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Biomedical subjects

A Steg

Publications and source records attributed to A Steg.

At least 73 records · Page 4Linked to original sources
PubMed1989

[Pulsed lasers in the treatment of urinary calculi].

Intracorporeal lithotripsy of urinary calculi by pulsed dye laser recently enriched the urologist's therapeutic arsenal. We recall the in vitro studies and animal experimentations which demonstrated the feasibility of laser lithotripsy and the absence of harmful tissue damage. The ideal indications for intracorporeal lithotripsy are ureteral stones accessible by rigid and, more especially, flexible ureteroscopy. The results of the first published series using this technique are very encouraging.

Animals↗
PubMed1989

[Endocorporeal lithotripsy using a pulsed laser].

Intracorporeal lithotripsy of urinary calculi by pulsed dye laser has recently enriched the urologist's therapeutic arsenal. We recall the in vitro studies and animal experimentations which demonstrated the feasibility of laser lithotripsy and the absence of harmful tissue damage. The ideal indications for intracorporeal lithotripsy are ureteral stones accessible by rigid and, more especially, flexible ureteroscopy. The results of the first published series using this technique are very encouraging.

Humans↗
PubMed1989

[Antilithogenic action of dehydroxymaleic, ketomalonic (mesoxalic) and tartronic acids in relation to experimental lithiasis in rats].

The authors study the effects of three acids, one with four carbon atoms, dihydroxymaleic acid, the two others with three carbon considered atoms, ketomalonic acid and tartronic acid. A first study considered the effects of these products on experimental lithiasis induced by oxalic acid, glyoxylic acid and ethylene-glycol. Dihydroxymaleic acid. Monohydrate calcium oxalate stones can be easily induced in the male rat, with in 24 hours, by an intraperitoneal injection of oxalic acid, at the rate of 8 mg per 100 g of body weight. If 25 mg of dihydroxymaleic acid are injected simultaneously via the intraperitoneal route, to a rat weighing 150 g, the lithiasis observed after 24 hours is just as severe. Experimental monohydrate calcium oxalate lithiasis is also induced by intraperitoneal injection of 8 to 9 mg of glyoxylic acid in a 100 mg rat. Dihydroxymaleic acid, injected at the same time as glyoxylic acid, also via the intraperitoneal route, at the rate of 50 mg for a rat weighing 150 g, results in total suppression of the lithiasis. Dihydroxymaleic acid also prevents lithiasis induced by the absorption by the rat, for several weeks, of a 1% ethylene-glycol solution if it is mixed to this solution at the rate of 5 mg per ml. A 12% ethylene-glycol solution given to the rat at the rate of 0.55 ml for 100 g of body weight induces the next day a comatose state and a diffuse parenchymatous monohydrate calcium oxalate lithiasis: coma and lithiasis are prevented by the simultaneous absorption of dihydroxymaleic acid at the rate of 65 to 70 mg. The ketomalonic acid.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1989

[A case of a large pyelic calculus composed only of ammonium urate].

The authors report a case of pure ammonium urate stone. It was a very large lightly radiopaque pelvic stone, which was extracted by pyelotomy and analysed by infra-red spectrography. The clinical history did not reveal a long history of chronic infections. The stone was diagnosed by urography performed after an acute urinary trad infection. Proteus mirabilis was found at one time, but only after the surgical operation. The blood and urinary laboratory check-up was normal. No case of such a large pure ammonium urate stone especially in adults, can be found in the literature. The pathogenesis is not obvious, and could not be explained without an abnormal urinary ammonia production during the development of the stone, but the lack of associated phosphate precipitation cannot be explained.

Adult↗
PubMed1989

[Rigid and flexible ureteroscopy. Apropos of 200 consecutive cases].

191 patients underwent a total of 200 ureteroscopies. Indications for these were as follows: ureter stones (172 cases); ureteral anomalies undiagnosed by other methods (20 cases); therapeutic ureteroscopy (8 cases). Stones: ureteroscopy for stones was carried out using either a rigid instrument (156 cases) or a flexible ureteroscope (16 cases). The localization of the stones was pelvic (123 cases), iliac (18 cases) or lumbar (10 cases). The stones were either removed directly using the basket under visual control (74/139 cases), or removed by ultrasonic/laser fragmentation (65/139 cases). As regards the rigid ureteroscope, success rates were 89% (139/156); 15 patients required additional therapy. Repeated ureteroscopic interventions always provided positive results. As concerns flexible ureteroscopy, we only had one positive result; 15 failure cases warranted repeated additional treatments. In three instances, failure with flexible ureteroscopy was corrected by using the rigid device during the same surgical period. We observed a single case of major complication in this series, i.e., a laterovesical urinoma which necessitated surgical drainage and was linked to the lack of ureteral drainage following ureteroscopy. Diagnostic ureteroscopic examinations: in 20 instances, ureteroscopy allowed to diagnose with precision the ureteral abnormality. No complication was reported following diagnostic ureteroscopy. Therapeutic ureteroscopy: such interventions were carried out to introduce a guide into the renal cavities (3 cases); to remove a double J stent, the lower extremity of which had moved up into the ureter (3 cases); or to carry out endoscopic ureterotomy (2 cases). Ureteroscopy is a safe and reliable method for the treatment of ureteral stones, and more particularly of stones localized in the distal part of the ureter.(ABSTRACT TRUNCATED AT 250 WORDS)

Cystoscopes↗
PubMed1989

Systemic bacillus Calmette-Guerin infection in patients treated by intravesical BCG therapy for superficial bladder cancer.

Among 169 patients treated for superficial bladder tumors with intravesical instillations of 150 mg BCG-Pasteur, five developed BCG-itis--a severe systemic infection with bronchopulmonary lesions and granulomatous hepatitis. In four cases, the complication appeared early during treatment (after three, six, six and eight instillations respectively). In one case, BCG-itis appeared 6 months after completion of 2 years monthly maintenance therapy. In addition to pulmonary basal infiltration and granulomatous hepatitis, intramedullary granulomatosis was observed. In three patients, the role of trauma has to be considered, as BCG-itis appeared after a traumatic instillation with bleeding. All patients were cured by combined treatment with Rifampicin, Isoniazid and Prednisolone.

Administration, Intravesical↗
PubMed1989

[Infiltrating tumors of the bladder. Local response to systemic platinum-based chemotherapy].

16 patients with invasive bladder cancer were treated primarily "bladder in place", with chemotherapy. (M-VAC, CDDP + MTX). There were 11 with T1 to T4, N+, M0, M+, 5 with T1, T2, N0, M0. The aim of the study was to evaluate the response of bladder lesions to chemotherapy. 2 had complete response (CR), 6 partial response (PR) and 8 no-response (NR). Patients with complete responses and partial responses were found to have complete resection before chemotherapy. Unresectable lesions were associated with NR patients. The results did not show a significant improvement and they question the role of neo-adjuvant chemotherapy.

Aged↗
PubMed1989

[Detection of a prostatic adenocarcinoma in the cysto-prostatectomy specimens of an invasive tumor of the bladder].

Among one hundred consecutive patients submitted to radical cysto-prostatectomy for invasive transitional cell carcinoma of the bladder, 26 also exhibited adenocarcinoma of the prostate on histological specimens: 17 microscopic foci and 9 larger prostate carcinomas. In 3 cases, the tumor was found in the apex of the prostate gland. Pelvic lymphadenectomy was positive in 4 cases but always corresponded to a urothelial metastasis. Follow-up was never marked by a metastatic development of this adenocarcinoma. This frequency of latent prostatic adenocarcinoma is not different from its observed incidence in the general population on autopsy studies. The high incidence of this association makes removal of the whole prostatic tissue during total cystectomy necessary.

Adenocarcinoma↗
PubMed1989

[Urogenital tumors and HIV-1 infection].

Four patients with solid genito-urinary tumors and HIV 1 infection have been treated in our institution over the last 2 years, including 2 with seminoma, 1 with renal adenocarcinoma and 1 with renal angiosarcoma. All had severely impaired immunity with a low CD4 level. Three had or developed a true AIDS syndrome according to the WHO and CDC criteria (1988). The remaining patient was seropositive and died less than 3 months following the diagnosis of renal angiosarcoma, he is the first reported case of renal sarcoma in a patient infected with HIV 1. Two patients were homosexuals and the other 2 were drug addicts. Along with other reported cases, our cases may underline the association between depression of immunity due to HIV and onset of solid genito-urinary tumors.

Acquired Immunodeficiency Syndrome↗
PubMed1989

Bladder tumors invading the lamina propria (stage T1): influence of endovesical BCG therapy on recurrence and progression.

We treated 47 patients with transitional cell bladder carcinoma invading the lamina propria (stage T1) from 1984 to 1986 with complete transurethral resection followed by one to three courses of endovesical BCG instillation and followed them for 14-64 months with cystoscopic and endoscopic tests and bladder biopsy. Complete response was achieved in 64%, and 36% had recurrences (recurrence rate per 100 month/patient, 2.2); 21% progressed to muscle invasion. Duration of treatment, tumor size or type (solid versus papillary), and presence of carcinoma in situ bore no relation to the final result. A history of previous T1 bladder tumor appeared associated with a higher risk of progression, although not statistically significantly. The results were compared with those obtained by transurethral resection alone in a similar group of 50 patients treated from 1982 to 1984 and followed for 12 to 100 months. Of these 90%, had recurrence, and 34% progressed to muscle invasion, with a recurrence rate per 100 month/patient of, 9.2. In light of the limits of a non-randomized historical comparison, it appears that endovesical BCG therapy favorably alters the recurrence pattern of T1 bladder cancer.

Administration, Intravesical↗
PubMed1988

[Renal angiomyolipoma. Diagnostic value of magnetic resonance imaging].

Owing to the wider use of ultrasonography, renal angiomyolipoma is now diagnosed with increasing frequency. Within a few months, 10 female patients were explored by ultrasounds, computerized tomography and nuclear magnetic resonance (Magniscan 5,000, 0.5 Tesla). At ultrasonography the lesion was hyperechogenic in 9 cases and heterogenic in 1 case. At computerized tomography 7 patients had a strongly hypodense lesion and 3 had a lesion of slightly positive density. At magnetic resonance imaging the lesion produced a characteristically loud signal similar to that of fatty tissues. In practice, ultrasonography and computerized tomography combined provide the diagnosis in most cases. In case of doubt, especially since the tumour may be small and asymptomatic and the lesions multiple and/or bilateral, magnetic resonance imaging with its fat-like loud signal confirms the diagnosis and leads to partial resection. When no complications are present, it may even suggest that surgery is unnecessary.

Female↗
PubMed1988

[Sexual disorders after an operation for benign prostatic hypertrophy].

A prospective study was conducted on the sexual function of 70 patients undergoing transurethral (48 cases) or transvesical (22 cases) prostatectomy for benign prostatic hypertrophy. 22 patients with no sexual activity before operation, remained sexually inactive after surgery. Frequency of intercourse and penile erection remained generally unchanged after operation. Retrograde ejaculation was observed in 33 patients (69%). Only one patient complained of total loss of potency after operation. Orgasm was maintained in all other patients; however 25 patients considered it to be "different". 4 of the sexually active operated patients (8%) and 7 of their partners complained of lack of sexual satisfaction after operation.

Aged↗
PubMed1988

Effects of pulsed dye laser lithotripsy on tissues. Experimental study in the canine ureter.

This experimental study demonstrates the absence of irreversible tissue damage after lithotripsy with a pulsed dye laser. The absence of thermal damage with this laser is due to the beam divergence capacity at the end of the fiber and to the short pulse, which generates very low thermal effect. These results as a whole confirm the safety of the pulsed dye laser and indicate that it can be used for clinical treatments in humans.

Animals↗