Search PubMed⌕ Search

Biomedical subjects

A Steg

Publications and source records attributed to A Steg.

At least 91 records · Page 5Linked to original sources
PubMed1988

[Tissue effects of pulsed-dye laser lithotripsy. Experimental study on the ureter in dogs].

The tissue effects of pulsed dye laser (Pulsolith) were studied in 10 dog ureters. The results show the absence of ureteric perforation or damage to adjacent organs by the laser irradiation. The only lesions observed were focal hyperplasia of the urothelium and chorion with extremely limited abrasions of the urothelium. The absence of tissue damage of the pulsed dye laser allows it to be used in human clinical practice.

Abdominal Muscles↗
PubMed1988

[Treatment in a ventral position of vesicovaginal fistula by ordinary suture or autoplasty of the labia majora].

The authors describe a modification of technique which improves the exposure of vesico-vaginal fistulas treated surgically by a low approach. The patient is placed in a ventral horizontal position with the thighs in abduction, and the buttocks spread apart. With the patient installed in this way, care is facilitated by more anatomical technique. Using this installation it is possible to close the fistula by simple suture (Chassar-Moir) or with interposition of the labium majus (Martius autoplasty).

Female↗
PubMed1988

Hormonal consequences of orchidectomy for carcinoma of the prostate. With special reference to the measurement of free testosterone in saliva and prostatic dihydrotestosterone levels.

22 patients with metastatic carcinoma of the prostate were treated by subcapsular orchidectomy and followed by regular determinations of plasma testosterone, dihydrotestosterone, delta 4-androstenedione, dehydroepiandrosterone sulfate and testosterone estradiol-binding globulin as well as salivary testosterone, which reflects free plasma testosterone. Subcapsular orchidectomy constantly induced a dramatic and stable decrease in testicular androgens without modification of adrenal androgens or testosterone estradiol-binding globulin. Free testosterone levels vary widely for a given value of plasma testosterone, probably due to individual variations of testosterone estradiol-binding globulin. Salivary testosterone is preferable to plasma testosterone for monitoring hormonal therapy for metastatic carcinoma of the prostate. In another group of orchidectomized stage-D2 patients, obstructive symptoms motivated transurethral resection of the prostate allowing the assay of intraprostatic dihydrotestosterone which was constantly below the dihydrotestosterone level of androgen-independent tissues (below 2.5 ng/g).

Aged↗
PubMed1988

[Extracorporeal lithotripsy as the primary procedure in the treatment of large kidney calculi].

Extracorporeal shock wave lithotripsy (ESWL) as primary treatment for large renal stones has been evaluated in this clinical study of 55 patients. Patients were treated using the Dornier HM-3 lithotripter. Twenty-one (38%) patients presented with a stone burden greater than 4 centimeters. Nineteen patients had "steinstrasse", of which 8 had to undergo a secondary procedure. Sixteen (29%) patients had no residual stone, 5 had clinically non significant stones and 34 had clinically significant stones. Out of the 15 patients who underwent a second ESWL, only 2 were rendered stone-free. In this study, ESWL was not found to be a satisfactory treatment for large renal stones.

Endoscopy↗
PubMed1987

Evaluation of diagnostic criteria for Leydig cell tumours in adult men revealed by gynaecomastia.

Gynaecomastia caused by Leydig cell tumours (LCT) in adult men may appear a long time before clinical evidence of testicular swelling. To evaluate the diagnostic criteria for LCT, hormonal status was studied in 14 cases and compared with results of a control group (CG) and 10 men with idiopathic gynaecomastia (IG). The mean plasma T level was significantly (P less than 0.005) lower in LCT (16.7 +/- 1.7 SEM nmol/l) than in CG (23.0 +/- 1.3 nmol/l). However, individual plasma T levels were in the normal range in 9/14 LCT. The mean plasma E2 level was significantly (P less than 0.001) higher in LCT (204.9 +/- 27.6 pmol/l) than in CG (87.9 +/- 7.7 pmol/l). However, individual plasma E2 levels were in the normal range in 5/14 LCT. In LCT, neither means of basal gonadotrophin levels nor the gonadotrophin responses to LHRH were different from CG. The mean of the plasma T responses to hCG did not differ between LTC, CG and IG. However the mean of E2 peak responses appeared significantly (P less than 0.005) higher in LCT (735.3 +/- 103.4 pmol/l) than in CG (420.5 +/- 40.4 pmol/l). The mean of the E2 peak responses was significantly (P less than 0.001) lower in IG (196.5 +/- 33.4 pmol/l) than in CG. Likewise the mean of plasma E2 levels, measured on day three following hCG administration, remained significantly (P less than 0.001) higher in LCT (662 +/- 94 pmol/l) than either in CG (228 +/- 14 pmol/l) or in IG (158 +/- 25 pmol/l). On day 3 following hCG administration, there was no overlap in individual plasma E2 levels between either LCT and CG or LCT and IG. In all LCT, plasma beta-hCG levels were in the normal range. A testicular echogram, performed in 12 LCT, confirmed the presence of a palpable tumour in 10 and revealed an occult tumour in two cases. We conclude that normal plasma beta-hCG levels, a prolonged plasma E2 response to hCG and testicular echogram appear to be the best criteria for early diagnosis of LCT responsible for gynaecomastia in adult men.

Adult↗
PubMed1987

[Risk of infection in biopsy of the prostate].

In order to more clearly define the risk of infection of prostatic biopsy, the authors conducted an analysis of the morbidity of each method. The risk of infection, the possible forms of prophylaxis and the best indications are presented for each method.

Biopsy↗
PubMed1987

[Bilateral kidney cancer in a patient with Von Hippel-Lindau disease].

A case of bilateral renal carcinoma in a female patient presenting with Von-Hippel-Lindau disease is reported. Many different lesions may be associated in this autosomal dominant disease and the presence of renal involvement must be investigated in every patient. Renal carcinoma, often bilateral, is now frequently treated by conservative methods. It is always necessary to conduct an epidemiological survey in the entire family.

Angiomatosis↗
PubMed1987

[Treatment of vesicovaginal fistulas by ventral approach. Apropos of 10 cases].

An improved technic for exposure of urethrovesicovaginal fistula during operation by a low approach involves placing the patient in ventral decubitus with the thighs abducted and the buttocks separated. Successful results have been obtained in 7 of the 10 patients operated upon during the last two years. One of the 3 patients treated unsuccessfully had recovery surgery with a positive outcome, the 2 others presenting pronounced breaking down of urethra.

Adult↗
PubMed1987

[Cystine calculi. In vitro solubility and chemical structure].

A series of cystine stones extracted from the same subject by pyelotomy was used to study the in vitro solubility of these stones in various solutions. Isotonic bicarbonated saline presented a definite dissolving action, but the stone dissolved relatively slowly alpha-mercapto-propionyl-glycine was much more active, even when mixed urine. N-acetylcystine had the same degree of effectiveness as alpha-mercapto-propionyl-glycine. One stone in this series, which was partially covered by a coating of calcium phosphate, dissolved much more slowly than the other stones. In subjects with cystine stones, longstanding large stones are frequently mixtures of phosphates and cystine and, in 21 cases, chemical analyses and infra-red spectrography demonstrated the presence of calcium phosphate on the surface or in the inferior of these stones, associated with ammoniaco-magnesium phosphate in three cases. The presence of phosphates makes oral medical treatment ineffective, but mixed stones are more friable than pure cystine stones and are therefore easier to treat by extracorporeal lithotripsy.

Chemical Phenomena↗
PubMed1987

Hormonal consequences of orchidectomy for carcinoma of the prostate. With special reference to the measurement of free testosterone in the saliva.

22 patients with metastatic carcinoma of the prostate were treated by subcapsular orchidectomy and followed by regular determinations of plasma T, DHT, D4A Dione, SDHEA, and TeBG as well as salivary T which measures the free Testosterone. Subcapsular orchidectomy constantly induced a dramatic and stable decrease of testicular androgens or TeBG. Free Testosterone levels vary widely for a given value of plasma T, probably due to individual variations of TeBG. Therefore salivary T should be used preferably to plasma T to monitor hormonal therapy of metastatic carcinoma of the prostate.

Aged↗
PubMed1987

[Epidermoid carcinoma of the bladder. Apropos of 46 cases].

In order to define the prognosis of pure squamous carcinomas of the bladder, on the one hand (group I), and the possible aggravating role of the presence of squamous tissue in an invasive renal cell tumour, on the other hand (group II), 46 cases files of patients treated between 1975 and 1984 were analysed retrospectively. Group I consisted of 18 cases of pure squamous carcinoma (11 men with a mean age of 71 years and 7 women with a mean age of 74 years). 66% of cases presented with haematuria, but urinary cytology was of little help. The diagnosis was established by transurethral resection with 18 grade 3 tumours: stage A in 4 cases and stage B in 14 cases. 10 patients had unilateral (8 cases) or bilateral (2 cases) complications of the upper urinary tract. The presence of lymph node and/or haematogenous metastases was investigated by bone scan, hepatic ultrasonography, pulmonary tomography and, most importantly, by bipedal lymphography combined with percutaneous cyto-aspiration of suspicious nodes. 4 patients presented with invasion of the obturator lymph nodes (2 cases) and iliac lymph nodes (2 cases). 9 patients were treated by total cysto-prostatectomy, 6 patients by radiotherapy (60 Grays) and 3 patients did not receive any treatment. The overall survival was 12.5% after 2 years. None of the patients treated by radiotherapy were alive after 2 years. 29% of the patients treated by surgery survived for 2 years, but none of them were alive after 5 years, essentially as a result of local recurrence.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1987

[Infiltrating cancer of the bladder with lymph node invasion: is total cystectomy justified?].

In order to assess the potential benefits of radical cystectomy in bladder cancer associated with pelvic lymph node metastasis, a retrospective study compared 2 groups of patients with T2-T3 N+ bladder cancer: 10 treated by radical cystectomy and 14 treated conservatively once the diagnosis of nodal metastasis had been established by fine needle node aspiration or lymphadenectomy. The survival rates were identical in both groups: 80% of the patients died within 2 years, 60% during the first year after diagnosis, mainly due to distant metastasis. No patient in the conservative arm required salvage cystectomy because of local progression. It is concluded that radical cystectomy is of little benefit in T2-T3 N+ bladder cancer, a disease which is no longer amenable to purely local treatment.

Aged↗
PubMed1986

Cyproterone acetate lead-in prevents initial rise of serum testosterone induced by luteinizing hormone-releasing hormone analogs in the treatment of metastatic carcinoma of the prostate.

Luteinizing hormone-releasing hormone (LH-RH) analogs are an effective treatment of metastatic carcinoma of the prostate. However, they induce an initial rise in serum testosterone responsible for 10-30% of diseases flares. The efficacy of the antiandrogen cyproterone acetate (CPA) was tested in 15 patients with metastatic carcinoma of the prostate. 10 patients were given 100 mg CPA t.i.d. from day 1 to 14 in association with the LH-RH analog Buserelin, 500 micrograms t.i.d., from day 7 to 14.5 patients were given CPA and Buserelin at the same doses from day 1 to 7. Serum testosterone determinations were obtained on days 1-7, 8, 11 and 14, at 08.00 h, and on days 8, 11, 1 h after each analog injection in group 1, and on days 1, 4 and 7 at 08.00 h and 1 h after each analog injection in group 2. All the patients were then treated by orchidectomy. Pretreatment with CPA blunted the initial rise of testosterone which never rose above pretreatment levels. Simultaneous treatment had no demonstrable effects on the rise of serum testosterone. It is concluded that pretreatment with CPA allows a safer use of LH-RH analogs in the treatment of metastatic carcinoma of the prostate.

Aged↗