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Biomedical subjects

A Rohner

Publications and source records attributed to A Rohner.

At least 145 records · Page 8Linked to original sources
PubMed1984

[Application of computerized tomoscintigraphy in the detection of tumors using cobalt-57-marked bleomycin].

57Co-bleomycin scanning dates from the early 1970s, when the first results were presented by Renault et al. Since then there have been numerous publications concerning the high sensitivity of this type of study in the detection of pulmonary or cerebral neoplasms. In the region below the diaphragm, however, sensitivity was poor due to hyperactivity of the kidney, liver and bladder. To eliminate this problem the authors have used single photon emission computerized tomography (SPECT), and their department is currently investigating the sensitivity of this technique for the detection of neoplasms. Two typical cases are described which illustrate the value of this method in the detection of cancer.

Abdominal Neoplasms↗
PubMed1984

[25 cases of gastric smooth muscle tumors and review of the literature].

25 gastric smooth muscle tumors (12 symptomatic leiomyomas, 9 fortuitously discovered leiomyomas and 4 leiomyosarcomas) are presented. Follow-up has lasted from 9 months to 9 years. We have correlated the epidemiology, symptoms and anatomopathology with the evolution of these cases, in an attempt to single out specific features of benign and malignant forms. The most relevant macroscopic criteria of malignity are: a tumor measuring over 5 cm in diameter, widespread intratumoral necrosis. The histologic degree of malignity depends on several criteria, of which the most important are: the number of mitoses per high power microscopic field, cellular pleomorphism. Barium meal detects all symptomatic gastric smooth muscle tumors, and echography has the advantage of objectivizing intratumoral necrosis. For benign as well as malignant tumors the excision should be minimal, leaving a 2 cm safety margin. Simple enucleation is ruled out. If possible, metastases should be removed with the same safety margin. There is a good correlation between histologic type and prognosis. One case in 4 is associated with another malignancy.

Humans↗
PubMed1984

[Late results of total colectomies for inflammatory colitis].

A retrospective study of 41 patients colectomized for inflammatory colitis has been conducted with a mean follow-up of 90 months. The results of rectum preservation and of ileo-rectal anastomoses were disappointing, with a respective success rate of 15% and 44%. 15% of patients had a change of diagnosis after colectomy, all in favour of undetected Crohn's disease. The results of mucosal proctectomy with ileoanal anastomosis are highly encouraging. An attempt is made to specify the indications for each type of surgery.

Adult↗
PubMed1984

[Percutaneous drainage of intra-abdominal fluid collections using computed tomography].

Percutaneous catheter drainage guided by computed tomography has been used to treat 45 intraabdominal collections in 32 patients. The 45 drainages involved 15 pancreatic cysts of chronic pancreatitis, 15 spontaneous abscesses and 15 postoperative abscesses. The collections were treated either by one puncture only or by drainage, with a success rate of 87.5%. Morbidity was 2.2% (one right empyema after puncture of a postoperative right subphrenic abscess). Mortality was nil. Three inadequate drainages due to enteric communication required secondary surgery. It is concluded that, if the indications are correct, percutaneous drainage guided by CT is as good as surgery and involves lower morbidity and mortality.

Abdomen↗
PubMed1984

[Surgery of non-malignant disorders of the cecum].

In a total series of 207 complete or partial cecal resections during the last 6 years, 132 cecal lesions were found. 64 of the lesions were malignant and 68 benign. In the same period 2657 appendicectomies were performed. Histological analysis of the resected nonmalignant cecal lesions (partial cecectomy , ileocecectomy , right hemicolectomy and total colectomy) revealed ulcerative colitis in 25%, Crohn's disease in 20%, inflammatory pseudotumor in 15%, familial polyposis in 11%, benign tumors in 15% and various rare affections in 15%. From the topographical point of view one third of the lesions mainly involved the cecum, one third all of the colon, 20% the ileocecal area and 10% originated from the appendix vermiformis. The fact that the benign cecal lesions are probably as frequent as malignant cecal lesions shows that importance of good preoperative investigations in order to establish optimum surgical tactics and to prevent functional sequelae as a result of too generous resections. Therefore, histological analysis before or during surgery is of prime importance.

Adult↗
PubMed1984

Pancreatic cystadenoma and cystadenocarcinoma.

Cystadenomas and cystadenocarcinomas are rare but not exceptional tumours of the pancreas. In this report six cases are added to the more than 300 cystadenomas and over 100 cystadenocarcinomas reported in the literature. We present here the case histories of four cystadenomas and two cystadenocarcinomas with complete follow-up. There is no evidence of recurrence after a maximum of 22 years in cystadenoma and 4 years in cystadenocarcinoma following resection. We have the impression that cystic lesions of the pancreas are nowadays more often detected than in former years. This might be due to abdominal investigation by computerized tomography and ultrasound on a large scale. Pathological features of proliferative cystic lesions of the pancreas permit distinction of three different tumours: serous cystadenoma, mucinous cystadenoma and cystadenocarcinoma. The serous cystadenoma is benign. The mucinous cystadenoma has to be considered as potentially malignant. The cystadenocarcinoma is malignant by definition. As benign and malignant elements can be found in the same cyst biopsy cannot exclude cystadenocarcinoma. Therefore all cystadenomas and cystadenocarcinomas should be totally excised, especially as prognosis after resection of cystadenocarcinoma is much better than after resection of adenocarcinoma of the pancreas.

Adult↗
PubMed1983

Determination of pancreatic carboxypeptidase A in human blood serum.

A method has been designed for the assay of pancreatic carboxypeptidase A in blood serum. It uses Z-Gly-Phe as the substrate and fluorimetric determination of the released phenylalanine in an amino acid analyser, which yields a measure of free carboxypeptidase A. In addition, the sum (free carboxypeptidase A + procarboxypeptidase A) can be determined on a second portion preincubated with trypsin, which converts the proenzyme to the active form. Determinations made in fifteen healthy individuals showed the presence of a measurable concentration of free carboxypeptidase A. In acute pancreatitis, total carboxypeptidase A is raised. An increase in circulating proenzyme is observed in some cases. Data from 46 patients show a good correlation between total carboxypeptidase A, lipase and immunoreactive trypsin. Differential determination of procarboxypeptidase A and free carboxypeptidase A provides an interesting new tool for the diagnosis of pancreatic disorders.

Acute Disease↗
PubMed1983

[Inflammatory fibroid polyps of the digestive tract. Apropos of 5 cases].

Inflammatory fibroid polyp (IFP) is an infrequent condition of the digestive tract which is most often observed in the gastric antrum and ileum. It is known by several synonyms (Vanek tumour, eosinophilic granuloma, etc.) and is sometimes mistaken for eosinophilic gastroenteritis. Its main clinical features are abdominal pain, ulcer-like syndrome, obstruction and/or haemorrhage. It usually runs a benign course and surgery remains the treatment of choice. Its aetiology is unknown. Five cases of gastric IFP are described, one of which was diagnosed from endoscopic biopsies before resection. This is a very uncommon feature which, to our knowledge, has not previously been reported in the literature.

Adult↗
PubMed1983

[Appendicular invagination and post-appendectomy invagination].

Intussusception of the appendix is an uncommon event (200 cases previously reported) and intussusception after appendicectomy is rare (20 cases previously published). Two recent cases are reported, the first with primary appendiceal intussusception and the second ileocolic intussusception after appendicectomy. In the second case the final pathology report revealed an intussuscepted caecal duplication responsible for the ileocolic intussusception. This event has not been previously reported. Symptomatology, investigation, classification, differential diagnosis and surgical tactics are discussed.

Adolescent↗