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Biomedical subjects

A Roth

Publications and source records attributed to A Roth.

At least 469 records · Page 26Linked to original sources
PubMedDate not supplied

Anterior disc displacement without reduction in the temporomandibular joint: MRI and associated clinical findings.

To determine the value of MRI in temporomandibular joint (TMJ) disorders, the data of MRI-proven anterior disc dislocation without reduction (ADWOR) were correlated with clinical history and clinical data. MRI demonstrated degenerative bony changes and a reduced sagittal diameter of the condyle, a variable degree of disc deformation, and a thinned bilaminar zone in each of the joints with ADWOR, which clearly differed from patients with anterior disc dislocation with reduction (ADWR) (P = .01) and normal disc position (NDP) (P < .001). Of 59 patients and 83 TMJs that had been investigated in a 2-year period, as shown by MRI, 22 patients (27 TMJs) had ADWOR (32%), 16 joints had NDP (19%), and 40 patients had ADWR (49%). In patients with ADWOR, the clinical history revealed pain in either of the joints and/or cervical or masticatory muscles in 25 (93%) joints. Clinical investigation revealed various abnormalities in 22 joints; five of those presented without any pathologic clinical finding. Mouth opening was unlimited in nine patients (47%), palpation of the muscles of mastication was painless in 13 patients (52%), and joint noises during mouth opening or closing were noted in 14 patients (56%). According to clinical histories, four patients were suspected to have become symptomatic only after dental treatment. ADWOR is difficult to diagnose with clinical methods alone. The indication for MRI evaluation of the TMJ should be extended for asymptomatic patients with a history of limitation in mouth opening and pathologic x-ray morphology of the condyle. Because symptoms may arise after dental treatment in these patients, aggravation of internal derangement may be avoided by careful handling.

Adult↗
PubMedDate not supplied

Ablation of hepatocellular carcinoma by percutaneous ethanol injection: imaging findings.

Since PEI is a treatment based on imaging techniques, the radiologist should be familiar with the various findings that may be observed after PEI on US, CT, and MR images immediately after treatment and during later follow-up. Although US is well suited for performing PEI, contrast-enhanced CT currently is the most commonly used imaging method to evaluate the effect of PEI. Residual, nodular areas of contrast enhancement correlate well with residual tumor and warrant additional treatment. Although the findings on MR images obtained after PEI are more complex, MR imaging may be used as an alternative to CT.

Antineoplastic Agents↗
PubMedDate not supplied

Does adequate control of diabetes in the preinfarction period improve the short-term postinfarction course?

It is uncertain whether adequate preinfarction diabetes control would alter the clinical outcome in diabetic patients once myocardial infarction has occurred. This study attempts an evaluation. Diabetic patients admitted successively to the cardiac intensive care unit with their first acute myocardial infarction were enrolled and followed throughout hospitalization. Every fourth consecutive patient with infarction, but not diabetic, was assigned to a control group. All patients were kept in the cardiac care unit for at least 48 h and vital signs and cardiac arrhythmias were continuously monitored. Radionuclide ventriculography was done within 24 h of admission and again upon discharge. When feasible, patients with postinfarction angina underwent coronary balloon angioplasty. During a 1-year period, 49 diabetic patients were studied, while 18 comparable nondiabetic patients served as controls. Diabetes was considered adequately controlled in 16 patients with glycosylated hemoglobin (HbA1c) of 8.8 +/- 0.7%, whereas in 33 patients diabetes was uncontrolled (HbA1c 14 +/- 3%), p < 0.001. No difference was found in the extent of infarct size, occurrence of heart failure, arrhythmias, and mortality when comparing the adequately with the inadequately controlled diabetics during a hospitalization period of 11 days. In diabetics, no differences were found in the short-term clinical course after acute myocardial infarction, whether the diabetes was adequately controlled or not in the preinfarction period.

Analysis of Variance↗
PubMedDate not supplied

Naltrexone plus group therapy for the treatment of opiate-abusing health-care professionals.

PURPOSE: The success rate of a treatment program tailored to opioid-abusing health-care professionals that included oral naltrexone and group therapy was studied. METHODS: 20 opioid-abusing health professionals were treated over a 5-year-period. Clients received an initial assessment, supervised administration of naltrexone, and weekly attendance at a psychotherapy group for health professionals. Naltrexone was administered for the first several months, then patients continued the program without naltrexone. RESULTS: 18 patients were referred to the program after being caught diverting medication. Two patients came spontaneously. Of the 18 referred patients, 12 had no relapses, and 5 had only one relapse, followed by long-term sobriety. Mean overall duration of naltrexone administration was 8 months, and the mean duration in the program was 1.9 years. 94% of referred clients had long term abstinence, and 66% were working in their profession during the program. CONCLUSIONS: Naltrexone in the setting of a structured program is helpful in the treatment and professional reinstatement of opioid abusing health professionals.

Adult↗
PubMedDate not supplied

[Can the number of thromboembolisms incidents in total hips replacement be further reduced?].

QUESTION: Is it possible to reduce the rate of thrombembolic events during total hip arthroplasty (THA) by the intraoperative use of a mechanical device for thrombembolic prophylaxis (A-V Impulse System). METHOD: The efficacy of additional mechanical thrombembolic prophylaxis was investigated in a prospective randomised trial on 104 patients who underwent cementless THA. All patients received low dose heparin. In 52 patients the additional application of the A-V Impulse System was introduced intraoperatively for the next 24 h. A perfusion scintigram of the lung was performed before and 7 days after the operation in both groups to detect embolic patterns. RESULTS: Perfusion deficits typical for thromboembolic events were detected postoperatively in 8 patients (15.4 %) of the controls and 5 patients (9.6 %) of the A-V Impulse System group. CONCLUSIONS: With the perfusion lung scan we saw postoperatively a total of 13 patients (12.5 %, n=104) with an asymptomatic microthromboembolism of the lungs. Hence it is necessary to increase the protection against thromboembolism. Although statistically not significant (p=0.374), there is a tendency that the additional use of the mechanical thrombotic prophylaxis can reduce thromboembolic events in THA. The impact of the intraoperative introduction of the A-V Impulse System is not really clear. However, for a higher velocity of blood flow during the operation it makes sense to start the procedure intraoperatively.

Aged↗
PubMedDate not supplied

[A case report: ochronosis in combination with chondrocalcinosis].

We report the case of a 70 year old female patient suffering from Cox- and Gonarthrosis, a massive loss of function of the whole vertebral spine caused by a combination of Ochronosis and Chondrocalcinosis. The patient's anamnesis, the clinical findings and the pathology with the possible clinical manifestations are being described with a review on the existing literature.

Aged↗
PubMedDate not supplied

Wound coverage: is there a difference?

Many different wound-covering materials, making various claims regarding wound healing effectiveness, are currently available. However, no controlled, comparison trials have been performed to document these claims. This prospective, randomized study was undertaken to compare wound healing among several synthetic burn dressings. Micrografts were placed on 20 New Zealand white rabbits, then randomly covered with four commonly used synthetic burn dressings, to evaluate the impact on wound healing. No statistically significant difference in wound healing was observed among the dressings. With equal wound healing, the choice of wound coverage should be based on other factors such as availability, cost, and handling properties of the dressing.

Analysis of Variance↗
PubMedDate not supplied

Mood and somatic symptoms during pregnancy.

A predominantly white, middle class sample of pregnant women (N = 93) completed the AACL (Anxiety), the DACL (Depressive Mood), the SCL (Somatic Symptoms) and the IPAT Anxiety Questionnaire at the second, fifth and eighth months of pregnancy. A menstrual history questionnaire was administered on the first testing occasion. Analyses revealed that anxiety varied significantly as a function of trimester and that previous pregnancy history interacted significantly with trimester. Depressive mood was not significantly affected by any of the sources of variation. Correlational analysis (average correlations over trimesters) indicated significant relationships between somatic symptoms and anxiety, but not between somatic symptoms and depressive mood; a small but significant relationship between history of menstrual complaint and somatic symptoms; and a significant negative correlation between education and overt anxiety.

Abortion, Spontaneous↗
PubMedDate not supplied

Nonlinear anisotropic diffusion filtering of three-dimensional image data from two-photon microscopy.

Two-photon microscopy in combination with novel fluorescent labeling techniques enables imaging of three-dimensional neuronal morphologies in intact brain tissue. In principle it is now possible to automatically reconstruct the dendritic branching patterns of neurons from 3-D fluorescence image stacks. In practice however, the signal-to-noise ratio can be low, in particular in the case of thin dendrites or axons imaged relatively deep in the tissue. Here we present a nonlinear anisotropic diffusion filter that enhances the signal-to-noise ratio while preserving the original dimensions of the structural elements. The key idea is to use structural information in the raw data-the local moments of inertia-to locally control the strength and direction of diffusion filtering. A cylindrical dendrite, for example, is effectively smoothed only parallel to its longitudinal axis, not perpendicular to it. This is demonstrated for artificial data as well as for in vivo two-photon microscopic data from pyramidal neurons of rat neocortex. In both cases noise is averaged out along the dendrites, leading to bridging of apparent gaps, while dendritic diameters are not affected. The filter is a valuable general tool for smoothing cellular processes and is well suited for preparing data for subsequent image segmentation and neuron reconstruction.

Algorithms↗
PubMedDate not supplied

Therapy of advanced esophageal cancer with bleomycin, irradiation and combination of bleomycin with irradiation.

Results from treating 51 patients with advanced esophageal cancer are presented. Fifteen patients were treated with Bleomycin, 12 with radiotherapy, and 24 with a combination of bleomycin and radiotherapy. The best results were achieved in the group of patients treated with combined therapy showing 62% objective remissions (15/24) which was statistically significant (P less than 0.001) in comparison to the other groups. In the Bleomycin therapy group, there were 26% objective remissions (4/15), and in the group treated only with radiotherapy 33% (4/12)- The median duration of remission was 9 months in the combined therapy group, 6.3 months in the group treated with radiotherapy, and 2.6 months in the Bleomycin treated group. The authors concluded that the combination of Bleomycin and radiotherapy seems to be a further step in palliative treatment of advanced esophageal cancer.

Adult↗
PubMedDate not supplied

High doses of 5-fluorouracil and epirubicin with or without cisplatin in advanced gastric cancer: a randomized study.

BACKGROUND: A prospective randomized clinical study was performed in patients with locally advanced or metastatic gastric cancer. The purpose of the study was to determine the activity of high doses of 5-fluorouracil and epirubicin (FE) vs. the same combination + cisplatin (FEP), and particularly the value of cisplatin in the combination. PATIENTS AND METHODS: A total of 122 patients was included in the study; 110 of them were assessable. In the FE arm, the treatment involved 1000 mg/m2 in a 6-hr infusion of 5-fluorouracil on days 1, 2, 3, 4 and 5 and 120 mg/m2 of epirubicin i.v. on day 1. In the FEP arm, the same combination of cytostatics + cisplatin (30 mg/m2) was administered on days 2 and 4. The cycles were repeated after 4 weeks. Altogether, 468 cycles of chemotherapy were given (FE, 240; FEP, 228). RESULTS: In the FE arm, 56 patients were assessable, with 2 complete and 14 partial remissions (28.6%); in the FEP arm, 4 complete and 19 partial remissions (42.6%) were observed in 54 assessable patients. Median survival in the FE group was 7.1 months and in the FEP group 9.6 months. The survival difference was statistically significant (Cox's test, P<0.05). The most frequent side effects included grade 2 and 3 alopecia (FE, 93%; FEP, 94%) and grade 2 and 3 vomiting (FE, 20%; FEP, 35%). Grade 3 and 4 leukopenia was observed in 9% of patients in the FE group and in 13% of patients in the FEP group, with 6 cases of febrile neutropenia (FE, 4%; FEP, 7%). Stenocardia was registered in 1 patient in the FE group and in 2 patients in the FEP group. No treatment-related death was registered. CONCLUSIONS: The addition of cisplatin to high doses of 5-fluorouracil and epirubicin resulted in a statistically significant better survival of treated patients.

Antibiotics, Antineoplastic↗
PubMedDate not supplied

Evidence for uptake of plamid DNA into intact plants (Lemna perpusilla) proved by an E. coli transformation assay.

The water plant Lemna perpusilla has been incubated with the E. coli plasmids pMB9 and pBR325, respectively. Uptake of plasmids has been shown by subsequent transformation of E. coli cells to tetracycline resistance after treatment with Lemna DNA from plasmid-incubated plants. In 7 out of 15 assays we found stable transformants. From the transformation rate an amount of 10(-4) to 10(-6) micrograms plasmid DNA per 10 micrograms of plant DNA can be calculated.

DNA, Recombinant↗