Search PubMed⌕ Search

Biomedical subjects

A Solomon

Publications and source records attributed to A Solomon.

At least 379 records · Page 21Linked to original sources
PubMed1966

Low-molecular-weight proteins related to Bence Jones proteins in multiple myeloma.

Urinary proteins distinct from Bence Jones proteins, but sharing antigenic determinants, were found in the urine of a number of patients with multiple myeloma. These components were smaller in size and antigenically deficient compared with Bence Jones proteins. They were best detected with antiserums to the homologous Bence Jones proteins and, in some cases, were related to the variable portion of the Bence Jones protein molecule.

Bence Jones Protein↗
PubMedDate not supplied

Abdominal findings in AIDS-related pulmonary tuberculosis correlated with associated CD4 levels.

BACKGROUND: To document the abdominal manifestations of tuberculosis (TB) associated with human immunodeficiency virus (HIV) infection and to correlate those findings with CD4 levels. METHODS: Twenty-nine HIV-positive patients with culture-proven Mycobacterium tuberculosis infection were entered into the study. Chest changes were used to separate patients into two groups: those with and those without evidence of previous TB. All patients had standard chest radiographs, routine and high-resolution chest computed tomography (CT), and abdominal ultrasound examinations. Twenty-four patients had abdominal CT scans. RESULTS: The group of patients with no previous radiographic evidence of pulmonary TB had a significantly greater tendency to have manifestations of pulmonary and/or abdominal miliary dissemination. Those patients with radiological evidence of miliary dissemination were significantly more likely to have CD4 counts of less than 300. CONCLUSIONS: Chest and abdominal miliary dissemination of TB in HIV-positive patients is significantly associated with radiologically determined primary onset pulmonary TB. These changes occur predominantly at CD4 counts of less than 300.

AIDS-Related Opportunistic Infections↗
PubMedDate not supplied

Serologic crossreactions among primate immunoglobulins.

We have generated and characterized 50 murine monoclonal antibodies (mAb) specific for baboon IgG. We examined crossreactivity of these mAb to baboon IgM and immunoglobulin (Ig) of various other primates including human, chimpanzee, rhesus monkey, cynomolgus monkey, and African green monkey. Those mAB that crossreacted with human IgG were further examined using myeloma proteins for specificity to human Ig subclasses. One mAB crossreacted with all four human IgG subclasses and with human IgM. We further analyzed this reactivity utilizing Bence Jones proteins representative of various light (L) chain germline gene family products. This mAB reacted with Bence Jones proteins indicating the recognition of a kappa (k) L chain specificity associated with the kappa I, kappa III, and kappa IV subgroups, but not with kappa II. Based on the differences between kappa II germ line gene encoded L chains and the other kappa L chain subgroups, we ascribe this reactivity to six amino acids that define a discontinuous epitope.

Animals↗
PubMedDate not supplied

Pulmonary changes in angioimmunoblastic lymphadenopathy as demonstrated by computerized tomography.

A case of angioimmunoblastic lymphadenopathy with pulmonary involvement is presented. The radiographic and computerized tomographic findings included multiple opacities, predominantly basal, of variable size. Associated pleural opacification was verified on both the chest roentgenogram and the computerized tomographic (CT) examination. The entity may mimic many more common clinical disease states and final diagnosis can only be established histologically.

Aged↗
PubMedDate not supplied

Computerized tomography in conditions concomitantly involving the orbits and the paranasal sinuses.

Forty-three patients with computerized tomographic (CT) findings demonstrating concomitant orbital and paranasal sinus involvement are presented. Exophthalmos was the most common presenting symptom. Ethmoid and maxillary sinuses were most commonly affected. CT findings were of help in evaluating the extent of the various disease processes and are mandatory for treatment planning. Attention is drawn to the common association of paranasal lesion and ophthalmic manifestations. The combination of clinical presentation and radiological findings might indicate certain etiologies.

Adolescent↗
PubMedDate not supplied

The electrocardiographic features of hypothermia.

Hypothermia results in the development of several characteristic electrocardiographic changes. As the core body temperature decreases, several changes in cardiac rhythm occur. Prolongation of the PR, QRS, and QT intervals are also seen. Muscle tremor artifact may be present, even in the absence of clinical shivering. A characteristic secondary deflection on the terminal portion of the QRS complex (Osborn wave) is usually found. All of these features are reversible with rewarming.

Arrhythmias, Cardiac↗
PubMedDate not supplied

Contribution of human V kappa II germ-line genes to light-chain diversity.

The genetic basis of the antibody repertoire--estimated to exceed 10(6) different immunoglobulin molecules--is a major unanswered problem. The number of germ-line V kappa genes in the mouse genome is probably several hundred while the corresponding number for three out of four human V kappa subgroups (V kappa I, V kappa III and V kappa IV) is probably altogether only 15-20 (ref. 5). The kappa II proteins differ significantly in sequence from the other kappa-chain proteins. To determine the contribution of V kappa II genes to kappa-chain diversity, we searched for a human lymphoid cell line which produces a kappa II chain and report here for the first time the sequence of a V kappa II gene. According to blot hybridizations with this V kappa gene as a probe, subgroup II contributes about half as many genes to the V kappa gene repertoire as are detected by a V kappa I probe. Therefore the repertoire is rather small which implies that somatic mutations or other mechanisms must play an important role in the generation of light-chain diversity in humans.

Amino Acid Sequence↗