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Biomedical subjects

A Rees

Publications and source records attributed to A Rees.

180 records · Page 10Linked to original sources
PubMed1981

Detecting ductal shunting in premature infants by range-gated Doppler echocardiography.

Range-gated pulsed Doppler echocardiography has been reported to be a useful noninvasive bedside technic for detecting ductal left-to-right shunting in premature infants. We studied 30 premature infants with a birth weight of less than 1,500 gm, using a 5 MHz system developed by Advanced Technology Laboratories. An umbilical artery catheter was used to obtain a contrast aortogram. Twenty-three infants had both a positive flush aortogram and a continuous turbulence documented by Doppler echocardiography. A clinically audible murmur was present in 17 of these patients. In six infants there was no Doppler evidence of PDA. In five of this last group there was also a negative flush aortogram. The excellent correlation found between the Doppler and aortographic studies suggests that this noninvasive technic is very sensitive for detecting ductal left-to-right shunting, even in the absence of an audible murmur.

Aortography↗
PubMed1981

Induction of human antigen-specific suppressor factors in vitro.

Based on methods used for the in vitro induction of antigen-specific suppressor cells in the mouse, we have cultured Ficoll-Isopaque-separated human blood cells with high dose of antigen (100 microgram/ml) in Marbrook culture vessels for 4 days. The resulting cells, when further recultured for 24 hr with a low dose of antigen (1 microgram/ml), released into the supernatant material, termed 'suppressor factor', which inhibited, in an antigen-specific manner, the antibody response of mouse spleen cells in culture. The suppressor factor was analysed using immunoabsorbents, and was bound to and eluted from specific antigen, concanavalin A and lentil lectin, anti-human Ia antibodies, and anti-mouse suppressor factor antibodies, but was not bound to antibodies against human IgG.

Antigens↗
PubMed1981

Genetics of human T cell-monocyte interaction in helper cell induction.

The generation of human antigen-specific helper cells from unprimed peripheral blood lymphoid cells in tissue culture requires the presence of the appropriate number of blood monocytes. The role of the HLA complex in this cell interaction was investigated, by using HLA-type donors, and it was found that the monocytes had to share at least one HLA-DR specificity with the T cell donor. These experiments suggested that the genes controlling the macrophage-T cell interaction are closely associated or in linkage disequilibrium with the HLA-DR region.

Animals↗
PubMed1976

Echocardiographic evidence of outflow tract obstruction in Pompe's disease (glycogen storage disease of the heart).

A 7 month old black female infant with the clinical findings of Pompe's disease is presented. The diagnosis of an infiltrative myocardiopathy with left ventricular outflow tract obstruction presenting with a pronounced systolic anterior motion of the anterior mitral valve leaflet was made by echocardiography. This diagnosis was confirmed by cardiac catheterization and angiocardiography. Pathologic findings were consistent with Pompe's disease (type II glycogen storage disease). The presence of systolic anterior motion of the mitral valve in this patient suggests that this finding is not pathognomonic of idiopathic hypertrophic subaortic stenosis.

Angiocardiography↗
PubMed1975

Measurement of cardiac output by thermal dilution in infants and children.

The accuracy of the thermal dilution technique for measuring cardiac output in infants and children has been assessed by comparison with the direct Fick technique. Satisfactory correlation between the two methods has been demonstrated, and it is concluded that a commercially available monitor can be used to determine cardiac output by thermal dilution in acutely sick infants and children. The volume of injectate should be selected according to the weight of the child, and the value displayed by the monitor should be adjusted by the appropriate fraction.

Acute Disease↗
PubMedDate not supplied

The haggis tolerance test in Scots and Sassenachs.

To find out if the Scottish national dish, haggis, contributes to the high incidence of coronary heart disease in Scotland the lipaemic effect of a meal of 200 g of haggis was measured in six Scottish and 10 Sassenach men. The Scots had higher fasting cholesterol and triglyceride concentrations and a lower proportion of high density lipoprotein cholesterol than the Sassenachs. Four subjects were found to have hyperlipoproteinaemia, which had been unrecognised previously. Serum cholesterol concentrations did not change after haggis was eaten (mean dose 2.6 g/kg body weight). Serum concentrations of triglycerides increased by 51% at 90 minutes in the Sassenachs but were unaltered in the Scots. There were no serious adverse effects. This study shows that Scots have higher lipid concentrations than Sassenachs but seem to be resistant to the lipaemic effect of haggis. The haggis tolerance test may be useful in Sassenachs.

Adult↗
PubMedDate not supplied

A polymorphism in the human apolipoprotein AI promoter region: a study in hypertriglyceridaemic patients.

We examined the impact of a G-->A mutation at position -75 of the apolipoprotein AI gene promoter in subjects with hypertriglyceridaemia from two racial groups, Caucasians (n = 52) and Japanese (n = 19) compared to their controls (n = 56 and n = 21 respectively). The mutation was genotyped by the polymerase chain reaction and subsequent digestion using HpaII, and BstNI. We found no significant differences in allele frequency in either control-control or case-control comparisons in European and Japanese populations. Linkage disequilibrium was observed between the mutation and the common alleles of two restriction fragment length polymorphisms, MspI and SstI located in the APOA1 and APOC3 genes, respectively, in the Japanese population. On the basis of these results, the G-75-->A mutation is unlikely to be aetiological in predisposing to hypertriglyceridaemia.

Alleles↗