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Biomedical subjects

A Schaller

Publications and source records attributed to A Schaller.

At least 73 records · Page 4Linked to original sources
PubMed1990

Purification of chorismate synthase from a cell culture of the higher plant Corydalis sempervirens Pers.

Chorismate synthase (EC 4.6.1.4) was purified from a cell suspension culture of Corydalis sempervirens almost 1000-fold to near homogeneity. The subunit Mr estimated by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate was 41,900. The Mr of the native enzyme was estimated to be 80,100 by gel filtration, suggesting a dimeric structure. Antisera directed against the 41.9-kDa protein also reacted with the native enzyme. Further confirmation of the identity of the purified protein was obtained by sequence comparison of a tryptic peptide with known sequences of the Escherichia coli and Neurospora crassa chorismate synthases.

Amino Acid Sequence↗
PubMed1989

[Uterine growth in the endometrium active phase].

Paediatric and adolescent gynaecology still lacks normal values for the size of the uterus from the post partum period up to early puberty. The relevant literature fails to provide reliable information concerning this subject. Anatomical studies by ultrasound yielded controversial results. We have performed a morphometric study on a random sample of corpses and found a longitudinal growth of the uterus of about 10 mm during the period of dormant endometrium i.e. between the first and eleventh year of life. During the 12th to the 14th year we found an accelerated growth, amounting to altogether 20-30 mm. A shift in the cervix-corpus proportions as reported previously was not observed. However, the longitudinal growth, as well as the distance between the portio and fundus, which is clinically more important, seemed to correlate with the girl's body weight and height. The broadwise growth correlated with the girl's age. These observations allow us to speculate on the organ's options for further differentiation, especially during the post partum period and to evaluate the effect of early puberty on the increment of uterine size.

Adolescent↗
PubMed1988

[Sex offenses on minor girls. Pediatric gynecologic management].

This report on 24 cases of sex offences on girls under 14 years of age examined and treated at the 2nd University Department of Obstetrics and Gynaecology in Vienna covers the period between 1984 and 1987. Experience gained in these cases led to the development of a specially devised mode of management which ranges from guidelines on supplementary history taking to special examinations and deals in particular with the after care of these young girls, which is a largely neglected area. The responsibility of the examining gynaecologist towards the victim as well as towards the person suspected of a sex offence is stressed. An obvious change in the accompanying circumstances and their possible causes are discussed.

Adolescent↗
PubMed1988

Successful outcome of a complicated pregnancy in a renal transplant recipient taking cyclosporine A.

The successful outcome of a pregnancy complicated by reversible renal failure secondary to total ureteral obstruction caused by a pregnant uterus and treated temporarily with nephrostomy is reported. The cyclosporine A (CsA) and prednisone treated female recipient of a cadaveric renal allograft gave birth to a male child, which at 2080 grams was small for gestational age (35 weeks of pregnancy). The child presented neither signs of congenital anomalies or chromosome aberrations nor nephrotoxicity, hepatotoxicity or anemia. Simultaneous measurement of trough CsA blood levels (CsA RIA, Sandoz) displayed reduced values in the child's blood (mother 864 ng/ml-4 hours after oral CsA intake; son 312 ng/ml). Beside postrenal failure the patient's pregnancy was complicated by 7 rejection episodes treated with high doses of methylprednisone (total dose 5 g) with reversible damage of the transplant function, two episodes of a urinary tract infection and increasing anemia necessitating blood transfusions. The HIV negative patient had developed a Kaposi's sarcoma 6 weeks after grafting. The progression of infiltrating skin lesions during pregnancy was not seen.

Adult↗
PubMed1987

[Upper Austria model study to assess the prevalence and incidence of congenital abnormalities].

Among the 15.998 live births recorded in Upper Austria in the year 1985, a representative malformation rate of 1.79, respectively a representative incidence of 17.94 in 1000 live births is reported. The incidences of characteristic malformations and of single malformations combined in malformation groups are determined. An instrument of investigation, especially developed for and successfully used in this examination in form of an illustrated questionnaire is introduced.

Austria↗
PubMed1987

[Pregnancy and labor following kidney transplantation with cyclosporin A. Case report and review of the literature].

We report on a 22-year old patient who received a cadaveric renal transplant following haemodialysis treatment for five months due to endstage chronic glomerulonephritis. 14 months after successful transplantation while on stable renal function (serum-creatinine 1.0-1.4 mg%) the patient became pregnant. As an immunosuppressive therapy the patient got cyclosporine A and cortisone. The monitoring of the immunosuppressive therapy (Cyclosporine A) was performed by daily measurement of serum concentration by radioimmunoassay. Drug administration was adjusted to maintain serum levels of 250-550 ng/ml. Increased dosages were required from 25th week until delivery. Until the 25th week of gestation the pregnancy was uncomplicated from both the nephrological and obstetrical points of view. At the 25th week of gestation the patient became anuric. This was caused by a postrenal failure due to the compression of the transplantar ureter by the pregnant uterus. Nephrostomy was installed and was used until the end of pregnancy. In the third trimester the foetus showed growth retardation. For this reason a Caesarean section was necessary at the 36th week of gestation. A healthy boy was delivered weighing 2080 g and measuring 45 cm. No congenital malformations were observed, the chromosomal analysis showed no aberrations. After the delivery cyclosporine concentrations in the blood of the mother and the newborn were simultaneously measured. A remarkable difference in these concentrations was observed particularly in the mother's blood 864 ng/ml whereas in the baby's blood the concentration was 312 ng/ml. Three days after the delivery the patient was able to urinate normally so that the nephrostomy could be removed.

Cyclosporins↗
PubMed1985

The prevalence of ureaplasma, mycoplasma and antibodies against chlamydia group antigen in gynecological outpatients.

177 women with an average age of 30 years were investigated for ureaplasma, mycoplasma and for antibodies against the chlamydia group antigen. Specimen of endocervical mucus and catheter specimens of urine were cultured and the ELISA ("enzyme-linked immunosorbent assay") technique applied. In addition the purity class (I to III) of gram-stained vaginal smears was determined. Ureaplasma were isolated from 45.8 and 26.0%, mycoplasma from 9.0 and 7.9% of cervical and urine specimens respectively. The patients were divided into 5 clinical groups. Patients in the first three groups (I-III, inflammatory disorders, bleeding anomalies, benign and malignant neoplasms of the genital tract) showed a significantly (p less than or equal to 0.05) higher colony count of ureaplasma in their urine than patients in the other two groups (IV and V, who had attended the hospital for reproductive problems or for routine examination). There was a clear correlation between the isolation rates of ureaplasma and mycoplasma and the purity classes of the vaginal smears. The rate of isolation increased progressively with class II and III smears. Antibodies against the chlamydia group antigen were detected in about 40% of all sera tested. A very high titer of antibodies reflecting a recent chlamydial infection was found in 11% of the sera tested.

Adolescent↗
PubMed1985

[Problems in the prenatal diagnosis of fetal microcephaly].

By the example of a case of lissencephalia the problems of prenatal diagnosis of the very rare, genuine fetal microcephalia are demonstrated: differentiation to pseudomicrocephalia, vague to missing midline echo, lacking possibility of radiological objectification.

Abortion, Induced↗
PubMed1984

[Velamentous insertion--epidemiology and clinical aspects of the pathological insertion of the umbilical cord].

Among 9460 birth an incidence of 1.6% of velamentous insertion of the umbilical cord is recorded and the clinical relevance of this anomaly is examined. Apart from statistical confirmation of well-known connections between membranous insertion of the umbilical cord on the one hand, and malformations, multiple pregnancies and bleeding sub partu on the other hand, the present investigation is mainly concerned with premature births and/or placental insufficiency in the case of velamentous insertion of the umbilical cord, which is associated with "late premature births" in the 35th, 36th and 37th week of pregnancy as characteristic finding.

Adult↗