Search PubMed⌕ Search

Biomedical subjects

A Sugar

Publications and source records attributed to A Sugar.

At least 109 records · Page 6Linked to original sources
PubMed1981

Peripheral corneal infiltrates in inflammatory bowel disease.

Two patients with ulcerative colitis and one patient with Crohn's disease developed unilateral corneal lesions. There were small white peripheral subepithelial infiltrates associated with mild irritative symptoms. No signs of staphylococcal infection were present, and the intestinal disease was inactive. The corneal lesions cleared rapidly with topical corticosteroids or systemic indomethacin.

Adult↗
PubMed1980

Penetrating keratoplasty in pseudophakic bullous keratopathy.

We studied 25 consecutive patients who underwent penetrating keratoplasty for pseudophakic bullous keratopathy. Follow-up time averaged 20 months. Ten patients required postimplantation surgical procedures because of complications after lens implantation. The time from lens implantation to onset of corneal edema averaged 18 months in patients without postimplantation surgical procedures and five months in patients with postimplantation procedures. The lens implants were removed in 11 patients at keratoplasty. Corneal clouding caused by graft rejection occurred in three patients, while 22 grafts remained clear. Final visual acuities were 6/6 (20/20) to 6/12 (20/40) in 13 patients, 6/15 (20/50) to 6/30 (20/100) in four patients, and 6/60 (20/200) or less in eight patients. We found no difference in final visual acuity between patients with lens implants removed at keratoplasty and those with lens implants left in place. Significant retinal pathology included cystoid macular edema, macular degeneration, and retinal detachment.

Aged↗
PubMed1980

Evaluation of 10-0 polyglycolic acid and polyglactin suture in rabbit limbal wounds.

Sutures of 10-0 polyglycolic acid (Dexon) or polyglactin (Vicryl) were used to close limbal incision in rabbits. When seven Dexon or Vicryl sutures were used alone wound disruption occurred in eight of twelve eyes. Sutures disappeared at 4-5 weeks. When three 10-0 nylon sutures were alternated with four 10-0 absorbable sutures, wound integrity was greatly improved. The handling properties of these sutures were excellent and inflammatory reactions were minimal. The 10-0 Dexon and Vicryl did not appear to differ in their properties, but they were insufficient for lasting would closure when used alone. It is suggested that these sutures not be used as the sole closure for limbal wounds.

Animals↗
PubMed1980

Evaluation of 9-0 polyglycolic acid and polyglactin suture in rabbit limbal wounds.

Sutures of 9-0 polyglycolic acid (Dexon) or polyglactin (Vicryl) were used to close limbal incision in rabbit eyes. The handling properties of both sutures were excellent and tissue reaction minimal. The majority of sutures disappeared four to six weeks postoperatively. Small areas of anterior wound gaping without leak occurred in half the eyes. While the performance of this suture was superior to that of 10-0 synthetic absorbables studied previously, it is advised that clinical application be approached with caution.

Animals↗
PubMed1979

The ocular manifestations and functional effects of occupational argyrosis.

Thirty employees of an industrial plant involved in the manufacture of silver nitrate and silver oxide underwent ophthalmologic evaluation in an effort to evaluate the frequency and extent of ocular argyrosis. The most frequently noted ocular abnormality was pigmentation of the conjunctiva, present in 20 workers; corneal pigmentation occurred in 15 workers. A direct relationship existed between the levels of pigmentation and duration of employment. Ocular pigmentation was seen more frequently than cutaneous pigmentation. Ten workers noted decreased night vision, but electrophysiologic and psychophysiologic studies of seven of these ten workers demonstrated no functional deficits.

Adult↗
PubMed1979

Time analysis of corneal endothelial cell density after cataract extraction.

Serial endothelial photographs were taken preoperatively and postoperatively in 200 eyes; 111 eyes contained a Rayner iris clip lens, 54 eyes contained a Fyodorov Sputnik lens, and 35 eyes had no lens. Central endothelial cell density was changed in all instances, with counts in implanted eyes declining 25 to 30%, and in nonimplanted eyes 10 to 15%. In both instances, the decline essentially ceased at about three months. The cause of the greater decline in implanted eyes appeared to be mechanical and subsequent cell loss after the 90-day period was virtually equal for the two groups. Methods that may be used to alter the difference in cell density occurring with implantation are best analyzed by using the 90-day period data for comparison.

Animals↗
PubMed1979

Binkhorst Lecture (Part 1). Experimental cataract surgery.

The use of intraocular lenses in cataract surgery leads to a greater corneal complication rate than surgical treatment without such devices. It has been assumed that the predominant reason for this is surgical trauma at the time of lens insertion. A laboratory study to verify and analyze this difference has been carried out, the cat being used as an experimental model. This first report evaluates the effect of the usual steps of cataract extraction on the density of corneal endothelial cells.

Animals↗
PubMed1977

Epithelial downgrowth following penetrating keratoplasty in the aphake.

Four of approximately 1,500 patients receiving corneal grafts developed epithelial downgrowth following penetrating keratoplasty. All were aphakic prior to grafting and had complicated postoperative courses. Epithelial proliferation over the iris and endothelium was demonstrated in three cases at the time of a repeat keratoplasty. While rare, this complication may occur more frequently than has been previously recognized.

Aged↗
PubMed1977

The phacoemulsification procedure. III. Corneal complications.

Persistent corneal edema is one of the complications of phacoemulsification. Five patients underwent this procedure 6 to 8 months before keratoplasty was performed. In addition to bullous keratopathy, two corneas had corneal scarring due to probe overheating or corneal vascularization of the anterior chamber. Electron microscopy of corneal specimens showed that four cases had Fuch's dystrophy without warts and one had guttata. Endothelial cell destruction varied from lessions of small size (15 to 50 mu) to large abrasions. Cases with severe edema and vitreous adhesion showed retrocorneal membrane formation. Surgical trauma seemed to have precipitated decompensation of these dystrophic corneas.

Aged↗
PubMed1976

The effect of splenectomy on corneal graft rejection.

Recent studies have suggested that the spleen may be essential for the "immunologic privilege" enjoyed by corneal grafts. We tested this hypothesis in rabbits by performing 38 exchange penetrating keratoplasties between 19 normal rabbits and 19 rabbits that had undergone splenectomy. No significant difference was found in the number of corneas rejected or the mean graft survival time between the normal and splenectomized rabbits.

Animals↗
PubMed1976

The phacoemulsification procedure. II. Corneal endothelial changes.

The effect of phacoemulsification, with the Cavitron-Kelman instrument, on the corneal endothelium of rabbit and cats was studied by scanning electron microscopy and nitroblue tetrazolium staining. The various steps of the procedure were examined separately. Irrigation of the anterior chamber of the eye with balanced salt solution (Plasma-Lyte) for ten minutes caused no cell damage. Ultrasound and irrigation alone for four to six minutes caused increased permeability to NBT. Edema of endothelial cells and cell junction disruption occurred after eight minutes of anterior chamber irrigation with Plasma-Lyte. Uncomplicated phacoemulsification produced moderate cellular edema with scattered loss of endothelial cells. Destruction of endothelial cells was frequent after phacoemulsification, it appeared to be due to lens nucleus manipulation in the anterior chamber, instrumentation, and needle contact. From two to five days postoperatively, intercellular edema, altered cell morphology, and mosaic pattern were seen. However, it gradually recovered and seven to ten days later the endothelium appeared normal.

Animals↗
PubMed1975

Comparison of in vitro corticosteroid response in pigmentary glaucoma and primary open-angle glaucoma.

We used an in vitro assay utilizing corticosteroids to inhibit transformation of peripheral blood lymphocytes to evaluate a group of 20 patients with pigmentary glaucoma. The pigmentary glaucoma patient group did not manifest the markedly increased cellular sensitivity to corticosteroids associated with primary open-angle glaucoma. If increased sensitivity to corticosteroids plays an essential role in the pathogenesis of primary open-angle glaucoma, then pigmentary glaucoma appears to be etiologically, as well as clinically, a separate entity.

Adult↗