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Biomedical subjects

A Singh

Publications and source records attributed to A Singh.

At least 775 records · Page 43Linked to original sources
PubMed1981

Ultrastructural alterations in the liver of rats fed photomirex (8-monohydromirex).

Alterations in the liver of rats fed photomirex or mirex for 28 d have been studied by electron microscopy. A dose of 0.05 or 0.5 ppm photomirex produced selective ultrastructural damage to the mitochondria of hepatocytes. The parenchymal cells had a proliferation of smooth-surfaced endoplasmic reticulum (SER) with a concomitant depletion of glycogen, a reduction of rough-surfaced endoplasmic reticulum (RER) profiles, an abnormal accumulation of lipid droplets, and pleomorphic nuclei at the 5 ppm photomirex level. In the animals receiving 50 ppm photomirex there were degenerating foci in the organ. There was an increase of electron-dense bodies in the hepatocytes from the 5 ppm mirex group but these cells, in the animals receiving 50 ppm mirex, had SER proliferation and glycogen depletion. It is concluded that photomirex causes more severe ultrastructural changes in the livers of rats than mirex.

Animals↗
PubMed1981

Liver ultrastructure in pigs fed various oils.

In order to determine the effects of various dietary oils on the porcine liver, four groups of 10- to 11-week-old pigs received feed supplemented with either 10 per cent rapeseed oil (RO) of Tower (0.4 per cent erucic acid) or Target (30.2 per cent erucic acid) varieties, Atlantic herring oil, or soybean oil for 10 weeks. The ultrastructural appearance of the livers from pigs of a fifth group receiving no oil was compared with that from the livers of pigs fed dietary supplements of the four oils. Alterations induced by Tower RO (low erucic acid content) consisted of an increase in the extent and number of the following features in the hepatocytes: an increased number of tortuous cisternae of rough surfaced endoplasmic reticulum, signet ring-shaped mitochondria and cytoplasmic lacunae. Bile canalicular lumina were occluded by swollen microvilli and, or, globules of a lipid-like material. Alterations caused by Target RO (high erucic acid content) in hepatocytes were similar to those induced by Tower RO. Lesions seen in the pigs fed herring oil included an excess of membrane limited lipid droplets and an accumulation of electron dense bodies in the Golgi zone of liver parenchymal cells. Many bile canaliculi were dilated. A soybean oil supplement resulted in an accumulation of clusters of minute lipid droplets in hepatocytes and a stacking of mitochondrial cristae. It is concluded that the alterations represent functional modifications of hepatocytic metabolism in response to the oil supplements.

Animals↗
PubMed1981

Prepenile scrotum.

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Child, Preschool↗
PubMed1980

LeVeen shunt patency studies: clarification of scinigraphic findings.

In an experimental model we have demonstrated that visualization of the target organ is the only dependable criterion for the scintigraphic evaluation of LeVeen shunt patency or nonpatency. The lungs are best suited as the target, because the presence or absence of pulmonary uptake can be easily seen without interference from radiolabeled peritoneal fluid. Proof of shunt patency should not rely upon direct visualization of shunt tubing, because very high or low flow rates are both associated with poor visualization. Maximum accumulation of activity in the shunt tubing occurs with intermediate flow rates (approximately 60 cc/hr).

Ascites↗