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Biomedical subjects

A Shibata

Publications and source records attributed to A Shibata.

At least 685 records · Page 38Linked to original sources
PubMed1981

[Regional wall motion of the left ventricle in congestive cardiomyopathy: in comparison with progressive muscular dystrophy of Duchenne type (author's transl)].

The features of regional wall motion abnormalities of the left ventricle were analysed in 11 patients of congestive cardiomyopathy (CCM) in comparison with 22 patients of progressive muscular dystrophy (DMD) of Duchenne type who showed an abnormal motion of the left ventricle by echocardiography. Real time two-dimensional echocardiographic study demonstrated the following results: I) In CCM, (1) only 2 or less of 11 cases preserved a normal motion in each left ventricular segment, and the depression of wall motion of the left ventricle were thought to be generalized; (2) there were 9 cases with segmental wall motion abnormalities and 3 of them demonstrated ventricular aneurysms, and (3) the localizations of the segmental abnormalities varied in each case, and there was no apparent accumulation to any segments. II) In DMD, (1) all the cases showed depressed motions and 8 of them demonstrated a ventricular aneurysm in the posterior wall of the left ventricle (LVPW), (2) while, there was no case showing ventricular aneurysm in the segments other than LVPW, and about one third of all cases showed normal motion in those segments. From these results, we concluded as follows: 1) Although the depression of a wall motion of the left ventricle was generalized in CCM, this was not always uniform and the segmental abnormalities of a wall motion were frequently observed. The localization of the most severely disturbed segment varied in each case. 2) On the other hand, in DMD, the wall motion was disturbed more frequently and more severely in LVPW than in other ventricular segments.

Adolescent↗
PubMed1980

Von Willebrand disease with an increased ristocetin-induced platelet aggregation and a qualitative abnormality of the factor VIII protein.

Two cases of von Willebrand disease (VWD) that revelaed an increased ristocetin-induced platelet aggregation (RIPA) and a qualitative abnormality of the factor VIII protein are reported. The threshold concentration of ristocetin giving a 30% increase in light transmission was 0.5 mg/ml in the proband and 0.4 mg/ml in her father (normal: 1.16 +/- SD 0.18 mg/ml) although both patients showed reduced plasma von Willebrand factor activity (VIIIR:WF). In both patients, the amount of factor VIII related antigen (VIIIR:AG) in their platelets were normal, but an increased binding affinity of platelets to plasma factor VIII was demonstrated. The qualitative abnormality of the factor VIII protein was characterized by an increasead anodal migration of VIIIR:AG in crossed immunoelectrophoresis (CIE), a delayed elution pattern as demonstrated by gel filtration on Sepharose 2B, and a decreased precipitation with concanavalin A (Con A). The response to DDAVP was also investigated.

Adult↗
PubMed1980

Enhanced neurotensin-like immunoreactivity release in total gastrectomized patients after 50 g OGTT.

Neurotensin, originally isolated from the bovine hypothalamus (Carraway and Leeman 1973) is found not only in several parts of the brain (Carraway and Leeman 1976a) but also in the lower intestine (Orci, Baetens, Rufener, Brown, Vale and Guillemin 1976). Although neurotensin has a wide range of pharmacological effects (Carraway, Demer and Leeman 1976b), the concentrated localization of this peptide in the gut suggests that neurotensin may play a pathophysiological role in the gut disease. Recently, Bloom, Blackburn, Ebeid, Ralphs and Polak (1978) proposed the hypothesis that neurotensin may play an important role in the pathogenesis of dumping syndrome, based on measurement of plasma neutrotensin levels in gastrectomized patients. To examine the hypothesis, we compared changes of plasma neurotensin levels after 50 g OGTT in total gastrectomized patients with those in control subjects. In this paper, we report on enhanced neurotensin like immunoreactivity (NTLI) release in gastrectomized patients after 50 g OGTT.

Adult↗
PubMed1980

Quantitative analysis of thallium-201 uptake and the effect of heart rate.

In the successive myocardial imaging by thallium-201, the uptake by myocardial cells was assessed quantitatively. At a steady hemodynamic state, the second uptake was able to be predicted from the first uptake count and the ratio of the first and the second background counts. This predicted counts showed a high correlation with the actual counts (r = 0.987, p < 0.001). No significant difference was observed in two counts. When heart rate was increased in six patients who were implanted a programmable pacemaker during the second myocardial imaging, the actual counts exceeded the predicted ones significantly (p < 0.001). An increase of the counts by 36% was observed in the average following the change of heart rate from 60 beats/min to 90 beats/min. Since the tissue level of uptake is dependent upon the blood level and the partition coefficient, this increase of myocardial uptake suggests an alteration in the partition coefficient.

Adult↗
PubMed1980

Radioimmunoassay of neurotensin and the distribution and concentration of gut neurotensin in rat and dog.

A specific radioimmunoassay (RIA) for neurotensin (NT) has been developed. Four antisera of high avidity were raised in 4 rabbits immunized with synthetic NT tridecapeptide coupled with bovine serum albumin via glutaraldehyde. NT was labeled with Na125I by means of modified Hunter-Greenwood's chloramine-T method. Sensitivity of the RIA was 100 pg/ml. Cross-reactivity of antiserum to other peptides was not observed. Using the RIA, the distribution and concentration of gastrointestinal (GI)-NT have been determined in acid-acetone extracts of rat and dog GI tissues. RIA using four kinds of antisera similarly detected higher concentrations in jejuno-ileal sections than in other regions. Although the distribution of GI-NT was quite similar between rat and dog, its concentration showed species specific difference.

Animals↗
PubMed1980

Properties of the factor VIII after DDAVP (1-deamino-8-D-arginine vasopressin) infusion in normal subjects.

The factor VIII response to DDAVP (1-deamino-8-D-arginine vasopressin) was examined in 6 healthy volunteers. Following intravenous DDAVP infusion, each subject showed a marked increase in factor VIII procoagulant activity (VIII:C), factor VIII related antigen (VIIIR:AG) and von Willebrand factor activity (VIIIR:WF). But there were differences among augmentation index of each activity. Further investigations were performed whether there was a qualitative abnormality in the factor VIII after DDAVP infusion. Between factor VIII activities before and after DDAVP, there was no difference in a thermostability of VIII:C in vitro, gel chromatographic pattern on Sepharose 2B or 4B, a precipitation with concanavalin A (Con A) and a recovery in cryoprecipitate. The increase of VIIIR:AG, however, was mostly brought about by the augmentation of relatively slowly migrating portion as demonstrated by crossed immunoelectrophoresis (CIE). From these results it was assumed that there was no remarkable abnormalities in the factor VIII after DDAVP administration, and the elevated factor VIII could function efficiently in vivo. The findings in cryoprecipitation showed that DDAVP could be applied to blood donation for the preparation of cryoprecipitate.

Arginine Vasopressin↗
PubMed1980

Decreased precipitation of factor VIII related antigen with concanavalin A in patients with a variant of von Willebrand's disease and disseminated intravascular coagulation.

Precipitation pattern of factor VIII related antigen (VIIIR:AG) with concanavalin A (Con A), a glycoprotein binding lectin, was investigated in normal subjects and patients with a variant of von Willebrand's disease (VWD) and disseminated intravascular coagulation (DIC). Decreased precipitation with Con A was demonstrated in patients with a variant of VWD in which VIIIR:AG showed an increase in electrophoretic mobility on crossed immunoelectrophoresis (CIE). Similar findings were obtained in patients with DIC which revealed normal electrophoretic mobility of VIIIR:AG. This procedure was assumed to be useful for the detection of a qualitative abnormality of the factor VIII protein.

Antigens↗
PubMed1980

Fluid kinetics during hemodialysis.

The reflection coefficient of urea was estimated in the present paper since some clinical experiences suggest an importance of urea dependent osmolality for the circulatory stability. In the physiology, the reflection coefficient of urea is usually regarded to be negligibly small though it varies from one organ to another. The value obtained in the present paper is large and urea was supposed osmotically to be active affecting the fluid movement across the capillary wall. A fall of urea concentration during hemodialysis may aggravate potentially the decrease of circulating blood volume.

Capillary Permeability↗