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Biomedical subjects

A S Carter-Finch

Publications and source records attributed to A S Carter-Finch.

2 recordsLinked to original sources

Electrochromatography.

Although Mould and Synge were credited with the first demonstration of the use of electroosmotic flow to drive a liquid in a thin-layer chromatography system, it was the work of Knox and Grant that extensively detailed much of both the theoretical and practical implications of capillary electrochromatography. This review is aimed at giving a very broad outline of the progression of this technique since the late 1980s up to the present time, including some of the current limitations. Examples will be given of the analysis of a wide variety of materials including neutral, acidic, basic and chiral pharmaceutical compounds, along with some of the instrumentation used for this technique.

Chromatography, Micellar Electrokinetic Capillary↗

Enantiomeric separations by capillary electrochromatography using a macrocyclic antibiotic chiral stationary phase.

Racemic mixtures of tryptophan and dinitrobenzoyl leucine have been successfully resolved by capillary electrochromatography (CEC) using the macrocyclic antibiotic teicoplanin, covalently bonded to a 5 microns silica support. Modification of a previously published packing procedure was required to pack reliable capillaries, capable of performing enantiomeric separations. Good levels of enantioselectivity were obtained in all cases, with optimised separations being performed in less than 6 min. Retention times, resolution and reproducibility are discussed.

Anti-Bacterial Agents↗