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Biomedical subjects

A Solomon

Publications and source records attributed to A Solomon.

394 records · Page 22Linked to original sources
PubMedDate not supplied

Retinitis pigmentosa, Coats disease and uveitis.

PURPOSE: To study the anamnestic immune response to retinal specific antigens of two patients suffering from a rare triad of retinitis pigmentosa, Coats disease and uveitis. PATIENTS: 17-year-old girl presented with an acute episode of panuveitis, and her 19-year-old brother suffered from chronic uveitis. On examination, both patients showed retinal vascular changes and subretinal exudations typical of Coats disease, with bone-spicule pigmentary changes as observed in retinitis pigmentosa. RESULTS: All routine examinations were unrevealing. However, the peripheral lymphocytes from these two siblings gave a specific anamnestic response to retinal antigens in vitro. A stimulation index of 4.6 was obtained when the sister's lymphocytes were stimulated with interphotoreceptor binding protein, IRBP--during the acute stage of the uveitis. The brother's lymphocytes showed a stimulation index of 2.7 towards S-Ag during the chronic phase of his uveitic condition. CONCLUSIONS: These results indicate that autoimmunity towards retinal antigens may play some role in specific types of retinitis pigmentosa. Whether these autoimmune reactions are a primary pathological mechanism or are secondary to the extensive destruction of the photoreceptor layer resulting from the retinitis pigmentosa remains debatable.

Adolescent↗
PubMedDate not supplied

Silicosis and tuberculosis: Part 2--a radiographic presentation of nodular tuberculosis and silicosis.

Indolent nodular pulmonary tuberculosis (TB) in workers exposed to silica dust may go undetected clinically and radiographically, especially in the absence of identification of tubercle bacilli in sputum. Illustrative cases demonstrating the radiographic manifestations of coexistent pulmonary silicosis and the indolent form of nodular TB are presented. Alterations in the usual chronologic progress, a rapid advance in nodular profusion or size outside the expected time frame, and distinct pattern alterations are features indicating the presence of TB associated with silicosis.

Environmental Exposure↗
PubMedDate not supplied

Silicosis and tuberculosis: a proposed radiographic classification of tuberculosis to accompany the ILO international classification of radiographs of pneumoconioses.

A significant proportion of workers exposed to silica dust are at risk of developing tuberculosis (TB). The higher the International Labor Organization (ILO) category of silicosis, the greater the TB risk. Subtle radiographic presentations of TB may be the initial manifestation of TB, particularly in the absence of sputum identification of TB bacilli. A proposed TB x-ray-reading form in addition to the ILO categorization of silicosis is offered. The implementation of a standardized TB x-ray-reading approach should alert the clinician to indolent TB lesions.

Disease Notification↗
PubMedDate not supplied

Self-contained tubular drill guard for anterior cervical fusion.

A self-contained tubular drill guard was adapted for use in performing anterior cervical discectomies and interbody fusions. The use of this instrument eliminates steps, provides absolute safety against drilling too deeply, allows for adjustment in individual cases, provides for easy inspection of the trephine hole, permits electing the cephalocaudal angle of the drill, and gives a measurement of the ultimate depth of the trephine hole. In 171 consecutive operations only one neurological complication occurred, and total morbidity related to cervical surgery was 6% (7% morbidity was associated with surgery at the donor site). The data suggest that the technical modification herein advocated reduces the surgical complication rate.

Cervical Vertebrae↗
PubMedDate not supplied

Relaxing incision guided by videokeratography for astigmatism after keratoplasty for keratoconus.

PURPOSE: To evaluate the efficacy of topographic measurements for relaxing incisions in astigmatism following penetrating keratoplasty for keratoconus. METHODS: Twenty patients (20 eyes) had relaxing incisions between July 1989 and August 1994 for high astigmatism after penetrating keratoplasty for keratoconus. Ten eyes were evaluated using a HaagStreit keratometer (1989-1991) and 10 eyes were evaluated using EyeSys videokeratography (1991-1994). Relaxing incisions were performed at the steep meridians in the donor/host wound. RESULTS: Mean preoperative astigmatism was 7.75 +/- 2.05 D (range, 4.50 to 12.00 D) for the keratometry group, and 6.49 +/- 3.24 D (range, 1.11 to 10.13 D) for the videokeratography group. Mean astigmatism following relaxing incision was 3.90 +/- 2.02 D (range, 0.93 to 6.50 D) for the keratometry group and 3.06 +/- 1.62 D (range, 0.07 to 5.64 D) for the videokeratography group (no significant difference). Vector analysis revealed a vectorial change of 4.64 +/- 2.54 D for the keratometry group and 4.68 +/- 2.08 D for the videokeratography group (no significant difference). Mean spectacle-corrected visual acuity was significantly improved in the topography-guided group following the procedure (P = .021). Complications included perforations in 3 of 20 eyes. Four patients (4 eyes) in the keratometry group and one patient (1 eye) in the videokeratography group had residual astigmatism greater than 5.00 D. Four patients in the keratometry group needed a second procedure of relaxing incision because of irregular (2 eyes) or high (2 eyes) astigmatism. One patient (1 eye) in the videokeratography group needed a second relaxing incision. CONCLUSIONS: Videokeratography as a guide for relaxing incision has some benefits over standard keratometry. Preoperative evaluation with videokeratography did not significantly improve the postoperative astigmatism. Fewer reoperations were needed when videokeratography was used.

Adolescent↗
PubMedDate not supplied

Corneal dynamics after single interrupted suture removal following penetrating keratoplasty.

PURPOSE: To evaluate corneal topographic changes after removal of a single interrupted suture in patients who underwent keratoplasty for keratoconus. METHODS: Fifteen interrupted sutures in 15 eyes after keratoplasty were removed to control astigmatism in a prospective clinical study. Videokeratography using an EyeSys Corneal Analysis System was performed before suture removal, and 1 hour, 1 day, 1 week, and 2 to 4 weeks after suture removal. Changes in dioptric power and axis of the steepest and flattest semimeridians were evaluated. RESULTS: The range of the dioptric change of the steepest semimeridian was from -0.43+/-0.34 D during the first hour to +0.70+/-0.39 D from 1 day to 1 week. The largest axis change of the steepest semimeridian (17.1 degrees+/-5.6 degrees, range 1 degree to 66 degrees ) occurred during the first hour (P = .006). The largest surgically induced vectorial change occurred during the first hour (16.10 @ 10.5 ), while relative stability of the steepest semimeridian was observed during the rest of the study period. Changes in power and axis of the flattest semimeridian were also demonstrated. A variety of topographic corneal patterns were demonstrated following suture removal, indicating unpredictable change of astigmatism. CONCLUSIONS: The steepest semimeridian of the central 3-mm zone showed maximal vectorial change 1 hour following suture removal. Reciprocal changes occurred at the same time in the flattest semimeridian. The response of the corneal surface to suture removal is unpredictable and complex.

Adult↗
PubMedDate not supplied

Time course of electroretinographic recovery following argon laser photocoagulation in cats.

We wished to study in detail the time course of changes in the electroretinogram (ERG) that occur following lesioning of the cat retina by photocoagulation. The superior-temporal quadrant of one eye of 15 adult cats was photocoagulated by argon laser. The ERG was recorded at baseline and followed for up to 13 weeks postlaser. The retina was also observed ophthalmoscopically. Immediately after photocoagulation, the b-wave amplitude was markedly reduced. This was followed by a gradual recovery over the next 10 weeks. The ophthalmoscopic appearance of the lesions, however, appeared unchanged after 1 week. The ERG, which is reduced in amplitude immediately after retinal photocoagulation, shows recovery with time.

Animals↗
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Does a cytoplasmic bridge connect the CNS axon with the inner loop of myelin?

Sarah Luse (1959) reported over 30 years ago on the presence of a bridge connecting the axon to the myelin sheath in the central nervous system (CNS). This notion has not been accepted in the literature. Wolman (1992) found that the progress of demyelination in some viral diseases affecting the CNS fits the concept of Luse, as the process occurred primarily along the major dense line of myelin, which is in continuity with the cytoplasm of the oligodendroglial cell. Injection of Lucifer yellow (LY) and horseradish peroxidase (HRP) into the vitreous of guinea pigs, with and without iontophoresis, resulted in labeling of the nerve axons and myelin. Labeling of myelin by HRP occurred along the major dense line which indicated that a transient or permanent cytoplasmic bridge connects axons and myelin in the optic nerve.

Animals↗
PubMedDate not supplied

[Study of the antigenic structure of human immunoglobulin lambda-chain using monoclonal antibodies].

Nine monoclonals against human Ig lambda chains were produced, 4 antibodies react with C-domain, 5--with V-domain of the lambda chain. Anti-C lambda domain antibodies recognize not less than 3 epitopes and one of them is expressed only on the isolated chain. Anti-V lambda antibodies bind both isolated lambda chain and intact IgG, IgM, IgA. Four epitopes are expressed by few lambda Bence Jones proteins of the III subgroup, the immunogen possessing the same isotype. The 4 mentioned epitopes represent private idiotypic determinants. The epitope 3E10 is characteristic of 50% Bence Jones proteins of the II and III V lambda-subgroups thus representing a common idiotypic determinant. Using anti-V lambda antibodies germ line variability of V lambda III proteins was analysed and the similarity of antigenic structure of normal and myeloma human Ig lambda chains was demonstrated.

Antibodies, Monoclonal↗
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[Antigenic determinants of the constant region of human immunoglobin kappa-chain detected by monoclonal antibodies].

Ten different monoclonal antibody (monAB) preparations reacting with human IgL chains of the kappa type have been obtained. Nine of the monAB interacted with the kappa-chain C domain, whereas only one monAB reacted with the V domain. It has been determined that monAB against the C domain react with three different epitopes. One epitope is expressed on intact Ig molecules as well as on isolated kappa-chains, whereas the other two epitopes are found only on isolated kappa-chains. The expression of these epitopes in 40 different myeloma kappa-chain preparations belonging to four various subgroups was studied. The level of this C domain epitope expression has been shown to depend on the variable subgroups of kappa-chains indicating a close association between V and C domains. This association leads to the alteration of antigenic activity of some C domain epitopes. The alterations are thought to be local because, as a rule, they involve only one of the three epitopes.

Antibodies, Monoclonal↗
PubMedDate not supplied

Unilateral vascular plethora--a sign in advanced unilateral basal bronchiectasis.

Unilateral basal bronchiectasis results in a regional high vascular pressure and the flow of blood is thereby diverted to the uninvolved portion of the lung through bronchopulmonary anastomoses. Unilateral plethora of the upper lobe vessels in significant basal bronchiectasis of the same lung constitutes an important additional sign in the recognition of bronchiectasis on the plain chest radiograph. Attention is drawn to the fact that this will not occur if the adjacent lung is compromised by a related or unrelated disease process.

Adolescent↗
PubMedDate not supplied

Shifting pleural effusions.

The patient's position in bed may cause repositioning of free pleural fluid, which can track to paravertebral, subpulmonary, and paramediastinal planes. Awareness of this situation aids the clinician's recognition of the nature of the lesion on chest roentgenograms.

Humans↗
PubMedDate not supplied

Aspergillus in the lung.

There is an increasing incidence of deep mycotic infections. The initial clue to the diagnosis is often radiologic. It is important therefore for the radiologist to be aware of these infections and the setting in which they occur, e.g., allergic bronchopulmonary aspergillosis in the asthmatic person, invasive aspergilliosis in the immune compromised host, and aspergilloma in cavitary lung disease. In so doing he can alert the clinician to the possibility of a mycotic infection and thus initiate further investigation to confirm the diagnosis.

Adult↗
PubMedDate not supplied

Use of the giant-pulse Nd:YAG laser for ab-externo sclerostomy in rabbits and humans.

The giant-pulse Neodymium:YAG laser, a recently developed laser source, delivers up to 200 W of peak power at pulse widths of 20 or 40 msec. The instrument can create a sclerostomy with minimal surrounding damage and, consequently, relatively little postsurgical inflammation and scarring. We tested its efficacy in performing ab-externo sclerostomy in 10 adult pigmented rabbits and in five patients with end-stage glaucoma. All of the animal eyes were hypotonus immediately after the procedure. However, the intraocular pressure increased gradually, and by the third day, returned to presurgical levels in all of the eyes. All five of the glaucoma patients treated had patent sclerostomies following the procedure. They all had early hypotony, but after 3 months, four of the five sclerostomies apparently failed. The giant-pulse Nd:YAG laser appears useful for performing sclerostomy, but modifications are needed to solve the problems of early hypotony and late closure of the fistulula.

Animals↗