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Biomedical subjects

A Scott

Publications and source records attributed to A Scott.

At least 307 records · Page 17Linked to original sources
PubMed1979

Metabolic changes during dopamine infusion in dogs.

The effects were investigated, in 12 dogs, of the infusion of dopamine 10 or 30 micrograms kg-1 min-1 on circulating glucose, glycerol, lactate and potassium concentrations. Both doses of dopamine produced in initial increase in blood glucose concentration (P less than 0.05) followed by hypoglycaemia (P less than 0.05). Lipolysis was stimulated as shown by an increase in plasma glycerol concentrations with dopamine 10 micrograms kg-1 min-1 (P less than 0.05) and dopamine 3 micrograms kg-1 min-1 (P less than 0.01). Blood lactate concentrations increased slightly in both groups, but this was significant (P less than 0.05) only in the dogs infused with dopamine 10 micrograms kg-1 min-1. Dopamine had no significant effect on the plasma potassium concentration.

Animals↗
PubMed1978

A comparison of the cardiorespiratory effects of continuous positive airway pressure breathing and continuous positive pressure ventilation in dogs.

Five patterns of ventilation have been compared in dogs: (1) spontaneous ventilation at ambient pressure (SV); (2) intermittent positive pressure ventilation (IPPV); (3) spontaneous ventilation at 0.98 kPa positive airway pressure, delivered from a non-rebreathing circuit incorporating a 5-litre reservoir bag and fresh-gas flow of twice the minute volume (CPAP (bag)); (4) spontaneous ventilation at 0.98 kPa positive airway pressure, with the reservoir bag replaced by a weighted bellows (CPAP (bellows)) and (5) IPPV with 0.98 kPa positive end-expiratory pressure (CPPV). CPAP significantly decreased the rate of respiration compared with SV. CPAP (bellows) resulted in a significant increase in tidal volume. Mean oesophageal pressure, right atrial pressure, pulmonary wedge pressure and pulmonary artery pressure increased during IPPV, CPAP (bag), CPAP (bellows), and CPPV compared with SV. There were no significant changes in mean systemic arterial pressure, cardiac output, PaO2, PaCO2, CaO2, (CaO2-CVO2), PAO2-PAO2) or pulmonary venous admixture. Under the conditions of this study oxygen transport was not altered by positive airway pressure ventilation.

Animals↗
PubMed1975

Prophylactic oral antimicrobial agents in elective colonic surgery. A controlled trial.

A controlled trial has been carried out in 50 patients undergoing elective colonic surgery to assess the efficacy of prophylactic oral metronidazole specifically directed against anaerobic colonic microflora in combination with kanamycin to reduce the aerobic flora. A control group received dietary and mechanical preparation alone. A significant reduction of both aerobic and anaerobic colonic microflora was achieved in the group receiving prophylactic antimicrobial agents, and this was reflected in a significant reduction in postoperative wound infections. 1 control patient died from Bacteroides septicaemia. No toxic or other side-effects from this prophylactic regimen occurred in this trial.

Administration, Oral↗
PubMed1974

Drug interactions.

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Drug Antagonism↗
PubMed1974

Drugs and pregnancy.

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Abnormalities, Drug-Induced↗