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Biomedical subjects

A Steiner

Publications and source records attributed to A Steiner.

At least 199 records · Page 11Linked to original sources
PubMed1988

[Effect of propyphenazone on drug biotransformation in the liver. A comparison with phenylbutazone using the aminopyrine breath test].

By means of the aminopyrine breath analysis the influence of phenylbutazone, propyphenazone and of the combination preparation Wofapyrin "new" on the aminopyrine-N-demethylation, a hepatic microsomal performance of biotransformation in patients with diseases of the rheumatic circle of forms was examined. The enzyme-inducing effect of phenylbutazone known from literature could be confirmed. On the other hand despite a relatively highly dosed one-week treatment propyphenazone did not lead to changes of the demethylation capacity of the liver in the majority of the patients. In individual cases increases of the capacity are possible. In general, however, the doses of propyphenazone usual in the practice for the treatment of acute feverish infections no disturbing effects of induction or inhibition on the metabolic liver functions represented by the amino-N-demethylation are to be expected. The enzyme-inducing effect of Wofapyrin "new" is to be ascribed to the phenyl-butazone component.

Aged↗
PubMed1988

The phosphoinositide turnover of vascular smooth muscle cells is influenced by fish oil.

As the phosphoinositide cycle and high serum levels of low-density lipoprotein cholesterol may be involved in the pathogenesis of both hypertension and atherosclerosis, the effect of fish oil on low-density lipoprotein stimulation of phosphoinositide metabolism was studied in cultured rat vascular smooth muscle cells. Low-density lipoprotein-stimulated synthesis of inositol trisphosphate decreased to 5-48% of control values in vascular smooth muscle cells treated for 4 weeks with either fish oil or n-3 eicosapentaenoic acid (EPA), the active ingredient of fish oil. In addition, low-density lipoprotein-induced biosynthesis of thromboxane A2 was reduced by 50% in vascular smooth muscle cells precultured with either fish oil or EPA. Thus, our results may explain the mechanisms by which fish oil exerts its beneficial effects on both atherosclerosis and hypertension.

Animals↗
PubMed1988

Stimulation of the phosphoinositide signalling system as a possible mechanism for glucocorticoid action in blood pressure control.

Cortisol stimulates the phosphoinositide signalling system in smooth muscle cells of the rat aorta. After stimulation of the cells with cortisol, epinephrine or both compounds, inositol-1,4,5-trisphosphate concentrations were analysed by standardized ion-exchange chromatography procedure. A 15-min stimulation with physiological concentrations of cortisol (0.02-5.0 microgram/ml) led to a dose-dependent increase of the inositol trisphosphate concentrations (up to 500%) and also to a translocation of the calcium- and lipid-dependent protein kinase C activity from the cytosolic to the membranous compartment. Incubation of smooth muscle cells with epinephrine (10(-9) to -5 mol/l) did not lead to an increase in the inositol trisphosphate concentrations. However, after pre-incubation with an average dose of cortisol (0.2 microgram/ml) the inositol trisphosphate response was potentiated by 10(-7) mol/l epinephrine. Our results suggest that stimulation of the phosphoinositide system is a still unknown mechanism of glucocorticoid action in smooth muscle cells, which could influence intracellular free calcium and thus vascular reactivity and blood pressure.

Animals↗
PubMed1988

Do oral carotenoids protect human skin against ultraviolet erythema, psoralen phototoxicity, and ultraviolet-induced DNA damage?

This study was performed in order to (1) assess the magnitude of a possible protective effect of oral carotenoids on ultraviolet B (UVB)-, ultraviolet A (UVA)-, and psoralen ultraviolet A (PUVA)-induced erythema in human skin and (2) to evaluate whether the postulated prevention of skin cancer by prophylactic administration of carotenoids is based on a decrease in UVB-induced DNA damage. Twenty-three healthy volunteers received oral carotenoids (150 mg/day) for 4 weeks. Serum levels were quantitated, and ranged from 390 to 1710 micrograms/dl. Before and after carotenoid administration, the UVA- and UVB-MEDs and the PUVA-MPD were determined by standard phototesting. DNA damage was assessed by autoradiographical measurement of unscheduled DNA synthesis (UDS) following UVB exposure before and after treatment. No statistically significant carotenoid-dependent protection was found against UVA, UVB, and PUVA erythema by comparing the pre- and postcarotenoid erythema doses. Also at the DNA level there was no indication of a protective effect that could be detected with the methods employed: the amount of UVB-induced UDS was not decreased after carotenoid treatment. We conclude that (1) carotenoids do not reduce UVB-, UVA-, or PUVA-induced erythema in human skin; that (2) reactive oxygen species may not be involved in PUVA-erythema production or, alternatively, carotenoids may not quench these radicals sufficiently in vivo; and that (3) carotenoid protection against UVB-induced carcinogenesis does not operate by reducing the number of mutagenic lesions in DNA.

Administration, Oral↗
PubMed1988

Recombinant gamma interferon and in vivo induction of HLA-DR antigens.

Recombinant human IFN-gamma, used for treatment of melanoma and renal carcinoma, was found to induce HLA-DR expression on human keratinocytes in vivo. HLA-DR antigens bound to keratinocytes of the basal and suprabasal layers of the epidermis were observed after intramuscular or intravenous injections of 0.5 mg/kg body weight IFN-gamma, 3 times a week. Keratinocyte-bound HLA-DR antigens were first observed at the beginning of the third or fourth week of treatment, but HLA-DQ and HLA-DP antigens were never detected on keratinocytes. The intracytoplasmic constant (gamma) chain of the class II molecules was also not detectable within the keratinocytes. Patients who received IFN-alpha 2 therapy, did not exhibit keratinocyte-bound HLA-DR antigens.

Female↗
PubMed1988

Liver involvement in human schistosomiasis mansoni. Regression of immunological and biochemical disease markers after specific treatment.

Peripheral blood cholyglycine and procollagen-III-peptide were measured in 22 Zairean patients with hepatomegaly caused by S. mansoni before and after treatment with praziquantel. Circulating T-cell subsets and cutaneous in vivo delayed type hypersensitivity were assessed; serum neopterin and beta 2-microglobulin served as indicators for macrophage/lymphocyte activation. The results were compared to age and sex matched patients with S. mansoni infection limited to the intestinal tract and schistosomiasis free controls with equal socioeconomic background. Abnormal serum cholyglycine and neopterin levels and alterations of circulating T-cell subset frequencies were associated with hepatomegaly in schistosomiasis. Normalization of these parameters reflected a regression of egg-induced immunopathology as early as two months after specific chemotherapy. Serum procollagen-III-peptide concentrations rose significantly after treatment, suggesting release of propeptide previously incorporated without cleavage into tissue collagen. The combination of these biochemical and immunological parameters may allow assessment of the pathophysiological mechanisms responsible for liver disease in individual patients.

Adolescent↗
PubMed1988

Verrucous malignant melanoma.

Five cases of verrucous malignant melanoma--a rare variant of melanoma that was described in 1967, but is rarely mentioned today--are presented and the clinical and histopathologic criteria defining this variant are discussed. The importance of this rare entity in the differential diagnosis of verrucous pigmented skin lesions is emphasized.

Adult↗
PubMed1988

[Urachal abscess without pathologic changes in the extra-abdominal navel in a cow. Case report].

A rarely diagnosed case of urachal abscessation without any signs of inflammation of the extra-abdominal navel in a seven-month-old Braunvieh heifer is described. The symptoms of this disease, its diagnosis by the means of ultrasonographic examination and its therapy are explained. The technique of ultrasonographic examination is supposed to be a facilitation of presurgical diagnosis of umbilical disease. Nevertheless the value of this diagnostic procedure should be checked up on more patients.

Abscess↗