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Biomedical subjects

A Rosengren

Publications and source records attributed to A Rosengren.

At least 91 records · Page 5Linked to original sources
PubMed1994

Method for immunolocalization of extracellular proteins in association with the implant-soft tissue interface.

A method allowing immunolocalization of macromolecules surrounding biomaterial implants has been developed. Plugs of pure titanium were inserted into the abdominal wall of rats. One week after implantation plugs with adjacent tissue were gently fixed and cryoprotected before being rapidly frozen in LN2-cooled propane, followed by cryosubstitution, using methanol, and low temperature infiltration and UV curing of the methacrylate LR-Gold. Before sectioning, bulk metal was removed electrochemically, leaving the surface oxide intact, appearing in sections as a dense line in contact with the tissue. Postembedding immunolocalization for rat albumin, IgG, C3c, fibrinogen and fibronectin was performed at the light and electron microscopic levels. Our observations indicate that 1 wk after implant insertion, a network of fibrin and fibronectin decorates the tissue surface that faces the implant, but without any obvious concentration to the implant surface.

Abdominal Muscles↗
PubMed1993

Stressful life events, social support, and mortality in men born in 1933.

OBJECTIVE: To examine relations between stressful life events and mortality in middle aged men. DESIGN: Prospective population study. Data on stressful life events, social network, occupation, and other psychosocial factors derived from self administered questionnaires. Mortality data obtained from official registers. SETTING: City of Gothenburg, Sweden. SUBJECTS: 752 men from a random population sample of 1016 men aged 50. MAIN OUTCOME MEASURE: Mortality from all causes during seven years' follow up. RESULTS: Life events which had occurred in the year before the baseline examination were significantly associated with mortality from all causes during seven years' follow up. Of the men who had experienced three or more events during the past year 10.9% had died compared with 3.3% among those with no life events (odds ratio 3.6; 95% confidence interval 1.5 to 8.5). The association between recent life events and mortality remained true after smoking, self perceived health, occupational class, and indices of social support were controlled for. Many of the deaths were alcohol related, but the number of deaths was too small to allow for analyses of specific causes of death. The association between life events and mortality was evident only in men with low emotional support. CONCLUSION: Stressful life events are associated with high mortality in middle aged men. Men with adequate emotional support seem to be protected.

Cause of Death↗
PubMed1993

Low systolic blood pressure and self perceived wellbeing in middle aged men.

OBJECTIVE: To examine the relation between systolic blood pressure and self perceived wellbeing in 50 year old men. DESIGN: Cross sectional population study of data derived from questionnaires and physical examination as a part of a cardiovascular risk factor survey. SETTING: City of Gothenburg, Sweden. STUDY POPULATION: 776 men from a random population sample of 1016 men aged 50. METHODS: Self perceived wellbeing according to the Gothenburg quality of life questionnaire, which is an assessment of social, physical, and mental wellbeing in 15 different areas. MAIN RESULTS: Low systolic blood pressure was significantly (p < 0.05) related to impaired social wellbeing in four areas: work, home and family, financial situation, and housing. Of the items dealing with physical wellbeing, health, memory, and appetite were significantly related to blood pressure. As regards mental wellbeing, energy and self confidence were significantly related to systolic blood pressure. Diastolic blood pressure was significantly related to housing, memory, energy, patience, and self confidence. In multiple regression analyses that controlled for smoking, stress, physical activity, social activity, and emotional support, poor social, physical, and mental wellbeing were all significantly related to low systolic blood pressure independently of other factors. Low diastolic blood pressure was independently associated with poor physical and mental, but not social, wellbeing. CONCLUSION: Low systolic blood pressure was associated with poor perception of wellbeing in several areas. The cause is unclear.

Attitude to Health↗
PubMed1993

Multiple insulin injection therapy using an insulin pen--who benefits? A clinical 3-year follow-up study of 100 type 1 and 51 type 2 diabetic patients.

The present study was undertaken with the aim of evaluating the effect of multiple insulin injection therapy with an insulin pen in a large population of type 1 and type 2 diabetes patients and to investigate which factors predict a favorable response to the therapy change. We included 100 type 1 and 51 type 2 patients with a minimum diabetes duration of 1 year who were followed for at least 3 years after changing from conventional insulin regimens to multiple insulin injection therapy with the pen. Both type 1 and type 2 patients were significantly improved with respect to metabolic control at 3 months. After 1 year type 1 patients were no longer significantly improved compared to baseline. In type 2 patients a significant improvement was sustained for a longer period but at 3 years HbA1c had reverted towards the baseline level. Both type 1 and type 2 patients experienced a significant increase in body weight. Baseline metabolic control was strongly and inversely related to subsequent decline in HbA1c in both type 1 and type 2 patients. Those with initial poor control had a sustained improvement throughout follow-up, whereas those with initial very good control deteriorated significantly. No sustained change was noted in those in intermediate control. In addition, in type 1 patients a high body mass index at baseline was a weak negative predictor for improvement. In type 2 patients a longer duration of diabetes was a favorable factor. Both type 1 and 2 patients in poor control may be expected to benefit from multiple injection therapy.

Adult↗
PubMed1992

Coronary heart disease, cancer and mortality in male middle-aged light smokers.

We examined the effect of light smoking in relation to incidence of coronary heart disease (CHD) in a general population sample consisting of 6879 men aged 47-55 years and free of previous myocardial infarction (MI) at baseline. After a follow-up of mean duration 11.8 years, 11.0% of men smoking 1-4 cigarettes daily (n = 228) had suffered a major CHD event, compared to 3.7% of non-smokers (n = 2049) [adjusted odds ratio 2.8 (1.7-4.7)]. No further increase in risk was observed in men who smoked more. There was an increasing risk of death from cancer with the number of cigarettes smoked per day. Mortality was increased in all categories of cigarette smokers, particularly among the very heavy smokers, who had a mortality risk of 22% compared to 6% among nonsmokers [adjusted odds ratio 4.4 (2.7-7.1)]. Data from an examination 4 years later considered only those men who stated that their smoking habits were identical on both occasions (n = 3981). Among these subjects the incidence of CHD after a mean period of 7.1 years was 10.6% in men smoking 1-4 cigarettes per day, compared to 2.6% in nonsmokers [adjusted O.R. 4.6 (2.1-10.1)]. No dose-response effect was observed. Even very light cigarette smoking considerably increases the risk of CHD in middle-aged men.

Cause of Death↗
PubMed1991

Self-perceived psychological stress and incidence of coronary artery disease in middle-aged men.

Self-perceived psychological stress as a risk factor for coronary artery disease (CAD) was evaluated in a general population study comprising 6,935 men aged 47 to 55 years at baseline without previous myocardial infarction. In 1970 to 1973, the men answered a question about psychological stress defined as a feeling of tension, irritability or anxiety, or as having sleeping difficulties as a result of conditions at work or at home. Psychological stress was graded as follows: (1) never experienced stress; (2) greater than or equal to 1 period of stress; (3) greater than or equal to 1 period of stress during the last 5 years; (4) several periods of stress during the last 5 years; and (5 to 6) permanent stress during the last year or the last 5 years. After a mean follow-up of 11.8 years, 6% of the men with the lowest 4 stress ratings (n = 5,865) had either developed a nonfatal myocardial infarction or died from CAD, with no increase in risk from grade 1 to 4. The corresponding figure among the men with the highest 2 stress ratings (n = 1,070) was 10%; the odds ratio was 1.5 (95% confidence interval 1.2-1.9) after controlling for age and other risk factors. Similar, independent associations were seen with stroke, and with death from cardiovascular disease and from all causes, but not with death from cancer. With respect to CAD, no decrease in the effect of stress at baseline could be seen over time. No relation between life events and self-perceived psychological stress was found in another sample of 732 fifty-year-old men.

Cause of Death↗