Sex chromosomal abnormalities in India.
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Biomedical subjects
Publications and source records attributed to A Sharma.
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The experimental data on the absorption of a plane polarised light by a solution of cattle rhodopsin at -196 degrees C have been theoretically analysed to model the directional absorption properties of rhodopsin and its photoproducts. It is seen that these molecules behave like planar absorbers having a ratio of about 100 : 7 between the extinction coefficients along the long axis and perpendicular to it. Using this result and the experimental observations on absorption and dichroism in the retina in situ, a model for the configuration of chromophores in the disc membranes has been derived. In this model the plane of the chromophore is perpendicular to that of the disc and the long axis of the chromophore makes an angle of 6.6 degrees with the plane of the disc. The solution of the problem depends on the assumption that the absorption axes are the same for the rhodopsin, prelumirhodopsin and isorhodopsin.
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The occurrence of different types of hemoglobin variants in India has been well-documented in urban populations and in certain tribal areas. Beta-thalassaemia and hemoglobins D,E,H,S, and rare variants like Hb Lepore, have been found in varying percentages. There is a higher incidence of Hb E in the Eastern region and of Hb D in certain Northern populations. The association of Hb E with beta thalassaemia G6PD deficiency has been established. The relationship with other environmental factors, like malaria, is not yet clear.
Total protein patterns of amniotic fluid samples of different age groups, following polyacrylamide disc gel electrophoresis, showed a wide range of variation in early pregnancy, but no two cases had identical banding, indenticating their genetic variability. An assessment has been made here of the total protein, albumin and transferrin patterns from normal fluids of different age groups by gel electrophoresis, in order to observe the genetic variations and relationship with foetal age, if any.
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Bilateral inked palmar impressions of 150 male tubercular patients and those of 150 normal controls (males) have been studied comparatively. Patients and controls show deviation from each other with respect to 1. biological concordance-disconcordance in line C and hypothenar patterns, 2. bilateral and left-homolateral (not right) differences in Plato's modal types of line C and 3. occurrence of hypothenar (R + L only) and III interdigital patterns (L-homolateral only). It is significant that tubercular patients do not show any difference with the normal controls in a reliable measure like main-line-index and by and large in occurrence of patterns also (with two exceptions only). Natural selection does not seem to be operative on palmar dermatoglyphic traits.
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