced by nickel sulphate: an in vitro study of subjects with and without a positive nickel patch test.

Lymphocytes from 8 patients with contact dermatitis and a positive nickel patch test, 7 patients with contact dermatitis due to other factors and with a negative nickel patch test, and 9 other subjects, 7 of whom suffered from other dermatological disorders, were tested with the lymphocyte transformation test (LTT), using nickel sulphate in various concentrations. All execpt one of the nickel allergics showed a significant response to nickel, whereas the controls showed borderline (3 patients) or no response (12 patients). These observations confirm previous findings indicating that nickel hypersensitivity can be diagnosed in vitro. This may be of importance in cases of acute contact dermatitis where patch testing is undesirable. Some individuals with a negative nickel patch test responded significantly though weakly to nickel in the LTT, indicating that apart from acting as a specific antigen (hapten?) nickel sulphate may also have weak non-specific mitogenic properties.

Allergens↗
PubMed1978

Studies of HLA alloantigens of the Navajo Indians of North America. I. Variance of association between HLA-DRW (WIA) and HLA-DW specificities.

As a part of the 7th International Histocompatibility Workshop, 49 randomly selected Navajo Indians were B-cell (DR) typed. Thirty-three of these individuals were also HLA-D (L.D.) typed with the Caucasian derived Copenhagen homozygous testing cell panel. DRW 2, 7, and WIA 8 were clearly defined while DRW 3 and 4 were less well defined and DRW 1, 5, and 6 were not defined in this population by the Workshop antisera. There was highly significant correlation between DRW 7/DW 7 and WIA 8/DW 8 but no correlation at all between DRW 2/DW 2, DRW 3/DW 3 and DRW 4/DW4. These results, in part, were discordant with the finding of the 7th Workshop and suggest that either DRW (WIA) and DW alloantigens are the product of more than one gene locus or that these antigens are a product of one gene locus but that each antigen molecule has multiple factors.

B-Lymphocytes↗
PubMed1977

Reconstitution in severe combined immunodeficiency by transplantation of marrow from an unrelated donor.

A patient with severe combined immunodeficiency received seven transplants of bone marrow from an HLA-B-compatible and HLA-D-compatible unrelated donor in an attempt to provide immunologic reconstitution. The first four transplants achieved restricted engraftment with evidence of rudimentary immunologic function. A fifth transplant, given after low-dose cyclophosphamide, produced reconstituion of cell-mediated immunity. Marrow aplasia developed after recontamination with a nonpathogenic microflora. Transplantation of marrow previously stored in liquid nitrogen was ineffective. A subsequent transplant, administered after high-dose cyclophosphamide, achieved durable engraftment, with complete hematopoietic and immunologic reconstitution. Seventeen months after transplantation, full functional engraftment persists. Graft-versus-host disease has been chronic and moderately severe, but limited to the skin and oral mucosa. Transplantation of marrow from unrelated histocompatible donors may provide a useful treatment for patients with severe combined immunodeficiency or aplastic anemia who lack a matched sibling or related donor.

Bone Marrow Transplantation↗
PubMed1977

HLA and disease.

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Disease↗
PubMed1977

HLA antigens and manic-depressive disorders: further evidence of an association.

One hundred and seven unrelated Danish patients considered to be manic-depressive according to strict diagnostic, symptomatic and course criteria were typed for antigens of the HLA system, the major histocompatibility system in man. Preliminary results from the first 47 patients had previously been reported to suggest a positive association between manic-depressive disorders and HLA-A3, HLA-B7, and HLA-Bw16 and a negative association between such disorders and HLA-B8. Results from the extended series provide confirmatory evidence that there is a positive association between manic-depressive disorders and HLA-Bw16 and also strongly suggest a positive association between HLA-B7 and such disorders. HLA typing may prove to be a useful way of identifying sub-groups of manic-depressive patients for other biological studies. The associations described provide a potential lead for formulating hypotheses about the nature of the biological mechanisms which predispose to manic-depressive disorders.

Bipolar Disorder↗
PubMed1977

Lymphocyte chimerism after bone marrow transplantation. Surface markers and in vitro function of donor and recipient lymphocyte subpopulations.

Specific HLA antibodies were used to eliminate donor and recipient cells, respectively, from lymphocyte suspensions prepared from the blood of a child who had been transplanted with bone marrow from an HLA-A- and HLA-B-incompatible, HLA-D-compatible donor. About 70% of the lymphocytes were of donor HLA type, the remaining of recipient type. The phytohemagglutinin-responsive lymphocytes were exclusively limited to the lymphocyte population carrying donor-type HLA antigens. Membrane immunofluorescence investigations of the donor and recipient populations showed a low percentage of IgM-positive lymphocytes in the donor population and an extremely high proportion of IgM-positive lymphocytes in the recipient population. About 90% of the donor lymphocytes were T cells, as judged by their capacity to form rosettes between sheep erythrocytes and T lymphocytes; no cells in the recipient cell population expressed this ability.

B-Lymphocytes↗
PubMed1977

ABO blood groups in unipolar and bipolar manic-depressive patients.

The authors determined ABO blood groupings for 66 manic-depressive patients diagnosed and divided into bipolar and unipolar groups according to strict symptomatic and course criteria. A significantly higher percentage of bipolar patients than unipolar patients had blood group O, while a significantly higher percentage of unipolar patients than bipolar patients had blood group A. THese findings provide support for the validity of the unipolar-bipolar distinction and are consistent with the concept that vulnerability to manic-depressive disorders may be related to membrane disturbances.

ABO Blood-Group System↗
PubMed1977

Association between HLA-antigens and periodontal disease.

Patients with periodontitis juvenilis and patients with periodontitis were tissue typed. In the juvenile group, frequencies of tissue type specificities HLA-A9, HLA-A28, and HLA-BW15 were significantly increased as compared to the findings in the general population. In the periodontitis groups, no significant tissue type deviations were found.

Adolescent↗
PubMed1977

HLA antigens in Graves' disease.

HLA typing of 86 patients with Graves' disease was performed for the A, B, C and D series antigens. An increased frequency of HLA-B8 (47 per cent) and Dw3 (51 per cent) compared with controls (23.7 and 21 per cent, respectively) was observed. The increase of B8 and Dw3 was almost exclusively found in a group of 48 patients with relapse of disease, whereas the frequency of B8 and Dw3 in patients without relapse did not differ significantly from that of the control group. No association with the presence of exophthalmos, thyroid antibodies, or antibodies to Yersinia enterocolitica serotype 3 could be found.

Epitopes↗
PubMed1977

HLA and disease.

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B-Lymphocytes↗
PubMed1977

The HLA system.

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Denmark↗
PubMed1976

Interaction of HLA molecules with non-immunological ligands as an explanation of HLA and disease associations.

It is postulated that alloantigens (HLA in particular) may interfere with ligand/receptor interactions not directly involved in immune reactions. This interference may be regarded as a side-effect of the creation of new mutant HLA alleles which are maintained in the population for other reasons. As an example, it is suggested that some HLA molecules may have structures resembling those on receptors for certain hormones which could cause competition between HLA and receptor molecules for the hormone. Facilitation of ligand/receptor interaction may also be envisaged. Such interactions could under certain conditions lead to disease and might explain some associations between HLA and non-immunological diseases (e.g., manic-depressive disease and haemachromatosis).

Alleles↗
PubMed1976

Histocompatibility antigens and manic-depressive disorders.

Forty-seven unrelated Danish patients considered to be manic-depressive, according to strict diagnostic, symptomatic, and course criteria, were typed for histocompatibility (HLA) antigens. Significantly more manic-depressive patients than controls were found to have HLA-A3, HLA-B7, and HLA-Bw16, while significantly fewer manic depressives than controls had HLA-B8. All eight of the patients with HLA-Bw16 were bipolar patients, and none were unipolar depressive patients. We emphasize the need to consider the results with caution in view of the large number of antigens considered and the relatively small number of patients involved. When statistical corrections are made for the large number of antigens investigated, only the difference between bipolar patients and controls remains significant. The best way to determine if our findings are really significant is to attempt to confirm them in other series of patients. The importance of utilizing strict symptomatic and course criteria for the selection and polarization of proband is stressed.

Bipolar Disorder↗
PubMed1976

Transfer factor treatment of patients with multuple sclerosis. I. Preliminary report of changes in immunological parameters.

In five patients with definite multiple sclerosis and lack of cell-mediated immunity to measles and parainfluenza virus antigens, various immunological parameters were studied before and during transfer factor treatment. The study showed that cell-mediated immunity to measles virus antigen, as evaluated by the leukocyte migration agarose test, could temporarily be restored, using repeated injections of transfer factor pooled from unselected, normal blood donors.

Antibody Formation↗