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Biomedical subjects

A Ricci

Publications and source records attributed to A Ricci.

At least 307 records · Page 17Linked to original sources
PubMed1975

[Surgical repair of chronic instabilities of the cruciate ligaments of the knee].

The authors have developped a technique aiming at replacing the anterior cruciate ligament by the tendon of gracilis muscle derouted through the intercondylar region and acting as an active transplant in 32 cases. In 20 other cases replacement of the posterior cruciate ligament was obtained by the use of the tendon of semi tendinosus muscle acting as a passive neo-ligament. The follow-up study demonstrated 87 p. 100 of good results after isolated tears of the anterior ligament and 83 p. 100 after isolated tears of the posterior ligament. 21 times an additional plasty of the medial ligament had to be performed. In these combined lesions results were less favourable.

Elasticity↗
PubMed1974

Experiments with cholera toxin detoxified with glutaraldehyde.

Studies on the production, purification, and detoxification of cholera toxin are reported. The toxin was first partially purified with aluminium hydroxide and further purification was effected with Bio Gel A-5m and Sephadex G-75. The toxins were detoxified with glutaraldehyde; the toxoids so obtained, when injected into the skin of rabbits, appeared to have no residual toxicity. All the toxins were immunogenic. The toxoid partially purified with aluminium hydroxide retained most of its immunizing capacity, but the highly purified toxoids did not retain their capacity to stimulate antibody production in rabbits.

Aldehydes↗
PubMed1974

Experiments on monkeys with cholera toxin partially purified and detoxified with formol and glycine.

Cholera toxoid partially purified and detoxified with formol and glycine and inoculated in monkeys proved safe. Histological examination revealed no changes in the skin of the animals treated. Blood samples taken from monkeys immunized with 2 doses of toxoid 12 days after the second inoculation revealed appreciable levels of antitoxin in the animals that had received two 100-mug doses of toxoid. The monkeys vaccinated with toxoid, when inoculated with challenge doses of cholera toxin, had the capacity to neutralize the toxin. Detoxification with formol and glycine may be the first step towards the preparation of a highly purified, innocuous, and antigenic cholera toxoid.

Animals↗