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Biomedical subjects

A Rosengren

Publications and source records attributed to A Rosengren.

At least 73 records · Page 4Linked to original sources
PubMed1997

Inflammatory reaction dependence on implant localization in rat soft tissue models.

This study compares two different implantation models in soft tissue in rat abdominal wall with regard to inflammatory reactions. Titanium rods and discs, penetrating or not penetrating the peritoneal wall respectively, were implanted. After 3, 10 or 30 days the distribution of monocytes/macrophages and cytokines (interleukin-1 and transforming growth factor-beta) in the tissue adjacent to the implants was investigated under immunohistochemistry. The macrophage-specific antibody, ED1, was used for the identification of newly recruited macrophages and the ED2 antibody was used for the mature tissue macrophages. After 10 days the non-penetrating implants had a larger number of cells close to the implant than the penetrating implants. The opposite was seen after 30 days implantation, with a larger number of cells around the penetrating implants. At all time intervals the penetrating implants had a thicker reactive capsule. The cytokines interleukin-1beta and transforming growth factor-beta could be detected in the reactive tissue adjacent to both types of implants, without obvious differences for the two implant situations. The biocompatibility of a material appears to be influenced by the localization of the implant. In addition, it seems to be of importance to extend the follow-up periods further, as we cannot assume that steady state is reached at 30 days implantation.

Abdominal Muscles↗
PubMed1997

Physical activity protects against coronary death and deaths from all causes in middle-aged men. Evidence from a 20-year follow-up of the primary prevention study in Göteborg.

We set out to examine the long-term effect of work-related and leisure time physical activity on risk of death from coronary heart disease (CHD) and other causes. Data were obtained from a large prospective population study of 7142 participant men aged 47 to 55 years at baseline in 1970-1973 and without symptomatic CHD. Data on physical activity at work and at leisure were assessed by way of a questionnaire. After 20 years follow-up men with physically demanding work had a slightly higher mortality from all causes, but not from CHD. The association with all-cause mortality disappeared after controlling for smoking, occupational class, and alcohol abuse. Men who were physically active during leisure time had a lower risk of death from CHD, cancer, and all causes. After controlling for smoking, diastolic blood pressure, serum cholesterol, body mass index, diabetes alcohol abuse, and low occupational class, the most active men had a relative risk (RR) of dying from CHD of 0.72 (0.56-0.92 95% CI) and of all causes of 0.70 (0.61-0.80 95% CI). The adjusted relative risk for cancer death was of borderline significance. Noncardiovascular deaths other than cancer showed a strong relationship with low physical activity in the present study that remained after controlling for smoking, alcohol abuse, and other factors (adjusted RR 0.55 (0.42-0.73 95% CI)). The protective effect of CHD and on mortality was present after excluding the first 8 years of follow-up, and at all levels of other risk factors, such as smoking, diastolic blood pressure, serum cholesterol, and body mass index. In conclusion, this long-term study demonstrates the protective effect of leisure time physical activity on CHD death, cancer death, and on death from all causes. The effect on coronary death and on death from all causes was independent of other risk factors.

Aged↗
PubMed1997

Risk factors for cardiovascular disease during the period 1985-1995 in Göteborg, Sweden. The GOT-MONICA Project.

AIMS: To report levels of cardiovascular risk factors in 1985, 1990 and 1995 in three population samples in Göteborg, Sweden, and to compare with previous population risk factor levels. POPULATION: The study was performed within the framework of the WHO MONICA Project which compares risk factor levels as well as the incidence of coronary heart disease and stroke in 38 populations. METHODS: Three random samples of men and women aged 25-34, 35-44, 45-54 and 55-64 comprising 152-218 subjects in each age group who responded to the invitation for screening procedures which included questionnaires, physical and laboratory investigations in 1985, 1990 and 1995. RESULTS: More men than women had smoked, except for those aged 35-44 where there was no difference between men and women. The proportion of men who had smoked decreased strongly between the first and third investigations (P < 0.0001), particularly amongst the younger age-groups, with a similar tendency amongst women. In the 25-44-years age group there was a tendency towards more women than men to be smokers in 1995. Snuff was used by 27% and 19% of men aged 25-34 and 35-44 years, respectively, in 1995. Up to 5% of women used snuff; higher in the younger age groups. More young men than women reported regular physical activity during leisure time with a tendency towards an increase from 1985 to 1995. The proportion of men reporting psychological stress varied little over the study period, but women aged 25-34 reported increased stress from 1985 to 1995. Body weight increased whereas height remained stable and consequently body mass index increased in men and women (P = 0.0001). Similarly, waist:hip ratio (measured in 1990 and 1995 only) also increased (P = 0.0001). Mean systolic and diastolic blood pressure increased with age and there was also a small increase between 1985 and 1995. Systolic blood pressure increased by a mean of 1.24 mmHg per 5-year period independent of sex and age (P = 0.0001). Antihypertensive treatment increased with age, but was stable between 1985 and 1995. Serum total and LDL cholesterol concentrations increased with age, and there was a nonsignificant tendency also to higher HDL cholesterol concentrations at older ages. Serum total cholesterol concentration declined between 1985 and 1995, and HDL cholesterol declined significantly between 1985 and 1995 in all age groups for men and women only when all age groups were analysed together. Similar to total cholesterol, levels of LDL cholesterol declined between 1985 and 1995 for all ages. Serum triglyceride levels increased for men and women between 1985 and 1995.

Adult↗
PubMed1997

Coronary heart disease attack rate, incidence and mortality 1975-1994 in Göteborg, Sweden.

MATERIAL AND METHODS: Data from the Göteborg myocardial infarction register were used to investigate trends in attack rate, incidence of non-fatal myocardial infarction and mortality from coronary heart disease in persons aged 64 and below during the period 1975-1994. RESULTS: Myocardial infarction was defined according to strict criteria which remained the same throughout the study period. Attack rate and incidence were 3-5 times higher among men than women. The ratio of recurrent infarcts out of all attacks increased with increasing age and was 14%, 20% and 24% for men aged 35-44, 45-54, and 55-64, respectively. Corresponding rates for women were 8%, 14%, and 22%, respectively. Both attack rate and incidence decreased significantly by 2.1-3.9% per year during the study period for most age groups. The 28-day fatality rate (hospitalized as well as non-hospitalized cases) tended to decline, but significantly so only in the oldest men. The same was true for 28-day fatality among hospitalized patients. The majority of all coronary heart disease deaths occurred outside hospital in people unaware they had coronary heart disease. Mortality from coronary heart disease decreased by 2.0-6.8% per year during the study period. In-hospital treatment of myocardial infarction with intravenous beta-blockers followed by oral treatment, nitroglycerin and thrombolytics increased during the study period. Coronary surgery and angioplasty were used in less than 5% of patients during the study period, but increased substantially in 1994. CONCLUSION: Coronary heart disease and mortality in ages below 65 years are now decreasing in Sweden. Decreasing short-term mortality is almost certainly due to more efficient treatment in hospital, but as the majority of coronary heart disease deaths occur outside hospital and in people unaware they have coronary heart disease, primary prevention is still very important.

Adult↗
PubMed1997

Serum cholesterol and long-term prognosis in middle-aged men with myocardial infarction and angina pectoris. A 16-year follow-up of the Primary Prevention Study in Göteborg, Sweden.

OBJECTIVE: To compare the role of serum cholesterol in the long-term prognosis of men with a history of myocardial infarction, in men with clinical angina without myocardial infarction, and men without clinical coronary disease. METHODS: In the second screening of the Primary Prevention Study in Göteborg which comprised 7100 men aged 51 to 59 years at baseline in 1974-1977, 314 men with clinical angina but no myocardial infarction at baseline were identified and 195 men who had survived a myocardial infarction for 0 to 19 years (median 3 years). RESULTS: Of the men without clinical coronary disease at baseline and cholesterol at or below 5.2 mmol.l-1, 2.7 per 1000 observation years died from coronary disease compared to 8.5 per 1000 of the men with serum cholesterol of 7.2 mmol.l-1 or more. Corresponding figures for men with angina was 5.5 and 31.0 per 1000 observation years, and for men with prior myocardial infarction 19.8 and 58.3, respectively, per 1000. After adjustment for age, smoking, systolic blood pressure, body mass index and diabetes the risk of coronary death in men with serum cholesterol above 7.2 mmol.l-1 compared to below 5.2 mmol.l-1 was 2.42 (1.66-3.51) in healthy men, 4.82 (1.44-16.09) in men with angina, 2.70 (0.95-7.67) in survivors of myocardial infarction, and 4.07 (1.86-8.91) in the combined group of men with either angina or prior infarction. The strongest effect was seen during the first half of the follow-up, with an adjusted relative risk for high in relation to low serum cholesterol of 8.08 (1.95-33.55) in men with preexisting coronary disease. Non-coronary deaths varied little by serum cholesterol or coronary disease status at baseline. After 16 years, 76% of the healthy men with low cholesterol and 65% of healthy men with cholesterol above 7.2 mmol.l-1 were still alive. Of the men with prior myocardial infarction, 50% in the group with low cholesterol were alive after 16 years, as compared to 21% of those with high cholesterol. CONCLUSION: The long-term absolute risk of death in men with coronary disease and elevated serum cholesterol is very high. Implementation of lipid-lowering strategies shown to be efficacious is important in this high-risk group.

Angina Pectoris↗
PubMed1996

Immunohistochemical studies on the distribution of albumin, fibrinogen, fibronectin, IgG and collagen around PTFE and titanium implants.

Time-dependent distribution of extracellular proteins (albumin, fibrinogen, fibronectin, collagen-I and IgG) in the interface zone between implant and soft tissue has been investigated utilizing a recently developed method. Commercially pure (c.p.) titanium and polytetrafluoroethylene (PTFE) implants were inserted in the abdominal wall of rats for 1, 6 and 12 weeks followed by a mild fixation, cryoprotection, rapid freezing in LN2-cooled propane, cryosubstitution and low-temperature infiltration with UV curing of the methacrylate LR-Gold. Before sectioning, the bulk part of the titanium was removed by an electrolytical dissolution technique (electropolishing), while the PTFE implants were removed by a fracture technique. Employing a cryosubstitution method combined with postembedding immunohistochemistry, a light microscopic analysis was allowed. The selected proteins had an apparently varying distribution in the implant-close tissue and their distribution changed during the follow-up period. There was also a difference in the distribution pattern for each protein around titanium and PTFE implants. Insertion of the c.p. titanium implants elicited an inflammatory reaction in many respects similar to a normal wound healing response, while the PTFE implants caused a more pronounced, persistent inflammation.

Abdominal Muscles↗
PubMed1996

Essential fatty acids and abnormal involuntary movements in the general male population: a study of men born in 1933.

Spontaneous and tardive dyskinesias were studied in a random population sample of 446 men, aged 59 years. Dyskinesia, defined as an AIMS score of at least 2 in any body part, was seen in 15.1% (n = 74). Dyskinetic men had a higher cigarette consumption, and they had higher frequencies of psychiatric morbidity and exposure to neuroleptics. Dyskinesia was also associated with several abnormalities in EFA concentrations in plasma, but the most consistent finding was the low arachidonic acid levels in phospholipids, triglycerides and cholesterol esters. In a logistic regression model, cigarette consumption (P < 0.02), exposure to neuroleptics (P < 0.01), and low arachidonic acid levels in the phospholipid fraction (P < 0.0001) were independently associated with dyskinesia.

Antipsychotic Agents↗
PubMed1996

Fibrinogen, coronary heart disease and mortality from all causes in smokers and nonsmokers. The study of men born in 1933.

OBJECTIVES: To analyse the relation between fibrinogen concentration and incidence of coronary heart disease and mortality from all causes. A secondary aim was to investigate whether the effect of fibrinogen, as in previous cross-sectional analyses from this population, was restricted to nonsmokers. DESIGN: Prospective population study. SETTING: City of Göteborg, Sweden. SUBJECTS: A total of 664 men from a population sample of 1016 men aged 50 in 1983, without prior myocardial infarction. MAIN OUTCOME MEASURES: Development of coronary heart disease (myocardial infarction, coronary death or, in men with angina, revascularization, or scintigraphic evidence of coronary disease) and death from all causes, in relation to fibrinogen concentration and smoking status at baseline, during 9 years' follow-up. RESULTS: Rates of coronary heart disease during follow-up in the lowest, middle and highest third of the fibrinogen distribution were 4.6, 6.4 and 10.3%, respectively, but this did not remain significant after controlling for smoking and other risk factors (adjusted odds ratio [OR] for the highest, compared to the lowest third 1.5 [0.7-3.4]). Percentages of men who died from any cause were 3.2, 5.9 and 10.7 in the lowest, middle and highest thirds of fibrinogen, respectively. After adjustment for smoking and other risk factors, this difference remained significant (relative risk 2.6 [1.2-5.9]). In men who were smokers at baseline, fibrinogen was not significantly related to coronary heart disease or mortality. Men who did not smoke in the lowest, middle, and highest third of the fibrinogen distribution had rates of coronary heart disease of 1.8, 3.6 and 10.3%, respectively, and of deaths from all causes of 1.8, 2.9 and 8.4%, respectively. The adjusted OR remained significant at 5.4 (1.4-20.0) for coronary heart disease, as did the adjusted relative risk for mortality at 3.8 (1.01-14.4). CONCLUSION: Plasma fibrinogen is an independent predictor of premature death, and also of coronary heart disease, in middle-aged men and in nonsmokers. A high fibrinogen concentration, particularly in a nonsmoker, deserves attention.

Cause of Death↗
PubMed1996

Is hypertension changing? Blood pressure development in cohorts of 50-year-old men between 1963 and 1993.

OBJECTIVE: To study secular trends in the prevalence and treatment of hypertension in the general population, and the disease course. DESIGN: Health examinations of cohorts of 50-year-old men in 1963, 1973, 1983 and 1993. SETTING: The city of Göteborg, Sweden (about 400,000 inhabitants). PARTICIPANTS: Random population samples of 50-year-old men. MAIN OUTCOME MEASURE: Mean blood pressure (BP) levels in the populations and among treated hypertensives, proportions of hypertensives, and frequency of high BP values (> or = 160/and or 95, and > or = 175/115 mmHg, respectively). RESULTS: The mean population BP decreased from 138.4/89.0 mm to 128.7/84.4 mmHg during the 30-year period (p < 0.0001). Mean BP levels among treated hypertensives decreased from 170/113 to 142/94 mmHg (p < 0.0001), and the proportion of men with high BP values diminished from 3.9 to 0.1%. Also BP levels among normotensives decreased significantly (p < 0.0001). CONCLUSION: The findings could partly be seen as a result of successful case-finding and treatment of hypertension in the region, but alteration of the natural course of hypertension cannot be excluded.

Blood Pressure↗
PubMed1996

Social relationships and myocardial infarction: a case-control study.

BACKGROUND: For more than 10 years there has been increasing evidence that not only biological risk factors are important for the development of coronary heart disease. The present study is one of a series of case-control studies in which a wide range of psychosocial factors in the same population have been analysed to obtain information on their relationship with myocardial infarction, and of the interaction between psychosocial and biomedical variables. METHODS: The association between social relationships and nonfatal myocardial infarction was studied by comparing consecutively admitted male (n = 288) and female (n = 55) patients with myocardial infarction with a population sample of 283 men and 129 women. All participants were under 65 years of age. The social relationships were investigated by means of a self-administered questionnaire. RESULTS: Men with myocardial infarction reported significantly lower perceived emotional support compared with their controls, as well as less social activity. Women with myocardial infarction reported significantly less social activity than their controls. There were no significant differences between cases and controls in social integration (number and frequency of social relationships and contacts). Neither did dissatisfaction with social relationships differ significantly between patients with myocardial infarction and controls. After controlling for traditional risk factors (smoking, hypertension, serum cholesterol level, diabetes) perceived emotional support remained significantly related to myocardial infarction in men, and so did the amount of social activity in both men and women. CONCLUSION: The importance of perceived emotional support and lack of social activity is amplified by the fact that they are related to myocardial infarction independently of conventional biomedical risk factors. These social factors should be studied further in prospective investigations.

Adult↗
PubMed1995

Behavioural characteristics in patients with myocardial infarction: a case-control study.

BACKGROUND: Over the past 10-20 years, evidence has accumulated suggesting that it is not just biological risk factors that are important for the development of coronary heart disease. The present study is one of a series of case-control studies in which a wide range of psychosocial factors have been analysed in the same population to obtain information on their relationship with myocardial infarction, as well as of the interaction between psychosocial and biomedical variables. METHODS: The relationship between behavioural factors and non-fatal myocardial infarction was studied by comparing consecutively admitted male (n = 288) and female (n = 55) patients with a population sample of 283 men and 129 women. All participants were under 65 years of age. The behavioural variables (type-A behaviour, health locus of control, sleep problems and alcohol consumption) were investigated by means of a self-administered questionnaire. RESULTS: No significant differences emerged between patients with myocardial infarction and controls in terms of their type-A behaviour pattern. After controlling for traditional risk factors (smoking, hypertension, serum cholesterol level and diabetes), men with myocardial infarction reported a significantly stronger external health locus of control (i.e. a weak belief in their capacity to control their health) compared with their controls, as well as more problems with sleep and a lower alcohol consumption; women with myocardial infarction reported significantly more problems with sleep than their controls. CONCLUSION: The importance of health locus of control, sleep problems and alcohol consumption is amplified by the fact that they are related to myocardial infarction independently of conventional biomedical risk factors. These behavioural factors should be studied further in prospective investigations.

Adult↗