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Biomedical subjects

A Schaefer

Publications and source records attributed to A Schaefer.

128 records · Page 8Linked to original sources
PubMedDate not supplied

Therapeutic delivery systems: a new approach to evaluate physical properties of transdermal delivery systems (TDS).

In the present paper a new methodological setup to objectify the parameters adhesiveness and adhesive strengths of Transdermal Delivery Systems is presented. The setup includes 6 steps: Evaluation of skin type, application of the patch by a pneumatic device, evaluation of detached area of the patch by planimetric means, assessment of the adhesive strength by a patch removal unit, evaluation of reddening of the skin, and examination for water uptake of the skin layers by high resolution ultrasound. Each step is described individually. Further problems arising from studies performed with this methodological setup concerning possible adhesive-drug interactions as well as uncorrelated drug behavior to nondetached area of the patch with regard to the pharmacokinetic profile are discussed.

Administration, Cutaneous↗
PubMedDate not supplied

In vivo requirement for asialo GM1 and Thy1 positive leukocytes for antitumor effect of rIL-2 +/- rIFN-gamma.

Localized treatment with recombinant human interleukin-2 (rIL-2) +/- recombinant murine interferon-gamma (rIFN-gamma) results in regression of early B16 melanomas in normal C57BL/6 (B6) mice, but not in syngeneic beige mice, which have defective natural killer (NK) cells. Injection of antibodies to asialo GM1 (a-AGM1) or Thy1 abolishes the tymoricidal effects of rIL-1 +/- rIFN-gamma. Thus, cells activated by these cytokines must be either NK-like cells that are AGM1+ Thy1+, or NK-like cells (AGM1+) cooperating with T lymphocytes (Thy1+), since either antibody (a-AGM1 or a-Thy1) independently abrogates the in vivo antitumor effect.

Animals↗